Development of a New Tool for Modelling Potential Risks from Food ...

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Models for Mixture Toxicity Derived No Effect Level (DNEL) for single compound: DNEL = POD AF A AF H POD = Point of departure (NOAEL, NOEL, LOAEL, BMD, etc.) AF = Adjustment Factor (interspecies or interindividual uncertainty) DNEL for mixture assuming additivity: Mixture DNEL = -1 -1 POD Σ F i i AF Ai AF Hi F i = Weight fraction of the i th chemical in the mixture 6
Models for Mixture Toxicity (Cont.) DNEL for mixture assuming independence: Mixture DNEL = Min POD i AF Ai AF Hi F i Contributions to Additive models of mixture toxicity can be ranked based on: Toxicity Weight of Compound = F i AF Ai AF Hi POD i Mixture components with the highest weights will drive the mixture’s toxicity and can be investigated further. 7
Page 1 and 2: Development of a New Tool for Model
Page 3 and 4: Challenges Posed by Mixtures • Co
Page 5: Limitations to the Tool • Does no
Page 9 and 10: The Cramer Class Approach Class II
Page 11 and 12: Why Perform a Probabilistic Analysi
Page 13 and 14: Probabilistic Additive Model of Mix
Page 15 and 16: Residue Data Compound Concentration
Page 17 and 18: Results 0.05 Safe Dose mg/kg/d 0.04
Page 19 and 20: Estimates of Safe Doses in Bottled
Page 21: Questions 21

Development of a New Tool for Modelling Potential Risks from Food ...

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