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Mechanisms of yogic practices in health, aging, and<br />

dise<strong>as</strong>e. Mt Sinai J Med. 2010 Sep-Oct;77(5):559-69.<br />

By Kuntsevich V, Bushell WC, Theise ND. From Beth<br />

Israel Medical Center of Albert Einstein College of<br />

Medicine, New York, NY 10003, USA.<br />

vkuntsev@chpnet.org<br />

Abstract: Mechanisms underlying <strong>the</strong><br />

modulating effects of yogic cognitive-behavioral<br />

practices (eg, meditation, yoga <strong>as</strong>an<strong>as</strong>, pranayama<br />

breathing, caloric restriction) on human physiology can<br />

be cl<strong>as</strong>sified in<strong>to</strong> 4 transduction pathways: humoral<br />

fac<strong>to</strong>rs, nervous system activity, cell trafficking, and<br />

bioelectromagnetism. Here we give examples of <strong>the</strong>se<br />

transduction pathways and how, through <strong>the</strong>m, yogic<br />

practices might optimize health, delay aging, and<br />

ameliorate chronic illness and stress from disability.<br />

We also recognize that most studies of <strong>the</strong>se<br />

mechanisms remain embedded in a reductionist<br />

paradigm, investigating small numbers of elements of<br />

only 1 or 2 pathways. Moreover, often, subjects are not<br />

long-term practitioners, but recently trained. The<br />

models generated from such data are, in turn, often<br />

limited, <strong>to</strong>p-down, without <strong>the</strong> explana<strong>to</strong>ry power <strong>to</strong><br />

describe beneficial effects of long-term practice or <strong>to</strong><br />

provide foundations for comparing one practice <strong>to</strong><br />

ano<strong>the</strong>r. More flexible and useful models require a<br />

systems-biology approach <strong>to</strong> ga<strong>the</strong>ring and analysis of<br />

data. Such a paradigm is needed <strong>to</strong> fully appreciate <strong>the</strong><br />

deeper mechanisms underlying <strong>the</strong> ability of yogic<br />

practice <strong>to</strong> optimize health, delay aging, and speed<br />

efficient recovery from injury or dise<strong>as</strong>e. In this regard,<br />

3 different, not necessarily competing, hypo<strong>the</strong>ses are<br />

presented <strong>to</strong> guide design of future investigations,<br />

namely, that yogic practices may: (1) promote<br />

res<strong>to</strong>ration of physiologic setpoints <strong>to</strong> normal after<br />

derangements secondary <strong>to</strong> dise<strong>as</strong>e or injury, (2)<br />

promote homeostatic negative feedback loops over<br />

nonhomeostatic positive feedback loops in molecular<br />

and cellular interactions, and (3) quench abnormal<br />

"noise" in cellular and molecular signaling networks<br />

arising from environmental or internal stresses.<br />

<br />

<br />

A Critical Review of <strong>the</strong> Effects of Medical Qigong<br />

on Quality of Life, Immune Function, and Survival<br />

in Cancer Patients. Integr Cancer Ther. 2011 Jun 28.<br />

by Oh B, Bu<strong>to</strong>w P, Mullan B, Hale A, Lee MS, Guo X,<br />

Clarke S. from University of Sydney, Sydney, New<br />

South Wales, Australia.<br />

Background. Due <strong>to</strong> <strong>the</strong> limitations and side<br />

effects of conventional cancer treatment, especially in<br />

relation <strong>to</strong> quality of life (QOL), patients are<br />

incre<strong>as</strong>ingly utilizing complementary and alternative<br />

medicine (CAM) <strong>to</strong> supplement health-related<br />

outcomes. However, evidence for <strong>the</strong> safety and<br />

efficacy of such treatments is lacking.The purpose of <strong>the</strong><br />

current review w<strong>as</strong> <strong>to</strong> investigate evidence for <strong>the</strong> role<br />

of one CAM, medical Qigong (MQ), in supportive care.<br />

METHODS: The literature w<strong>as</strong> searched for reported<br />

effects of MQ in improving QOL, immune function, and<br />

survival in cancer patients. RESULTS: Although many<br />

studies possessed methodological limitations and small<br />

sample sizes, encouraging evidence w<strong>as</strong> found for <strong>the</strong><br />

effects of MQ on <strong>the</strong>se health-related outcomes. More<br />

robust evidence in <strong>the</strong> form of randomized controlled<br />

trials with larger sample sizes also reflected positive<br />

results for <strong>the</strong> role of MQ in improving QOL, mood and<br />

fatigue parameters, and reducing inflammation.<br />

CONCLUSION: Given such encouraging results,<br />

fur<strong>the</strong>r research is recommended in methodologically<br />

sound approaches <strong>to</strong> fur<strong>the</strong>r delineate <strong>the</strong> action of MQ.<br />

These findings support <strong>the</strong> utilization of MQ by cancer<br />

patients and <strong>the</strong> place for such programs in<br />

comprehensive cancer care.<br />

<br />

<br />

<strong>September</strong>, 2011 <strong>Yang</strong>-<strong>Sheng</strong> (Nurturing Life) 21

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