FINAL PROGRAM 6TH EDITION - EuroMediCom

Cross-sectional studies indicated that T level was significantly lower in men with type 2 diabetes. Men with higher T levels withinreference range had 42% of lower risk for type 2 DM.The inverse correlation was found between serum T level and BMI, visceral obesity and prevalence of metabolic syndrome. Men inthe upper tertile of serum T have lower risk of having 3 or more features of the metabolic syndrome independently of age. Higher Tlevels within reference range of older men are associated with better insulin sensitivity and reduced risk of the metabolic syndrome.There are valuable studies concerning influence of serum T levels on the range of mortality. It was found, that in men endogenous Tconcentrations were inversely related to mortality due to cardiovascular disease and other causes.The optimal situation is observed when serum T level is in the higher quartile of the reference range. The progressive prevalence inmortality may be noticed at lower quartiles of the reference range. This is suspected that the lowest quartile of serum T level may beconnected with the highest risk of mortality.Osteoporosis is a significant problem in older men. In the study 52% of elderly with low bioavailable T levels had BMD levels belowthe young adult normal range.Based on clinical studies it was established that elevation in the serum level of T was related to decrease in prostate cancer risk.Conclusion: There is a strong support to treat serum testosterone levels within the reference range in men with clinical symptoms oftestosterone deficiency.Khaw KT, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Day N. Endogenous testosterone and mortality due to all causes,cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study.Circulation 2007 Dec 4;116(23):2694-701 Clinical Gerontology Unit box 251, Addenbrooke's Hospital CambridgevbCB2 2QQ, UK.Blouin K, Despres JP, Couillard C, Tremblay A, Prud'homme D, Bouchard C, Tchernof A. Contribution of age and declining androgen levels to featuresof the metabolic syndrome in men. Metabolism. 2005 Aug;54(8):1034-40. Molecular Endocrinology and Oncology Research Center, Laval UniversityMedical Research Center, Quebec, CanadaMohr BA, Guay AT, O'Donnell AB, McKinlay JB. Normal bound and nonbound testosterone levels in normally ageing men: results from theMassachusetts Male Ageing Study. Clin. Endocrinol. 9Oxf). 2005 Jan;62(1):64-73Zitzmann M, Faber S, Nieschlag E. Association of specific symptoms and metabolic risks with serum testosterone in older men. J Clin EndocrinolMetab. 2006 Nov;91(11): 4335-43 Institute of Reproductive Medicine of the University, Domagkstr. 11, Munster, GermanyYeap BB, almeida OP, Hyde Z, Chubb SA, Hankey GJ, Jamrozik K, Flicker L. Higher serum free testosterone is associated with better cognitive functionin older men, while total testosterone is not. The Health In Men Study.: Clin Endocrinol (Oxf). 2007 Sep 20. School of Medicine and Pharmacology,University of Western Australia, FreemantleHospital, Freemantle, Western AustraliaGillett MJ, Martins RN, Clarnette RM, Chubb SA, Bruce DG, Yeap BB. Relationship between testosterone, sex hormone binding globulin and plasmaamyloid beta peptide 40 in older men with subjective memory loss or dementia. J Alzheimers Dis. 2003 Aug;5(4): 267-9. Department of Endocrinologyand Diabetes, Freemantle hospital, Western AustraliaMoffat SD, Zonderman AB, Metter EJ, Kawas C, Blackman MR, Harman SM, Resnick SM. Free testosterone and risk for Alzheimer disease in oldermen. Neurology. 2004 Jan 27;62(2):188-93. Laboratory of Personality and cognition, National Institute on Aging, Intramular Research Program,Baltimore, USAMakhlouf AA, Mohamed MA, Seftel AD, Neiderberger C. Hypogonadism is associated with overt depression symptoms in men with erectile dysfunction.Int J Impot Res. 2007 Aug 16. Department of Urologic Surgery, University of Minnesota, Minneapolis, USATivesten A, Mellstrom D, Jutberger H, Fagerberg B, Orwoll E, Karlsson MK, Ljunggren O, Ohlsson C. Low serum testosterone and high serum estradiolassociate with lower extremity peripheral arterial disease in elderly men. The mrOS Study in Sweden. J Am Coll Cardiol. 2007 Sep 11;50(11): 1070-6.The Wallenberg Laboratory for Cardiovascular Research, Goteborg University, SwedenFukui M, Ose H, Kitagawa Y, Yamazaki M, Hasegawa G, Yoshikawa T, Nakamura N. Relationship between low serum endogenous androgenconcentrations and arterial stiffness in men with type 2 diabetes mellitus. Metabolism. 2007 Sep;56(9):1167-73 Department of Endocrinology andMetabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, JapanTurhan S, Tulunay C, Gulec S, Ozdol C, Kilickap M, Altin T, Gerede M, Erol C. The association between androgen levels and premature coronary arterydisease in men. Coron Artery Dis. 2007 May; 18(3):159-62. Department of Cardiology, Ankara University School of Medicine, Ankara, TurkeyYP Teoh, AM Wallace. Population reference ranges for plasma testosterone and calculated free testosterone in older men. Endocrine Abstracts(2006)12 P104. Department of Clinical Biochemistry, Glasgow royal Infirmary, Glasgow, United KingdomSvartberg J, von Muhlen D, Mathiesen E, Joakimsen O, Bonaa KH, Stensland-Bugge E. Low testosterone levels are associated with carotidatherosclerosis in men. J Intern Med. 2006 Jun;259(6):576-82.Department of Medicine, University Hospital of North NorwayDobrzycki S, Serwatka W, Nadlewski S, Korecki J, Jackowski R, Paruk J, Ladny JR, Himle T. Assessment of correlations between endogenous sexhormone levels and the extensiveness of coronary hart disease and the ejection fraction of the left ventricle In males. J Med Invest. 2003 Aug; 50(3-4):162-9. Department of Invasive Cardiology, Bialystok University Medical Center, PolandDing EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis.JAMA 2006 Mar 15;295(11):1288-99.Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard MedicalSchool, boston, Mass, USASelvin E, Feinleib M, Zhang L, Rohmann S, Rifai N, Nelson WG, Dobs A, Basaria S, Golden SH, Platz EA. Androgens and diabetes in men: resultsfrom the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care. 2007 Feb;30(2):234-8. Department of Epidemiology,Johns Hopkins Bloomberg School of Public Health, Baltimore, USAChen RY, Wittert GA, Andrews GR. Relative androgen deficiency in relation to obesity and metabolic ststus in older men. Diabetes Obes Metab. 2006Jul;8(4): 429-35. Department of Medicine, University of Adelaide. AustraliaMuller M, Grobbee DE, den Tonkelaar I, Lamberts SW, van der Schouw YT. Endogenous sex hormones and metabolic syndromein aging men. J ClinEndocrinol Metab. 2005 Aug; 90(8):4979, 2005 May;90(5):2618-23. Julius Center for Health Sciences and Primary Care, University Medical CenterUtrecht. The Netherlands.ANTI-AGING MEDICINEHYPOTHYROID PATIENTS WITH LABORATORY TESTS WITHIN REFERENCE RANGESPATIENTS HYPOTHYROÏDIENS AVEC DES TESTS THYROÏDIQUES DANS LES LIMITES DE RÉFÉRENCETHIERRY HERTOGHE(BELGIUM)In many countries, the majority of physicians only treat patients for hypothyroidism when a patient's lab tests are clearly below thelower limit of the reference range for serum free T4 and the serum TSH level clearly above the upper limit .Only a small group of individuals get thyroid treatment, while more may need treatment. Indeed, much often recent data is found thatprofoundly question the adequateness of treating with thyroid supplements only patients whose lab tests clearly outside of thereference ranges.Reference ranges are only statistical ranges that show between what levels the thyroid hormones or TSH of 95% of a population aresituated. They do not and never have been meant to become barriers that sharply delimit thyroid health and illness.The typical thyroid laboratory tests only check part of the thyroid axis, and in particular not the distal end of the thyroid axis that deals97