Read-Across, Grouping and Categories: possibilities and ... - Europa

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Groups and Categories (5)• Read-across from one source to many targets hasthe undesirable effect that it multipliesuncertainty over many hazard assessments.• It is better to test a number of additional sources,so as to come to a better prediction of thehazards.29/02/2012 12
Read-across (1)• Read-across introduces extra uncertainty!• The data requirement is normally met by means of anexperimental study (for instance an oral 90-day studywith rats).• Extra uncertainty introduced by read-across:translation from an experimental study with a similarsubstance to the experimental study with theregistered substance.• REACH guidance: this uncertainty is to be addressedby means of extra uncertainty factor (AF) during DNELderivation; at least 2.29/02/2012 13
Page 11: Groups and Categories (4)• Read-a
Page 15 and 16: Possible supporting data• Depends
Page 17 and 18: Part of the Legal Text:• Adequate
Page 19 and 20: Core of every RA explanation• Wha
Page 21 and 22: Possible Read-Across “Explanation
Page 23 and 24: Identity of substances• The valid
Page 27: Thank YouKarel de Raatecha.europa.e

Read-Across, Grouping and Categories: possibilities and ... - Europa

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