combination of coordination or ionic bonds.Virtually all biochemicals exhibit the ability to dissolve metal cations. Thus proteins, polysaccharides, and polynucleic acids areexcellent polydentate ligands for many of the metal ions.Chelation therapy describes the use of chelating agents to detoxify poisonous metal agents such as mercury, arsenic, and lead byconverting them to a chemically inert form that can be excreted without further interaction with the body. Very often, there is confusionbetween detoxification and chelation. Detoxification should be used to describe techniques used to help the body eliminate a toxic.Testing of homocystein, antioxidant (selenium, vitamine C and B, SOD, glutathion peroxydase), and magnesium is absolutelynecessary before practicing any chelation.The use of chelation in case of acute metal intoxication or high chronic metal intoxication is medically well understood and accepted.In case of slight environmental intoxication the problem is different; the presence of mercury in the hair of in the urine is not the proofof a metal intoxication. As many chelating treatments have proven or potential side effects, especially because there are not specificof a metal, it is important to prove the intoxication. The Melisa test ® is actually the best biological test for metal intoxication.It is also important to follow the metal intoxication through a Melisa ® test or urine dosage before and after chelation. If the metal intakeis stopped the intoxication will disappear spontaneously in a few months. If it is not possible to stop the metal intake the chelationshould theoretically be continued over a long period but the innocuousness of such a treatment has not be proven.Oral chelation is only efficient on the intestine content.The chelator ties to metals present in the intestine. As it is not a specific reaction it can tie to any metals from magnesium or calciumto mercury. If the heavy metal is regularly absorbed as it is the case for teeth fillings or if the food is polluted with toxic metals this kindof chelation could be prescribed. This kind of chelation may also interfere with the reabsorption of toxic metals eliminated through theliver into the bile.Oral DMSA speeds the elimination of mercury, lead, and arsenic, antimony, bismuth, and gold it is considered as the safest and mostscientifically studied.Chlorella is a genus of single-celled green algae. In vitro Chlorella is capable of absorbing a great quantity of metals. It has proven itsefficiency when absorbed with the metal in mice. The few data we have from case reports demonstrate that the increase of metalexcretion is only in feces and not in urine. This should stop all the literature about the action of chlorella in side the vessels or theneurological system. There are no serious medical studies proving efficacy in case of intoxication in human beings. This is verysurprising because the claims for mobilization of mercury from tissues or facilitation of mercury excretion are not scientifically proven.Cilantro, a particular form of coriander, is in the same scientific situation as chlorella.D-penicillamine is used in Wilson's disease to chelate copper.Other molecules like glutathione and lipoic acid have shown a slight in vitro chelation capacity. Their efficacy is probably more tied toa positive reinforcement of the body's detoxification capacity than a chelating effect. Many so called "chelating food complements" arein this situationIV chelation is usually practiced with EDTAEDTA is the abbreviation for ethylenediaminetetraacetic acid. This amino acid is widely used to sequester di- and trivalent metal ions.EDTA binds to metals via four carboxylate and two amine groups. EDTA forms especially strong complexes with Mn, Pb Cu, Fe, andCo. It also ties to Calcium, magnesium and many heavy metals. It has very few effects on mercury intoxication. Doctor Wittel anAmerican MD practicing a lot of EDTA chelation in the USA estimates that approximately 500 000 American take this treatment everyyear. The main use seems to be for arteriosclerosis with the aim to take away the calcium from the arteries. It is also used in manyother indication such metabolic disturbances (cholesterol excess, diabetes), bone and muscle pain, antiaging (skin, Alzheimer, hair,eyes) and chronic fatigue syndrome. The positive impact on cardiovascular disease has not been scientifically proven in any doubleblind test but a very big trials is being conducted at the moment to prove or infirm the benefit for post cardiac infarctus patient(http://nccam.nih.gov/chelation). The positive impact on lead intoxication is not to be discussed. But we are lacking studies on humansfor other heavy metals intoxication. It is always associated with minerals and vitamins supplementation because of its chelating effects.ANTI-AGING MEDICINEDMPS is potentially too toxic to use and no longer has place in the practice of medicine. Some continue to use it for acute mercuryintoxication, but it may not be safe.Déféroxamine is used for iron or aluminium acute intoxicationConclusion: Chelation seems to be therapeutically interesting. A number of case reports are in favor of this kind of treatment. We needmore scientific experimentation on humans to validate the technique and have a better estimation of the risks. It should never beisolated from estimation and treatment of the body capacity of desintoxication.Chelators as antidotes of metal toxicity: therapeutic and experimental aspects. Blanusa M, Varnai VM, Piasek M, Kostial K. Curr MedChem. 2005;12(23):2771-94.Cilantro, Chlorella and Heavy metals. John Millet Medical Herbalism Vol 14 n°4:17-20Treatment of Mercury and Lead Poisonings with Dimercaptosuccinic Acid (DMSA) and Sodium Dimercaptopropanesulfonate (DMPS)Jan Aaseth, Dag Jacobsen, Ole Andersen, Elsa WickstrØm Analyst 1995 Mar; Vol 120, page 853ff91
Friday April 11 / Vendredi 11 AvrilANTI-AGING MEDICINEROOM / SALLE MAILLOTSESSION 5AASEXOLOGY AND SEXUAL ENDOCRINOLOGY: OXYTOCIN, THE SEXIEST HORMONE EVER? RELAXIN, THE FORGOTTEN HORMONE?SEXOLOGIE ET ENDOCRINOLOGIE SEXUELLE : OCYTOCINE, LA PLUS ATTIRANTE DES HORMONES ? RELAXINE, L'HORMONE OUBLIÉE ?CHAIR: RONALD VIRAG VASCULAR SURGEON, SEXOLOGIST (PARIS, FRANCE)GORM WAGNER ANTI-AGING MEDICAL DOCTOR (COPENHAGEN, DENMARK)8.30 am / 8h00OXYTOCIN CAN PROVIDE WOMEN WITH MULTIPLE ORGASML'OCYTOCINE PEUT DONNER AUX FEMMES DE MULTIPLES ORGASMESJORGE FLECHAS(USA)OXYTOCIN FOR MEN TOO?L'OCYTOCINE AUSSI POUR LES HOMMES ?CLAUDE DALLE(FRANCE)Oxytocin (OT) in not only a female hormone ; men have it and it acts like a neurotransmitter in the brain, but like an hormone in theblood.In the brain, it activates the liberation of acetylcholine, dopamine and noradrenaline alphareceptors.It can be counteract by GABA, and noradrenaline betareceptors. We can stimulate the OT by the serotonine, so important for the brainpeace.Oxytocin does not need a feedback, but its half life is very fast, only 5 to 10 mn.It seems nearly like ADH, and works a little bit like it.OT acts on the seminiferous tubules by contracting muscles to push out spermatozoa, and OT participates strongly to the prostatecontraction during orgasm, so is helpful for fertility.Like for women, OT creates attachment between people, particularly during arousal and orgasm.It is certainly one of its main action. Only a physical contact stimulates the OT secretion !During orgasm, we can observe an increase in the level of OT just before the conclusion:The level of OT seems correlated to the orgasm intensity.The penis has many OT receptors. The ventral prostate also.We restore male ejaculation with OT, but, because of its short half life, we need for men to take it during arousal or erection time.But we know now that at low level we can have and increase a penile erection, but at high level, we have inversely a detumescence.OT is decreasing the stress, and cortisol; its also an anxiolytic hormone, a relaxing hormone.By this way it helps to sexual receptivity and counteracts impotence.We will see the dose during the lecture.ANTI-AGING MEDICINEOXYTOCIN AND FIBROMYALGIAOCYTOCINE ET FRIBROMYALGIEJORGE FLECHAS(USA)RELAXIN: ITS ROLE IN THE PATHOGENESIS OF FIBROMYALGIARELAXINE : SON ROLE DANS LA PATHOGÉNÈSE DE LA FIBROMYALGIESAMUEL YUE(USA)POLYHORMONAL AND METABOLIC INFLUENCES IN MALE SEXUAL DYSFUNCTIONINFLUENCES POLYHORMONALES ET MÉTABOLIQUES DANS LA DYSFONCTION SEXUELLE CHEZ L’HOMMERONALD VIRAG - VÉRONIQUE HASTERT(FRANCE)CHANGES IN THE PHYSIOLOGICAL RESPONSES TO SEXUAL STIMULATION DURING LIFESPANCHANGEMENTS DES RÉPONSES PHYSIOLOGIQUES À LA STIMULATION SEXUELLE AU COURS DE LA VIEGORM WAGNER(DENMARK)The basic physiological mechanisms in response to sexual stimulation in both women and men shall be presented.The psychological and somatic changes in sexual response will be discussed in relation to aging.92