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Large scale containment

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Pathogen Classes (NIH)<br />

Risk<br />

Group<br />

RG I<br />

RG II<br />

RG III<br />

RG IV<br />

Definition<br />

Agents not associated with disease in<br />

healthy adult<br />

Agents associated with human disease,<br />

rarely serious; preventive or therapeutic<br />

intervention is available<br />

Agents associated with serious or lethal<br />

disease; preventive or therapeutic<br />

intervention may be available; high<br />

individual risk, low community risk<br />

Agents that are likely to cause serious or<br />

lethal disease; preventive or therapeutic<br />

intervention usually not available; high<br />

individual risk, high community risk<br />

Examples<br />

E. Coli K12,<br />

Asporogenic B.<br />

subtilis,<br />

AAV type 1-4<br />

B. Pertussis<br />

H. Influenzae<br />

Dengue, YF 17D ,<br />

Rabies, Hep AE<br />

Y. Pestis<br />

Brucella, JE, YF WT<br />

HIV, HTLV<br />

No bacteria<br />

Ebola, Marburg,<br />

Lassa, H. simiae

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