Read-Across, Grouping and Categories: possibilities and ... - Europa

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Read-across (2)• Read-across means that properties are predicted andnot directly measured.• The registrant has to explain why this is possible;not ECHA.• So the core of every read-across proposal, whetherbased on groups or on categories, should be such anexplanation (a.k.a. read-across hypothesis).• Often, this explanation needs to be supported withexperimental data.• No sufficient explanation, no acceptance!29/02/2012 14
Possible supporting data• Depends obviously on the explanation.• Data on the absorption, distribution, metabolism,excretion and elimination of source and/or target;toxicokinetics or ADME.• In vitro data that are related to the effect for whichread-across is proposed.• In silico investigations.• Data for other REACH-relevant properties.Any scientific evidence that really enhancesthe credibility of the read-across explanation29/02/2012 15
Page 11 and 12: Groups and Categories (4)• Read-a
Page 13: Read-across (1)• Read-across intr
Page 17 and 18: Part of the Legal Text:• Adequate
Page 19 and 20: Core of every RA explanation• Wha
Page 21 and 22: Possible Read-Across “Explanation
Page 23 and 24: Identity of substances• The valid
Page 27: Thank YouKarel de Raatecha.europa.e

Read-Across, Grouping and Categories: possibilities and ... - Europa

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