FINAL PROGRAM 6TH EDITION - EuroMediCom

STUDY FOR ASSESSMENT OF EFFICACY OF A NON ANIMAL STABILIZED HYALURONIC ACID (RESTYLANE ® ) ONBIOMECHANICAL PROPERTIES OF LIPS. PROSPECTIVE CLINICAL STUDYETUDE DE L'EFFICACITÉ D'UN ACIDE HYALURONIQUE STABILISÉ NON-ANIMAL (RESTYLANE ® ) SUR LES PROPRIÉTÉSBIOMÉCANIQUES DES LÈVRES. ETUDE CLINIQUE PROSPECTIVEELENA GUBANOVA(RUSSIA)Introduction: Injections of HA fillers into the lips is very popular procedure in Russia. For this type of treatment we have patients withwide range of age, because reason of this procedure is not just improvement of form and volume of lips, but also prevention of lipsaging. ?ur clinical experience shows that after lips procedure we have good clinical results for skin of perioral zone indicating adecrease of perioral wrinkles. If there are numerous papers dealing with HA injections into the face skin, but there are no papers aboutHA injections into lips and measurements of the lip functional properties.Objective: To assess the efficacy of non-animal stabilized hyaluronic acid (NASHA, Q-MED) by clinical assessment and by using noninvasivemethods.Subjects: Two groups: the first one included 27 patients (mean age 41,55±13,36 ), which were treated by Restylane, and ControlGroup, 20 persons (mean age 42,65±10,67).Study design: All patients had clinical and instrumental assessment before Restylane (D0), W2 (2 weeks after treatment), M2 (2months after treatment), M4 (4 months after treatment) and 6M (6 months after treatment).Materials and methods: Biomechanical properties were measured by means of Ballistometry (Dia-Stron UK, Ballistometer BLS 780),TEWL by Vapometer (Monaderm, Courage+Khazaka, Germany), hydratation by Corneometer (Monaderm, Courage+Khazaka,Germany) and SkinChip (L'Oreal, Paris) at each visit (D0, W2, M2, M4, M6).Results: Ballistometry data show that Restylane injection makes skin of the lips less viscous (more elastic) after 2, 4 and 6 months incomparison with the baseline and with the Control Group. Results show that hydratation of the lips increases after Restylane injectionsand that the TEWL was more controlled in the treated group.Conclusion: Our pilot study demonstrated that Restylane injection has positive influence on biomechanical parameter of the skin oflips in comparison with the baseline and Control Group. Hydratation parameters exhibit also positive results. The satisfaction levelabout Restylane procedure is maximum after 2 weeks and is maintained for 6 months according to volunteers.AESTHETIC DERMATOLOGY & SURGERYAUTOLOGOUS FIBROBLASTS GRAFTING FOR FACE REJUVENATIONGREFFE DE FIBROBLASTES AUTOLOGUES POUR LE RAJEUNISSEMENT FACIALCHRISTOPH GANSS(GERMANY)EnglishWe report our experience with 141 treatments by 92 patients over 3 yearsIndication: Textural changes of face skin due to ageing. Ideally patient between 40 to 60 without too much skin sagging.Technique: A small skin biopsy is done behind the ear, then the specialised laboratory (Ticeba, Germany) will isolate the fibroblastsand culture them. We inject a first batch of 90 million fibroblasts 3 months after biopsy and another batch of 90 million cells two monthslater. The injection technique is very specific and a particular training is needed.Ideal treatments areas: face, neck and decolleté.Results: a progressive change in the skin texture occur within 2-3 months after treatment and increases for 6 months or more. Skinthickness and skin elasticity are improved with a slight tensing effect on the whole face, thus giving a real rejuvenation effect. If a facelift is indicated this technique is not replacing it.From our collective of 92 patients, 21 asked for a second zone treatment, 25 patients are currently under the treatment procedure.The limiting factor for this treatment is the price which is high due to the sophisticated technology of the laboratory work.FrançaisLe développement des techniques d'isolement et de culture cellulaire a permis une application esthétique des greffes de fibroblastes,déjà utilisées chez les grands brûlés et dans certains cas de plaies chroniques, en association ou non avec des kératinocytes.Ce traitement se fait en trois phases :1. biopsie cutanée, isolement et culture des fibroblastes.2. (J.90) première injection sur l'ensemble du visage de 90 millions de fibroblastes.3. (J.150) seconde injection sur les mêmes zones de 90 millions de fibroblastes.Nous rapportons l'expérience de plus de 57 traitements depuis deux ans réalisés chez 48 patients.Technique : Anesthésie par blocs de la face, EMLA et O2/N2O.Injection très superficielle : à la jonction dermo-épidermiqueEffets secondaires immédiats :- Erythème et œdème pendant les premières 12 h.- Quelques rares hématomes.Effets secondaires tardifs : Aucun effet secondaire durable n'a été noté, en particulier aucune évolution chéloïde.De rares irrégularités cutanées ont été parfois visibles sur les paupières inférieures pendant quelques mois.Résultats : L'amélioration de la trophlicité et de la tonicité cutanée a été notée chez la plupart des patients, débutant deux mois aprèsle traitement et se poursuivant sur un à deux ans minimum (follow-up de 27 mois).Discussion : Bien que les résultats soient difficilement objectivables, il nous a semblé important de rapporter cette première série detraitements avec Isolagen ® en utilisant cette technique d'injection. En effet, les premières publications rapportent des résultats à courtterme avec une technique de comblement et non par des injections sur toute la surface du visage.Il serait intéressant de procéder à une étude prospective, en incluant une troisième personne neutre pour l'objectivation des résultats,45