FINAL PROGRAM 6TH EDITION - EuroMediCom

A SPLIT-FACE COMPARISON OF TWO HYALURONIC ACID FACIAL FILLERS IN THE TREATMENT OF NASO-LABIAL FOLDSPHILLIP LEVY 1 , HERVÉ RASPALDO 2 , KOENRAAD DE BOULLE 3Background: The ageing process, combined with volume loss and muscular hyperactivity, leads to the formation of folds and wrinklesin the face. Dermal fillers are commonly used to treat these and improve facial volume. Juvéderm? ULTRA 3 is a new addition to theaesthetic armamentarium of facial fillers. It is a smooth cohesive hyaluronic acid gel for injection into the medium/ deep dermis. It alsocontains 0.3% lidocaine, which has been shown to significantly reduce the pain of injection.1The objective of this study was to compare the injection comfort and ease of injection of Juvéderm ULTRA 3 with Restylane - Perlane?in a split- face, single-blind design.Method : One hundred and twenty six subjects were enrolled at three centres: one each in France, Belgium and Switzerland. Eachsubject received both products, which were randomly assigned to the right or left naso-labial fold. Subjects were blinded as to whichside was injected with each product.Using the British Pain Scale the level of injection pain and ease of injection was assessed by the injectors, while the patients assessedthe level of injection pain and stated if they had a preference for one treatment over another and if so, why.Results: The mean age of subjects was 52.9 years and 97% were female. The mean injection volume was 0.6ml for both products.When assessed by both injector and subject, pain of injection, pain of massaging the injected area and post-injection discomfort werestatistically significantly less on the side treated with Juvéderm ULTRA 3 ( p< 0.0001, for all parameters). 92% of the injections withJuvéderm ULTRA 3 were considered 'very easy' by the injectors and 8% were considered 'fairly easy'. This compared with 21% 'veryeasy' and 34% ' fairly easy' with Restylane - Perlane?. When asked which injection experience they preferred overall, 95% of subjectspreferred Juvéderm ULTRA 3.Adverse events were mild and transient with both products.Conclusions: Juvéderm ULTRA 3 provides superior comfort during injection, massaging and in the post- injection period comparedwith Restylane - Perlane? when assessed by both injectors and patients. Patients were able to feel the difference between the twoinjection experiences and commented that both products gave a good aesthetic result but that the Juvéderm ULTRA 3 injection wasa far more comfortable and gentle experienceReferences:1. Comparison of Injection Comfort and Ease with Juvéderm ULTRA 3 and Surgiderm 30 XP Poster presented at IMCAS, Paris, January 9-12 20081 Private Practice, Genèva; 2 Specialist Consultant in Facial Plastic Surgery, University of Nice; 3 Aalst Dermatology Group, Aalst, BelgiumTHE JUVÉDERM ULTRA EUROPEAN EXPERT EVALUATIONGREGOR WAHL 1 AND THE JUVÉDERM ULTRA 3 EXPERT GROUPBackground: The Juvéderm ® ULTRA range is a new category of hyaluronic acid filler, containing 0.3% lidocaine for improved patientcomfort both during and after injection. Juvéderm® ULTRA 3 is a smooth cohesive gel, indicated for injection into the mid / deepdermis. This evaluation was designed to assess injector and patient opinions of the comfort and aesthetic result of Juvéderm ® ULTRA3 in the naso-labial foldsPOSTERS__________________Method: 82 injectors from France, Italy, Spain, Germany and the UK were recruited and injected 806 patients with Juvéderm ® ULTRA3. All of these patients had received a filler in the naso-labial fold area within the previous 18 months and had returned to their aestheticpractitioner requesting another treatment.Both injectors and patients assessed the level of pain felt [British Pain Scale (0= no pain and 10 = worst pain imaginable)] during andafter the procedure and the aesthetic result achieved. Additionally injectors assessed the ease of the injection and reported whetherthey would recommend Juvéderm ® ULTRA 3 to professional colleagues and other patients seeking treatment with dermal filler. Patientswere also asked if they would recommend the treatment and how it compared with their previous experience with other dermal fillersResults: 806 patients were injected, 92% were female. Previous fillers included Restylane, Hydrafill and Surgiderm. Both injectors andpatients reported low levels of pain during the injection procedure, massaging or sculpting and 5-10 minutes after the injection. 86.9%of patients considered that the overall injection experience with Juvéderm ® ULTRA 3 was 'significantly' or 'somewhat' more comfortablethan with their previous filler injection.With regard to the aesthetic result, 94.9 % of the injectors and 95.7% of the patients considered the result 'excellent' or 'good'. Almost2/3 of injectors (64.1%) rated the aesthetic result as better than previous fillers. Both groups would recommend Juvéderm ULTRA 3 toothers. When asked about the ease of injection 98% of injectors found Juvéderm ® ULTRA 3 easy to inject and sculpt.Conclusion: Juvéderm ® ULTRA 3 with 0.3% lidocaine provides a more comfortable injection experience and improved aesthetic resultfor the patient compared with previous experience of dermal fillers.1 Private Practice, Berlin, Germanys138