Development of a New Tool for Modelling Potential Risks from Food ...

Challenges Posed by Mixtures
• Complexity:
– Infinite number of mixtures (can’t test them all)
• Little or no toxicity data for many components of mixtures.
• Traditional approaches for assessing mixture toxicity
– Additive models too conservative (not all effects add);
– Independence models not sufficiently conservative (some might
add);
– Both approaches require toxicity data on all components
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