FINAL PROGRAM 6TH EDITION - EuroMediCom

structure and wrinkles (anti-aging-effect).On the other side, the photoaging process of the human skin in the presence of natural sunlight or artificial UV-sources happenscontinuously and leads in time to dryness, deep wrinkles, sagging, lost of elasticity, mottled pigmentation and skin telangiectasia.Typical biomarkers include a strong generation of free radicals, lipid peroxidation, collagenase activation, glycation / oxidation ofproteins (AGE products), activation of p53 transcription factors, low DNA repair capacity and cumulative DNA mutations.Clinically, the adverse effects of natural sunlight and other UV-sources on normal human skin may vary from sunburn with erythema,oedema and DNA damage (12-24 hrs. after UV-exposure) to polymorphic light reaction (eczema solare), solar actinic elastosis andactinic hyperkeratosis (as common precancerous condition), up to different skin cancer forms like basal cell carcinoma (BCC),squamous cell carcinoma (SCC) or malignant melanoma (MM).The study of the lipid, protein and DNA oxidative damage triggered by the free radical attack subsequent to sunlight exposure hasconducted to appropriate strategies to slow down or block these reactions making possible the design of innovative skin careformulations.In this respect, a new German photoaging defence formula (SOLARIS ® ) combines for the first time the double UVA + UVB protection(SPF 25) with melanin promoting aminoacids directly enhancing the natural tanning process. Free radical blocking agents like Vit. Eand carrot oil, are preventing the sun exposure side-effects together with immune stimulating plant extracts ( -glucans) with antiherpesvirus activity.To slow down the photoaging related wrinkle formation efficiently, a new collagen synthase stimulating formula (ENERGO RepairComplex ® ) offers a synergistic anti-aging combination of UV-light blockers, free radical quenchers (Vit. E, Coenzyme Q10) andcollagen/ elastin synthesis promoters like hydroxyprolin and plant bioflavonoids. The active ingredients are incorporated in liposomescontaining skin identical phospholipids and ceramides by means of the patented DMS ® nanoparticle technology. A rapid uptake in theepidermis cells is thus granted.The use of the described hypoallergenic topical products results in a significant improvement of the skin structure and appearancewithin 30 days, as documented with the standardized Surface Evaluation of Living Skin (SELS) methodology in a group of 35 womenaged 40 to 63 years.Goals & Objectives- Understanding the role of cellular energetics in chronic inflammatory skin diseases (psoriasis, acne, eczema) and aging- Explaining the biomarkers of the skin aging process as background for specific anti-aging treatments- Describing innovative procedures and formulas to counteract the described chronic dermatoses and wrinkle formation- Monitoring the anti-aging therapy results by means of the standardized Surface Evaluation of Living Skin (SELS) methodologySESSION 11AAJAPAN ANTI-AGING MEDICINELA MEDECINE ANTI-AGE AU JAPONCHAIR: YOSHIKAZU YONEI PROFESSOR OF GASTROENTEROLOGY (KYOTO, JAPAN)9.30 am / 9h30ANTI-AGING SECRETS OF JAPANESE CENTENARIANS AND ELDERLY PEOPLELE SECRET ANTI-ÂGE DES CENTENAIRES JAPONAISTAKUJI SHIRASAWA(JAPAN)ANTI-AGING MEDICINEThe life expectancies of Japanese male and female are 78.32 and 85.23 years in 2003, respectively, which showed that Japanrepresents one of the most remarkable countries for the logevity over the world.The life expectancies in Japan dramatically extended during last 100 years, by 30 years from around 50 years to over 80 years.Molecular analyses of the model system such as C. elegans or Drosophila melanogaster suggested that there are several dozens ofgenes that regulate the lifespan of animals. Some germline mutations in such model organisms etend the lifespan of model organismsas long as 2-6 times. Moreover, molecular analyses of human premature aging syndromes such as Werner syndrome or Hutchinson-Gilford syndrome suggest that genes encoding DNA repair enzymes are responsible for the development of ageing phynotypes inhuman. In addition to the genetic factors, environmental factors such as diet and physical exercises as well as the wellness of mentalstate also play an important role in the determination of lifespan in individuals.Japanese centenarian studies suggest that independency, daily diet, daily physical exercises,and the motivation for life, and thepositive way of thinking are the pivotal factors influencing the QOL of Japanese centenarians.The frailty of elderly people becomesone of the important social issues in Japan, which would be further improved by the alterations of lifestyles such as dietary interventionor physical exercises. I will present the secrets of longevity from Japanese centenarian studies in the lecture.GLOBAL NETWORK OF ANTI-AGING ACTIVITIY FROM JAPANLE RÉSEAU GLOBAL ANTI-ÂGE AU JAPONYOSHIKAZU YONEI(JAPAN)Anti-Aging Medical Research Center, Doshisha University has a global project on which it works in cooperation with Japanese Societyof Anti-Aging Medicine. It is to publish an international medical journal, to promote the network software using an Anti-Aging QOLCommon Questionnaire, and finally to establish the common data bases. The piling of medical evidence is basic for the developmentof anti-aging medicine.The journal "Anti-Aging Medicine" (ISSN 1882-2762) that valued the transparency and neutrality was published for this end. Originalarticles are in English, with the advantage of the internet, also translation forms of Japanese or other language are postedsimultaneously (http://www.anti-aging.gr.jp/webjournal/index.html). The policy of this journal avoids choosing only convenient data, andnegative data or data with controversy are also welcomed. The valuable information is often included in these raw data."Aging Check" is network software that supports facilities in which it engages it in the anti-aging medicine. It collates with Japanese102