Read-Across, Grouping and Categories: possibilities and ... - Europa

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Worst-case approach• Depending on the role of the outcome of read-acrossin hazard assessment, a worst-case approach can befollowed.• In some cases, it is possible to argue that the sourcewill anyhow be more toxic than the target.• An underestimation of a hazard is then prevented.• Is the overestimation acceptable?• What if the read-across is not conservative enoughand there is an underestimation of a hazard?29/02/2012 22
Identity of substances• The validity of read-across may be affected by thecomposition of, and impurities in the source and/ortarget;• In particular, if impurities in the target contribute tothe toxicity while they are not present in the source.29/02/2012 23
Page 11 and 12: Groups and Categories (4)• Read-a
Page 13 and 14: Read-across (1)• Read-across intr
Page 15 and 16: Possible supporting data• Depends
Page 17 and 18: Part of the Legal Text:• Adequate
Page 19 and 20: Core of every RA explanation• Wha
Page 21: Possible Read-Across “Explanation
Page 27: Thank YouKarel de Raatecha.europa.e

Read-Across, Grouping and Categories: possibilities and ... - Europa

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