Using Lomb-Scargle Periodograms to Identify Periodic Genes in ...

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Mary-Lee’s Somitogenesis DatasetWe wanted to validate the Lomb-Scargle method withBozdech’s dataset before applying to our somitogenesisproblem, since the Fourier technique could not be used:Scargle (1982):“surprising result is that the … spectrum of a process canbe estimated … [with] only the order of the samples …”32
Somitogenesis DatasetCosine (N = 10 )Time Interval VariabilityCosine Curve-1.0 0.0 0.5 1.0Frequency0 2 4 6 8N100.1p0 20 40 60 80 100Time [minutes]-6 -4 -2 0 2 4 6log10(delta T)170.006Normalized Power Spectral Density0 2 4 6 8 10Lomb-Scargle Periodogramperiod = 119 minutes0.005 0.015 0.025Probability0.0 0.4 0.8p = 0.1058Peak Significance0.005 0.015 0.02520480.0023E-9Frequency [1/minute]Frequency [1/minute]33
Page 1 and 2: Using Lomb-Scargle Periodogramsto I
Page 3: Periodic Patterns in BiologyA verte
Page 6 and 7: What is a Periodogram?• A graph s
Page 8 and 9: Lomb-Scargle PeriodogramExample Usi
Page 10 and 11: Lomb-Scargle PeriodogramExample Usi
Page 12 and 13: Lomb-Scargle Periodogram Experiment
Page 14 and 15: Lomb-Scargle Periodogram Experiment
Page 16 and 17: Lomb-Scargle Experiment:Mixtures: P
Page 18 and 19: Data Pipeline to Apply to Microarra
Page 20 and 21: Bozdech’s Plasmodium dataset:1. A
Page 30 and 31: Bozdech’s Plasmodium dataset:Boze
Page 34 and 35: Somitogenesis DatasetMary-Lee, Scie
Page 36 and 37: Somitogenesis DatasetDo we care abo
Page 38 and 39: Somitogenesis DatasetPerturbation (
Page 44 and 45: Somitogenesis DatasetWhat periodici
Page 46 and 47: Conclusions• Lomb-Scargle periodo
Page 48: AcknowledgementsPourquie LabOlivier

Using Lomb-Scargle Periodograms to Identify Periodic Genes in ...

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