Development of a New Tool for Modelling Potential Risks from Food ...
Development of a New Tool for Modelling Potential Risks from Food ...
Development of a New Tool for Modelling Potential Risks from Food ...
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Limitations to the <strong>Tool</strong><br />
• Does not address carcinogenic / genotoxic effects<br />
– A separate assessment <strong>of</strong> carcinogenic effects is required<br />
• The approach requires in<strong>for</strong>mation on the structure <strong>of</strong> the compounds<br />
– To assign the compounds to a Cramer class<br />
– To confirm that the Munro et al. 1996 data set has similar compounds<br />
– To determine that there are no structural alerts <strong>for</strong> carcinogenicity and<br />
that they are not organophosphorous compounds<br />
• Synergy / Potentiation<br />
– Not modeled directly<br />
– Proposed approach minimizes the potential <strong>for</strong> synergistic effects by<br />
restricting exposures to mixture components to levels where synergy is<br />
unlikely to occur (Konemann and Pieters, 1996)<br />
5
Change language