Development of a New Tool for Modelling Potential Risks from Food ...

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Using the Munro et al. Analysis of Cramer Classes to Fill Data Gaps • Cramer 1 classes associate structural properties with toxicological potency • Assignment to the three Cramer classes is made based on structure • Use the lower 5 th percentile of the distribution or NOELs as the POD • Use 100 fold adjustment factor proposed by Munro et al. 1996 2 . 1 Cramer et al. 1978 Food Cosmetic Toxicology Vol. 16. pp.255-278 2 Munroe et al. 1996 Food and Chemical Toxicology Vol 34. pp 829-867 8
The Cramer Class Approach Class II Class I 5%ile NOEL (mg/kg/day) 3.0 Class III Class I II 0.91 III 0.15 9
Page 1 and 2: Development of a New Tool for Model
Page 3 and 4: Challenges Posed by Mixtures • Co
Page 5 and 6: Limitations to the Tool • Does no
Page 7: Models for Mixture Toxicity (Cont.)
Page 11 and 12: Why Perform a Probabilistic Analysi
Page 13 and 14: Probabilistic Additive Model of Mix
Page 15 and 16: Residue Data Compound Concentration
Page 17 and 18: Results 0.05 Safe Dose mg/kg/d 0.04
Page 19 and 20: Estimates of Safe Doses in Bottled
Page 21: Questions 21

Development of a New Tool for Modelling Potential Risks from Food ...

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