Development of a New Tool for Modelling Potential Risks from Food ...

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Application of the Tool to Food Contact Materials • Chemicals detected in water stored in polypropylene bottles (Skjevrak et al. 2005) • Chemicals identified and concentrations measured – 72 hr duration ambient temperatures – Highest values from multiple bottles reported in paper 14
Residue Data Compound Concentration in Water ug/l Di isobutyl phthalate 36 Dibutyl phthalate 9 Ethyl-4-Ethoxybenzoate 101 2,4-di-tert-butylphenol 25 Ethylbenzoate 15 4-Methylbenzaldehyde 37 Toxicity Data Compound Cramer Class Safe Level of Intake Reference Di isobutyl phthalate 1 Dibutyl phthalate 1 1 EPA IRIS 1990 Ethyl-4-Ethoxybenzoate 2 2,4-di-tert-butylphenol 1 Ethylbenzoate 1 4-Methylbenzaldehyde 1 15
Page 1 and 2: Development of a New Tool for Model
Page 3 and 4: Challenges Posed by Mixtures • Co
Page 5 and 6: Limitations to the Tool • Does no
Page 7 and 8: Models for Mixture Toxicity (Cont.)
Page 9 and 10: The Cramer Class Approach Class II
Page 11 and 12: Why Perform a Probabilistic Analysi
Page 13: Probabilistic Additive Model of Mix
Page 17 and 18: Results 0.05 Safe Dose mg/kg/d 0.04
Page 19 and 20: Estimates of Safe Doses in Bottled
Page 21: Questions 21

Development of a New Tool for Modelling Potential Risks from Food ...

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