Protein-Protein Interactions, Networks and Pathways - Chagall

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Domain-Domain <strong>Interactions</strong>• Many PPI predictions are based on identifyinginteracting domain pairs or domain-motifs. (Ref:Deng et al.,2002, Ng et al.,2003, Riley et al., 2005, Sprinzak et al.,2001,Li et al., 2004, Neduva et al., 2005, Wang et al.,2004, Betel et al.,2007)• Based on identifying over representeddomain pairs in interacting proteins orconserved motifs.• To date, only a small number of conservedrecognition motifs have been identified(Scansite, ELM).
Domains <strong>and</strong> protein interactionsPawson T., Nash P., (2003), Science, 300,445-452
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Protein-Protein Interactions,Networ
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Protein Interactions• A geometric
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Yeast-two-hybrid• Widely used for
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Page 68 and 69: Learning the motifsRhoGAPPPI source
Page 70 and 71: Converting a motif to a profile
Page 73: Verified PredictionsBetel D. et al.
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Protein-Protein Interactions, Networks and Pathways - Chagall

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