Development of a New Tool for Modelling Potential Risks from Food ...
Development of a New Tool for Modelling Potential Risks from Food ...
Development of a New Tool for Modelling Potential Risks from Food ...
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Models <strong>for</strong> Mixture Toxicity (Cont.)<br />
DNEL <strong>for</strong> mixture assuming independence:<br />
Mixture DNEL =<br />
Min<br />
POD i<br />
AF Ai AF Hi<br />
F i<br />
Contributions to Additive models <strong>of</strong> mixture toxicity can be<br />
ranked based on:<br />
Toxicity<br />
Weight <strong>of</strong><br />
Compound<br />
=<br />
F i<br />
AF Ai AF Hi<br />
POD i<br />
Mixture components with the highest weights will drive the<br />
mixture’s toxicity and can be investigated further.<br />
7
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