Summary of HIR Equipment (2012-2013) - High Impact Research

Summary of HIR Equipment (2012-2013)NoPTjOriginal (RM)Request (RM)Total Budget Approved (RM)2012 2013 Total- before VM Lab -2012 2013 Total1 MEDICINE 10,962,035 996,025 11,958,060 10,841,560 9,938,200 735,100 10,673,3002 ENGINEERING 5,482,771 2,287,500 7,770,271 7,849,071 5,372,171 2,656,900 8,029,0713 SCIENCE 10,910,735 1,665,800 12,576,535 12,121,526 10,334,676.00 1,605,800.00 11,940,4764 DENTAL 425,000 10,000 435,000 435,000 415,000 0 415,0005 COMPUTER SCIENCE 300,500 359,000 659,500 659,500 445,150.00 203,350.00 648,5006 CHANCELLORY 36,806,500 800,000 37,606,500 37,896,500 36,405,650.00 755,000.00 37,160,650Total Per Year : 64,887,541 6,118,325 71,005,866 69,803,157 62,910,847 5,956,150 68,866,9977Kerja-Kerja Awam(approved at VM Lab) 600,00069,466,997Balance : Balance :1,202,709 1,538,869Balance = Original - RequestBalance = Original - Approved- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF MEDICINE)No PI's Name Project Title EquipmentsEstimated BudgetYear 2 & 3(2012-2013)2012(RM)Approved Budget(After VM Lab)2013(RM)Total(RM)QuantityCountry ofOriginDetailsJustificationAdditional information(space/utilities eg electric, software etc)Potential users/researchgroupsFrequency andintensity of usage1 Prof. Dr. AdeebaKamarulzamanMitigating the malayasian HIVepidemic through acomprehensive researchprogram(CERIA)1 E3--20c Freezer 14,000 14,000 - 14,000 1 USA -20 and -80 freezers are required for the storage of clinicalMany additional staff (RA and students) have been employed to work on the various projects Lab space available to accomodate these freezers.specimens.under the HIR grant. We need to provide these personnel with properly equipped workingenvironment which includes computing hardware for data analysis and additional labworkbenches . These equipment/items by themselves will not lead to Tier 1 publications but are2 E4--80C Freezer 71,000 71,000 - 71,000 1essential to create a condusive working environment that will encourage good research outputs.3 E16-CO2 Incubator 25,000 25,000 - 25,000 1 USA To stabilise CO2 environment which is essential for cell culture work. This equipment is essential for cell culture work which is required for a number of assays related Lab space available in ITL to accomodate the incubator.to the HIR projects. We currenly only have a single incubator which cannot accommodate theadditional projects and experiments. The lack of an additional incubator will significantly impedethe progress of our experiments and affect the ability to publish our results in a timely manner.2 Prof. Dr. SazalyA.BakarGenomics and molecularcharacterization of TropicalInfectious (TIDREC)4 E29-Luminex 450,000 450,000 - 450,000 1 USA Luminex system is a multiplexing platform capable of performing qualitative Multiple projects in CERiA need the measurement of various cytokines which is an essential Lab space available in ITL.and quantitative analysis of proteins and nucleic acids in a variety of sample parameter in all immunological studies. Without them, explanation of immunological mechanismswill merely be a speculation and will significantly impact our ability to publish our research in tiermatrices, greatly reducing input of precious sample, reagents and labor1 journals.while improving productivity.Various office equipment including 5 E31-Benches, Filing Cabinets, Sinks, etc 1,500 0 - 0 1 VARIOUSdesktop and laptop computers, Many additional staff (RA and students) have been employed to work on the various projectsprinters with scanning and fax capability). Additional lab benches and under the HIR grant. We need to provide these personnel with properly equipped workingsinksenvironment which includes computing hardware for data analysis and additional lab8,000- 8,0006 E21-Workstation HP2200 5,000 1workbenches . These equipment/items by themselves will not lead to Tier 1 publications but are7 E34-Desktop Computers 6,000 1essential to create a condusive working environment that will encourage good research outputs.8 E32-Printer/fax/Scanner 1,000 1,000 - 1,000 19 E35-laptop Computers 9,000 6,000 - 6,000 110 E36-Software 9,000 0 - 0 1 Software include SPSS (full package), GraphPad Prism, Gatelogic, These softwares are essential for data analysis and statistical analysis. Many of our research Most of the data analysis softwares are provided free only in the first yearFACSDiva, Trustport encryption and antivirus software.databases contain confidential patient information. Therefore there is a need for an additional and need to be subsequently purchased.level of security with antivirus and encryption softwares for the computers and portable storagedevices that hold these data.591,500 575,000 0 575,000450,000 450,000 - 450,000 1 E3-RTCA Realt time cellular analysis for HVPs 1 Switzerland For real-time study of cell impedance. It allows real-time monitoring of cellular processes occurring Comparable equipment is in Pharmacology but not in biocontainmentimmediately upon virus infection. This will then provide information to allow the user to make informed facility. This equipment is dedicated only for drug discovery studies and nodecisions on the downstream experiments e.g. timing of certain manipulations or treatments. provision for infectious disease work. The exiting equipment is firstgeneration model with no possibility for upgrading. Besides that, the exitingAdditionally, it provide important quantitative information on the biological status of the cells includingequipment is only for drug discovery studies. So the equipment that wecell number, viability and morphology.purchase will enable work in infectious disease for real-time examinationwhich will then provide information to allow the user to make informeddecisions on the downstream experiments e.g. timing of certainmanipulations or treatments.For real-time multianalytes screening upon virus infection belonging to Risk2 E4-Cellomic HTS for multianalyte cell content750,000 750,000 - 750,000 1 US For real-time multianalytes screening. It provides knowledge about targets and compounds of interestanalysis for HPVsin the context of the cell. The results obtained will allow the user to understand the biological processes Group 3 pathogens.. There are at least 11 researchers that could use thisoccuring, which will then add to the knowledge of targets and pathways of interest.equipment if it is equipped for infectious disease.3 E11-Liquid Nitrogen Tank 10,000 5,000 5,000 10,000 1 Malaysia For long-term storage of cells and samples1,210,000 1,205,000 5,000 1,210,0003 Prof. Dr. Hany Ariffin Cancer research in Malayasian 1 E20-AutoMACS Pro Cell Separator 250,000 230,000 - 230,000 1 Germanypopulation(UMCRI)(Miltenyi Biotec)This equipment will primarily be used for cell culturing purposes. Prior to the main step, proteins andvarious cells must first be purified and isolated for culturing purposes. This appliance enablespurification of mRNA and cDNA synthesis as well as genome related works. The cell separator alsofunctions as a stem cell purifier. as mentioned earlier, with the main use mostly associated with cellculture activities, probability of sharing this equipment is highly unlikely due to the existent risk ofcontamination by cancer cellsThe equipment is of low maintenance and requires no specific software torun on. Space is readily available currently for placement of the appliance inthe laboratory.4 Prof. Dr. Onn HajiHashimThe use of acute phasereactant proteins as cancerbiomarkers (UMPCR)2 E24-Pipettes 7,500 7,500 - 7,500 1 MalaysiaLiquid handling(Eppendorf)257,500 237,500 - 237,5001 E1-Protein Array Scanner 330,000 330,000 - 330,000 1 The scanner provides flexibility and reproducibility for a range of diverse This equipment is necessary to address the objectives of the proposed project. The new advance No issue with space and electric requirement. The image analysis software ismicroarray applications and format sizes. It is automated, high throughput, technology of protein microarray provides a wide variety of proteomics application, which includes: included with the whole system.and includes numbers of flexible features, including parallel dual-channel micro multi-analyte immunoassays, protein-antibody, antibody-protein, antibody-antigen, proteinprotein,and protein-drug microarray assays. The open system also allows acquisition of data anddetection and the ability to operate with a wide excitation range and a hugeselection of additional fluorescence emission filters. The scanner comes expression analysis from a wide range of gene array chips (whole human/mouse genome or specificwith inbuilt image analysis software, which supports its flexibility,group of genes). Analysis of multiple assays in a single run could greatly reduce the time consumption,automation and batch processing capabilities.number of sample and cost compared to conventional method. Protein Array also benefit from lessercross reactivity of antibody binding since each spot contains only single type of antibody. The systemwill be particularly useful for genomics and proteomics researchers within the Faculty of Medicine andUniversity of Malaya.5 Prof. Dr. Mohd RaisMustafaMolecular mechanisms ofdrug actions330,000 330,000 - 330,0001 E4-Real time PCR 200,000 200,000 - 200,000 1 USA Real-time PCR machine will be used to perform genes amplification which is Currently, 4 units is being purchased by FOM to cater to various research groups in variousThis equipment requires minimal maintenance and space is available at thea common method used in all molecular work for validation and real-time departments of FOM. In view of the increased in number of research groups and postgraduate students department for equipment placement.quantification of genes expression. This method is expected for any good in FOM. This number is still inadequate because one run takes 4 hours, which means in a day, at mostpublication and many researchers now have replaced the traditional semiquantitativethe equipment can do about 4 runs, hence, only 1 student from 1 research group can use 1 equipmentmethod with real-time quantitation.at a time, considering that the student will need the initial 2 runs to optimize amplificationparameters. In many experiments, usually a minimum of 5-10 genes are studied and this can alsoinvolves 100-200 patient samples such as that in pharmacogenomic studies. Hence, there is a need foran additional unit in Pharmacology department, not only to cater to the molecular work of this projectbut also to be used for other research groups in the department. Without this equipment, there will bea long queue to use the present number of equipment and this will delay the experiment and may alsojeopardize sensitive samples.200,000 200,000 - 200,000- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF MEDICINE)No PI's Name Project Title EquipmentsEstimated BudgetYear 2 & 3(2012-2013)2012(RM)Approved Budget(After VM Lab)2013(RM)Total(RM)QuantityCountry ofOriginDetailsJustificationAdditional information(space/utilities eg electric, software etc)Potential users/researchgroupsFrequency andintensity of usage6 Assoc. Prof. Dr. Tunku Improving articular disease 1 E6-Motion capture systemKamarulprediction and management,regenerative therapy andsarcoma management2 E7-MIMICS Visual 3D software(NOCERAL)3 E8-Softwares (Sigma plot, SPSS, etc.,)250,000 320,000 - 320,00041,000 0 - -35,000 0 - -1 This instrument is required to quantify the baseline movement pattern. Data obtained will beinformative and used to determine the root cause of injuries and to develop a treatment plan.1 Required to process and edit the 2 D image data (CT, micro CT, MRI etc.,) to construct 3 D models withatmost accuracy and flexibility.1 Statitical softwares are required to analyse and validate the genereated experimental datas , makecomplex graphs and illustratrions for a better publication.4 E9-Inverted microscope5 E10-3D Surface Scanner20,425 20,500 - 20,500160,000 - 120,000 120,0001 To view live cells by allowing the entire environment upon which the organism resides on to themicroscope stage.1 Required to analyse a real-world object or environment to collect data on its shape and possibly itsappearance. Data obtained can be applied to design orthotecis and prostehetics for clinical use.6 E11-Mechanobiology station 81,000 - 81,000 81,000 1 A platform to conduct all experiments related to mechantransduction.7 E12-Portable cutting unit 30,000 - 30,000 30,000 1 Requried to cut the hard bones for biomechanical and histological analysis.8 E13-Shaking incubator40,000 - 40,000 40,0001 Required for mixing or biological liquids as wellas the incubation and cultivation of bilogical samples.9 E21-CO2 Incubator 14,025 - 14,100 14,100 1 To grow the cells in a temperature and Co2 controlled environment.671,450 340,500 285,100 625,6007 Prof. Dr. Awang Development of spatiotemporaldengue modelresearchers.1 E2-12 workstations 40,000 34,000 - 34,000 1 Taiwan Computer workstation to be used for modelling by doctoral students and Math modelling and computer simulation of models.Bulgiba&infectious disease meta- 2 E7-segmental body composition analyser 120,000 60,000 60,000 120,000 1 Japan Bio-electrical impedance analyser to be used for measuring body fat Measurement of body composition for modelling cardiovascular diseases.analysis (JULIUS)and water composition.Space has been made available. We do not have enough workstations at themoment .We need this to carry out surveys on body composition. We do not have anysuch analyser in JCUM at the present moment.3 E9-freezer 90,000 45,000 45,000 90,000 1 USA 80 degree below zero freezer fo storing biospecimens. Storage of frozen biomarkers. There is insufficient storage space in the current freezers. We will put thefreezer in a common space and will be used by all investigators involved inthis project.4 E10-LCo2 back up system 30,000 - - - 1 USA Liquid carbon dioxide system as backup for freezer. Backup system for frozen biomarker samples. This is a backup system for the freezers.280,000 139,000 105,000 244,0008 Dr. Puteri Shafinaz Shared Equipment for Faculty 1 E1-Quadrupole-TOF Mass spectrometer 2,850,000 2,750,000 100,000 2,850,000 1 USA The equipment is a hybrid of liquid/chip separation system and quadrupole The equipment is very crucial for the HIR projects that it will be supporting.A designated lab space is available in the Proteomics Facility, MedicalAkmar Bt Abdul (central Facility)TOF mass spectrometer. It is capable of performing high throughput Acquisition of accurate mass for identification of proteins, metabolites and characterization of PTM Biotechnology Laboratory, Faculty of Medicine which currently houses theRahmantandem MS analysis (scan MS/MS sensitivity and full MS3 capabilities). modification requires high quality data from mass spectrometry analysis and a comprehensive MALDI-TOF MS. The room has been equipped with two air-conditioning unitsDetection of protein, peptide and metabolites at low femtogram-level database is an integral part of these projects. This level of analysis can only be achieved with the for round the clock temperature control for MS equipment. Electrical voltagesensitivityavailability of the QTOF instrument and software package.supply to meet the requirement of the new MS will be arranged with UM’sDynamic range and mass sensitivity performance : 2ppm mass accuracy.electrical engineering unit.High speed data acquisition rate: 50 spectra/second for The Chip LC system The instrument proposed integrates HPLC Chip separation directly on-line to the high resolution QTOF Protein mass identification search engine, post-translational patternis ideal to study protein at post-transcriptional modification level where it system. This allows high speed spectral acquisition rates permitting in depth coverage of samples that prediction software and proprietary database for known glycoproteins andallows in-depth characterization of alteration of protein glycosylation and can be analyzed in a shorter experimental time compared to conventional LC spotter-MALDI. The chip- phosphoproteins are included with the purchase of equipment. In the tenderphosphorylation. The system also allows relative quantitative analysis of MS interface is specifically designed to enhance the LC-MS/MS workflow where it allows PTMwe will ensure that future software/database update will be provided at noproteins using isotope- labeled and non-labeled approaches.investigations which is presently the cutting-edge technology in proteomics research.cost for the next 3 years. Without this equipment, many research projectsWithout this equipment, many research projects will be delayed and this will impede the process of will be delayed and this will impede the process of high quality datahigh quality data acquisition that is needed for publication in Tier 1 journals inacquisition that is needed for publication in Tier 1 journals in proteomicsproteomics/metabolomics research.research.The system proposed is not specific to the needs of one group and can be used for a wide range ofapplication being proteomics/metabolomics/glycomics/lipidomics. It will also be able to support thegrowing number of users that are requesting for an alternative approach to move from gel-based toliquid-based proteomics platform.2 E2-High Definition Low Vacuum Scanning1,100,000 1,100,000 - 1,100,000 1 USA Scanning electron microscopy (SEM) is an important equipmentPresently, there is a high request from FOM users for SEM services : average 3-4 students/week. All the An allocated space (20' x 25', temparature 15-20°C, Humidity - 60% or less)Electron Microscopyin many multi-facet analysis involving cellular and extraSEM experiments and research done by the students have to use the equipment in other faculty or for installation of the unit is already available at the Electron Microscopycellular matrix interactionuniversities. The researcher now use the SEM at ISB and IMR- however there is very long queue, it is (EM) Unit, Faculty of Medicine. The equipment will be operated by trainedresponses. The proposed equipment does not require negative pressure or time consuming and not practical to users.EM unit staff.vacuum to produce images nor processing or gold for enhance imaging. EM unit has the pre-requisites needed for sample/slide preparation prior to the viewing procedureunder SEM. Each student will need 2 days for sample preparationThere are also specific requirements of samples for live cell imaging whereby the sample must beviewed at the same place as sample preparation for optimum condition.This system proposed is intended as shared equipment under Electron Microscopy Unit, FOM. It is notspecific to the needs to one group and can be used for a wide range of applications such as in the fieldsof:• Parasitology • Oncology Research • Microbiology • Infectious Disease • Virology• Anatomy•Neurology• Stem Cell Biology•Availability of SEM at FOM will help expedite the progress of research projects and acquisition of highquality images needed for Tier 1 publication in the above mentioned research areas3 E5- Micro-CT scanner/PET scanner 2,800,0002,800,000 -2,800,000 1 United Kingdom This instrument is required to study the small animal models of diseases or In vivo evaluation in a longitudinal study is only possible with the use of this equipment. It utilizes In terms of space wise, we have allocated a space in the newly renovatedinjuries seen in humans. It will also allow anatomical, structural, functional different physical principles or fundamentals to provide unique biological information from the Electron Microscopy lab in the FOM. For the first 2 years, we'll make sureand molecular imaging of underlying subject in vivo. It allows images of underlying subject. A large range of users can use this system, with interest in either live or cadaveric that the appointed vendor absorbs the costs for full maintenance into theradiograph of calcified tissuesmodels. It also allows other users to incorporate their in vivo studies to include more sophisticated initial price. We will hire a researcher with medical physics or radiographye.g. bones, teeth etc. or contrast injected models to be imaged and studied imaging and live cell tracking when implemented within the animal. Availability of such system background to run the day to day operations on the equipment. Besides that,in close details. Images can later be reconstructed in 2-D or 3-D images with definitely leads to increase in research productivity in the following research areas:in the tender later, it will clearly stated that the future software upgrades willor without contrast. It is safe from radiation and does not require any • Oncology Researchbe provided at no cost for 3 years.specific licensing.• Infectious DiseaseFurthermore it can also include whole animal studies.• Inflammation• Metabolic Diseases• Neurology• Gene Therapy• Stem cell Biology• Cardiovascular Disease• Immunology & Transplantation Biology• Toxicology• Drug Metabolism Studies.Currently, from our own findings, there is no similar piece of equipment available in UM. Hence, thisequipment will be part of a core animal imaging facility and will serve the imaging needs of investigatorsfrom UM and other institutes in greater Klang valley. Turning down the request will introduce somedelay in the establishment of animal imaging facility. Some projects which could only be leveraged bythe requested scanner will be affected.6,750,000 6,650,000 100,000 6,750,000- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF MEDICINE)No PI's Name Project Title EquipmentsEstimated BudgetYear 2 & 3(2012-2013)Approved Budget(After VM Lab)QuantityCountry ofOriginDetailsJustificationAdditional information(space/utilities eg electric, software etc)Potential users/researchgroupsFrequency andintensity of usage20122013Total(RM)(RM)(RM)9 Prof. Dr. Fong Mun Yik Beijing Genomic Institute(Genomics and Bioinformaticservices)1 Generator Set for 2 unit of -20°C Freezer 30,000 30,000 - 30,000 1 Generator set is used to generate wide range of alternating-current (AC) This is absolutely required in order to make sure that the freezers that will hold the biobank samplessignals. It is as a back up for power supply in case of black out to ensure the from our genetic studies will always be kept at the required temperature to enable studies to continue.stability of samples.The precious samples will be accumulated over many years as new projects emerge that require the useof these samples.30,000 30,000 - 30,00010 Prof. Dr. Tan Chong Neurology Research1 E1-Inverted microscope with live imagingTincapability100,000 - 100,000 100,000 1 This microscope will enable us to analyse the localisation of various proteins To enable the imaging of dynein-ERK complexes and to visualise neuronal morphologyand the morphology of the neurons, whilst they are still alive. Live imaginghelps in understanding the behaviour of the neurons and allows theobservation of the effect that ndogenous agenst/factors have on the cells.An existing dark room will be use to house the microscope2 E2-Incubator 50,000 50,000 - 50,000 1 To provide an optimal environment for neurons to grow. To maintain neuronal cultures.3 E3-BP machine 6,110 6,200 - 6,200 1 To check blood pressure4 E5-Dissecting microscope 20,000 10,000 10,000 20,000 1 This is to provide high maginification to allow the dissection of the mouse To dissect samples under a magnifide viewercentral nervous systemE6-Vibrotome 30,000 30,000 - 30,000 1 This is for producing high-quality sections for in situ hybridisation, to enable Neural specimens needs a vibrating razor blade 5 to cut through tissuea precise determination of the expression of genes6 E8-Thermocycler 60,000 30,000 30,000 60,000 1 Thermocyclers are needed to carry out the PCRs and genetic analysis of the To enable genetic analysis to be carried out.genes of interest.7 E9-Stereomicroscope 100,000 100,000 100,000 1 For imaging work for whole mount hybridisation and for flourescent To study the surface of solid speciments.microscopy.8 E10-Computers 31,000 31,000 - 31,000 1 For miscelleneous lab use.397,110 157,200 240,000 397,20011 Prof. Dr. Mohamad UMCAS1 E1-Methadone System Database 50,000 50,000 - 50,000 1 United Kingdom We are collaborating with Ministry of Health Malaysia for Methadone supply and dispensing byHussin HabilMinistry of Health Pharmacy. At the moment we have 300 patients under the Methadone service withMinistry of Health. To add 200 another patients from Methadone Patients's waiting list, we needmachine as our pharmacies unable to coop with manual dispensing method . We can only enroll thenew patients with only the help of Methadone Dispensing Machine. We need another RM 50, 000 forthe development of the central database monitoring system of Methadone Dispensing in MethadoneClinic under University of Malaya setting (University Malaya Centre of Addiction Sciences (UMCAS),University of Malaya Medical Center (UMMC) & Ar-Rahman Mosque).2 E2-Computer Server 50,000 - - - 1 Malaysia3 E3-EEG Machine 10,000 10,000 - 10,000 1 USA Providing the raw data as an essential basis for performing the EEG analysis within this project demandsan EEG device having the minimum number of 32 channels. Regarding that the EEG device which hasbeen provided in the University Malaya Biomedical Laboratory is not applicable now and also it is ofonly 8 channels, we are in need of a new EEG measurement system for performing further analysisotherwise we are not able to receive any more patients. Furthermore, the machine is always fullybooked, so we need our own machine to ensure the data collection continuously done because we arerunning out of time.For our mission, we need to know the response of crucial region of the brain via EEG machinechannels which needs to be monitored and other instrument not enough sensitive and scientific. Wealso need the portable machine at our clinic to ensure the eeg measurement can be perform as soon asafter the patients take methadone.4 E4-Setting up Methadone Clinic 14,000 14,000 - 14,000 1 We are planning to set up methadone clinic at Department of Psychological Medicine, UniversityMalaya Medical Centre. This clinic is mainly set up to conduct MMT (Methadone Maintenance Therapy)patient in acupuncture therapy and EEG brain Signal. Therefore, we need a comfort and convenientplace for the therapy. Another reason why we need to set up methadone clinic is, current UMCAS clinicat 9 Jalan 12/5 PJ will be demolished for health metropolis project, so there is no place for us toconduct the treatment. Our place at Mosque Ar-Rahman also limited to put acupuncture and EEGmachine.124,000 74,000 - 74,000Total10,841,560 9,938,200 735,100 10,673,300 46Rejected after VM Lab- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF ENGINEERING)Approved BudgetNoPI's NameProject TitlesEquipmentsEstimated BudgetYear 2 & 3(2012-2013)2012(RM)(After VM Lab)2013(RM)Total(RM)Quantity/Uni Country oftOriginDetails Justification of Purchase Additional Information (space/utilities e.g. electric, software etc.) Potential users/research groupsFrequency andintensity of usage1 Prof.Dr Mohd Hamdi Precision JoiningAbd ShukorTechnology1 Laser welding machine 200,000 200,000 - 200,000 1 GERMAN Laser beam can join workpieces at the surface or produce deep welds.It can be combined with conventional welding methods The machine proposed has low maintenance that eliminate the usage of gas during operation The laser welding machine to purchase has been selected and supplier has been contacted. Broad users including students and researchers from Frequently used (5 days per week) and each run will take atand, additionally, be used for hybrid joining.like the conventional laser machine. This machine can do laser welding in micro scale. The The operating software is included inside the quotation received. This machine need to be materials and manufacturing fields. At least 2 PhD and least 3-4 hours.machine is available in other institutions, however the scale is not in microscale. The available place at air conditioning room. This is a medium size equipment and space is available in 4 MSc students will be trained using this machine,old laser welding machine in the department has already broken and cannot be fixed as the Surface Lab. Training cost is included in the budget.producing results that could be published in Tier-1company maker has already been shut down. Therefore the need for this machine is veryjournals including Science and Technology of Weldingcrucial for this research because the process of laser joining can only be done using thisand Joining, Applied Physics B: Lasers and Optics,machine.Optics and Lasers in Engineering and others.2 High vacuum furnace 220,000 220,000 - 220,000 1 Canada A high vacuum furnace is a type of furnace that can heat materials to very high temperatures and carry out processes such as This machine will help in reducing time for experiment as multiple sample can be setup inside The purchasing process of this machine is at acquiring information from supplier. Research Broad users including students and researchers from Frequently used (3 days per week) and each run will take 24brazing, sintering and heat treatment with high consistency and low contamination.the furnace during operation.The current vacuum furnace can only process a sample in two members has identify the selected model and supplier to supply the furnace. The machine materials and manufacturing fields. At least 3 PhD and hours.day.The machine is equip with circulated cooling system unlike existing vacuum furnace which can be operate in normal room temperature. Space is available in Furnace Room. Training 5 MSc students will be trained using this equipment,uses mass amount of water for cooling system which is not cost effective. This also the most cost is included in the budget.producing results that could be published in Tier-1suitable vacuum furnace for brazing operation. The available machine are also not stable asjournals including Journal of Alloys and Compounds,the temperature keep flactuated .Materials Characterization, Materials Science andEngineering A and others.420,000 420,000 - 420,0002 Prof. Ir Dr.Mohd Zamin Synthesis Of Blast ResistantJumaatStructures1 Dynamic Data Logger 90,000 - 90,000 90,000 1 Austria/USA An internal 4 GB Flash-disk stores acquired dataWe need to collect different type of data: images, video clips, numerical and alphanumeric- A 30 GB ' automotive' hard-disk is also available as an optionfields, free text comments, date, time, location, etc.- Further data sources like GPS and CAN-bus can be acquired synchronized with analog and-It has a DVD-CD-RW drive as standard, to burn gigabytes of dataTouch-screen facility to capture data in real-time and/or post-event modedigital data. These features are powered by DEWESoft, data acquisition software which- USB 2.0 interfaces to transfer data to another computerIt is also useful to read GPS input via an additional GPS logging utilitydisplays and stores data continuously and/ or triggered with pre- and post information.- The DEWE-201 can be connected to other PCs or NotebooksHighly customisable and can be easily modified to address vastly different data recording and- The integrated Pentium CPU offers enough calculating power to do even complex online-mathematicsreporting needs.- The system has been verified according to several EN standards. For extreme applications,- Each of up to 16 input channels can be sampled individual from 1 up to 500 kS/ s, with 16-bit resolutionTo publish in Tier 1 journal, we need to have dynamic datalogger as it is useful in fatique a wide temperature range from -20 C to + 50 C has been proven.-The input channels can be configured for voltage / current, ICPï bridge and strain gage measurementsloading test.-For DSA applications ( Dynamic Signal Analysis) , an alternative A/ D converter with 24-bit resolution, more than 110 dB-The new DEWE-201 fits perfectly into any mobile application, where fast ( and slow) datadynamic and 200 kS/ S per channel is available as an option.acquisition is required. To name just some examples: brake test in vehicles, mobile shock--In addition to digital input and counter / encoder channels, up to several hundred quasi-static channels are available ( e.g. forand vibration tests, fault recorder, high-speed data logger, and many more.temperature measurements) .Analog is just the beginning2 Blast pressure gauges 36,000 0 36,000 36,000 10 USA Kulite HKM blast pressure gauges, with pressure ranges from 100kPa - 100MPa During blast there will propogation of shock waves and these waves cause vibration and shock Description of the pressure vs. time curve. Spatial and transient change in positivein the structure. The waves need to be measured. Blast pressure gauges are meant for duration and peak pressure. Flash diaphragm type transducers, relative position to blastmeasuring the blast gauges.Electrical resistance dynamic type strain gauges were used to wave measuring device type (strain gauges, LVDTs. piezo electric,) used for measuring blastmeasure the tensile strain in the reinforcement and pressure bars (load cells) in the dynamic pressure waves (positioning and protecting the gauge, amplifying the signal, establishingtests.pressure profiles)A strain gauge is device which experiences a change in resistance when it is stretched orstrained. As strain is applied to the gauge, the shape of the cross-section of the resistance wiredistorts, changing the cross-sectional area. As the resistance of the wire per unit length isinversely proportional to the cross-sectional area, there is a consequential change inresistance.There are two basic types of displacement transducers which are based on the change ofoutput voltage as a result of specimen displacement. The number of specimens to be tested isexpected to be around 20 to 30. Thus, we need more gauges.3 High speed laser distance142,000 142,000 - 142,000 10 GermanyIt is used to evaluate the real changes of the element being subjected to blast load. It isgauges- Laser sensor up to 10 kHz measuring range 0.5-400generally placed at certain distance from the blast load so as to mearure the strains/stresses, - Laser sensor up to 10 kHz measuring range 0.5-400- Small sensor head due to separated electronic modulemonitor relative displacement etc.- Small sensor head due to separated electronic module- Independent from object surface, bright and dark.In all blast test this instrument in recommended as the gauges can't be fixed to the test - Independent from object surface, bright and dark.- Very precise and fast measuring due to special analog moduleelement. In structural engineering study of displacement measurement needs this type of - Very precise and fast measuring due to special analog module- easy adjusting of measuring frequency and reaction time. M7 gauges by MEL Microelektronik GMBH. Range 200-800mm. gauges. The number of specimens to be tested is expected to be around 20 to 30. The test is - easy adjusting of measuring frequency and reaction time. M7 gauges by MELFrequency up to 10kHzexpected to be conducted in UPNM facilities. It is possible such gauges get damaged during Microelektronik GMBH. Range 200-800mm. Frequency up to 10kHztest due to debris so we need to have few additional gauges.4 High speed digitaloscilloscopes50,000 50,000 - 50,000 3 USA/Netherland318,000 192,000 126,000 318,000MS420 20 MHzThis equipment is necessary to measure and regulate the waveforms during the test. Also the AC/DC voltage, 400mV, 4V, 40V, 400V.-20 MHz bandwidthamount of waveforms at any time is required to be recorded for comparison with responses of AC/DC current: 40 mA, 300 mA, 20 A.- Auto-set function optimizes the position, range, time base and triggering to assure a stable display of virtually any waveform. the structure parallely obtained. Our collaborators recommended theAutomatic cursor tracking measurement.- XY mode- Many automatic measurement: frequency, Duty cycle, Average, Peak to peak and RMS- Waveform math: Add, Subtract, Multiply and divide- Average mode for smoothing- Persistence mode for observing dynamic signals- Store and recall up to 1000 waveform screens and waveform setups- USB interface and PC software for transferring waveform and data3 Prof.Dr Mohd Ali Chemically And1 Chemical Vapor Deposition95,000 95,000 - 95,000 1 Germany/ CVD process is utilised to produse carbon nanomaterials by deposition of carbon atoms in gas pase on catalyst at high Carbon nanomaterials (CNMs) will be produced by the CVD reactor to be involvedLab space available in blok W or blok VHashimElectrochemicallyReactor (CVD)Malaysia temperatures (500-1200 oC). It consists of quartz tubular reactor in a tubular furnace, closing flanges, gas flowmeters, inhetrogenious catalyst applications with ionic liquids. The CNMs properrtiese are affected byGenerated Superoxide Ionstainless steel piping. The system will be assembled in the lab of faculty.the production conditions. It is essential to use CVD system to optimize the productionIn Deep Eutectic Solventsconditions which satisfy the certain application, it is expected to produce good papersAnd Ionic Liquids And Theirpublishible in Q1 journals such as CARBON.Applications2 Multi unit Bio reactor 88,000 88,000 - 88,000 Malaysia/USA/G Production of Biodeisle with ionic liquid catalysts and DES separation and purification require semultinious processes.to The Bioreactor for this applications is not available in UM. However this system is important to Lab space available in block W (W1-03) for this instrument:ermany reduce the time of optimization. Multiunit reactor with exchangeable stirrers and other operating system, its performance is produce data for kinetics and operational optimizaton useful for Q1 such as Bioresourcesimilar to that of a small laboratory fermentor and to obtain the data by applying the same time parameter to starting and journal publication in the field of palm oil processing.finishing experiments by 6 units of fermentor at the same time.This arrangement is economic by applying small vessels with small volume of medium for various experiments. Two-fourperistaltic pumps automatically control the addition of corrective reagents. Temperature control is accomplished via heatingsystem and cold finger which can freeze.Researchers working on Nanocatalyst preparation ( Dr. when the work starts, it should be operated 5 times per weekMohammed Abdulrahman , Adeeb Hayyan (PhDcandidate) )Biodeisle researchers ( Adeeb Hayyan, Maan Hayyan 5 days a weekand Kaveh Shabaz)3 Real Time UV-VisSprectrometer90,000 - 90,000 1 Approved at the VM LAB183,000 273,000 - 273,0004 Dr. Hazlie bin Mokhlis Study on the Impact ofSolar Energy Penetrationon the National Power Grid1 1. Real Time Digital Simulator(RTDS)400,000 400,000 - 400,000 1 Canada Real Time Digital Simulation (RTDS) is a state of the art,real time simulator for power system studies,closed loop protection Without this equipment the power system analysis cannot be verified for accuracy.As a result In the present Power Sytem Lab, there is enough space to accommodate this equipmentrelay system testing,control testing,training and research. Presently power system studies are done on stand alone commercial it will impede HIR work on Solar Energy penetration into the grid. It is expected that 3/4 Q1 with slight renovationsoftware which are not real time. With this purchase of RTDS more accurate analysis of power system can be done especially paper can be publishedSolar Energy penetration into the grid. PI ( Dr Halim ) have got experience in handling RTDS before in the work place beforejoining UMMaster and PHD students who are doing studies on Heavy usage by the researcher of power system groups.power system analysis. This include the renewableenergy connection to the grid. Besides, the RTDS canbe made available to the consultant who are doing thepower system analysis and power system protectiontesting.400,000 400,000 - 400,0005 Prof. Dr. T.M. Indra Experimental InvestigationMahliaof New Bioenergy sourcesfrom Tropical Biodiversity1 Rheometer set 190,000 - 190,000 190,000 1 Germany/ The Rheometer Calibration Fixture is designed for calibration verification and calibration adjustment of the torsion spring in This equipment is necessary to measure the way in which a liquid, suspension or slurry flowsUSA/ either the Model 280 or the Model 286 Rheometers. This instruction describes checking and adjusting the strength of the in response to applied forces. 15 Tier 1 ISI journal papers will be published. Here is some list ofNew Zealand/ torsion spring such that a known torque will produce a known deflection, (dial reading). In this calibration known weights will tier 1 ISI journal for publication. 1st Renewable & sustainable energy review 2nd biomass &Sweeden be used to produce a known amount of angular rotation of the bob shaft, or dial reading.bioenergy 3rd energy 4th fuel 5th applied energyPotential users typically involve reseachers doingenergy from biofuel. At least 2 PhD and 2 MScpostgraduate students will be trained using thisinstrument.Frequently used (3 days per week)2 Digital calorimeter 198,000 198,000 - 198,000 1 Germany/ The 6100 Continuously Compensated Calorimeter is a compact, static jacket calorimeter that operates at approximately room This machine need to define calofic value of potential bio energy souces or to measure caloricUSA/ temperature taking full advantage of modern microprocessor capabilities. The microprocessor controller in the 6100 will value of fuel sample. This equipment can help to publish 3 Tier 1 ISI journal papers. 1: EnergyNew Zealand/ automatically monitor the jacket temperature and apply the required corrections in real time. The advantages of this system 2:Fuel 3:Applied energySweeden include less water, less energy, andless hardware while still affording good precision. The 6100 model also uses the traditional removable bomb and bucketdesign. This combination along with a reasonable price makes it attractive forwaste and refuse disposal work and student instruction. Semi-Automatic Oxygen FillLike the 6200 Calorimeter, the 6100 Calorimeter has a semi-automatic system for charging the bomb with oxygen where theoxygen feed is controlled by a solenoid installed inside the calorimeter. The bomb is filled by slipping the filling hose connectoronto the bomb inlet valve and pushing the touch screen to start the filling sequence. Filling then proceeds automatically at acontrolled rate to an established operating pressure388,000 198,000 190,000 388,000Energy Efficiency laboratory (level2 Blok M)Potential users typically involve reseachers doingenergy from biofuel. At least 2 PhD and 2 MScpostgraduate students will be trained using thisinstrument.Frequently used (3 days per week)-updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF ENGINEERING)NoPI's NameProject TitlesEquipmentsEstimated BudgetYear 2 & 3(2012-2013)2012(RM)Approved Budget(After VM Lab)2013(RM)Total(RM)Quantity/Uni Country oftOriginDetails Justification of Purchase Additional Information (space/utilities e.g. electric, software etc.) Potential users/research groupsFrequency andintensity of usage6Prof.Dr Dr. Mohd Masjuki Hamdi Hj.Abd Hassan ShukorClean Diesel TechnologyFor Military and CivilianTransport Vehicles1 Computers, ProfessionalSoftware Licenses58,000 48,000 10,000 58,000 1 Malaysia Various office equipment including desktop and laptop computers are required for Research Assistant to assist their research Many newly recruit staff (RA + students) have been employed to work on the various projects Centre for Energy Sciences (level7, Engineering Tower) All researchers in this HIR group. Daily used ( 5-7 days per week)and study in a more efficient manner.under the HIR grant. Properly equipped working environment which includes computinghardware for data analysis and additional lab workbenches are required for these personnel.These equipment/items by themselves will not lead to Tier 1 publications but are essential tocreate a conducive working environment that will encourage good research outputs.2 DMS500 MKII Fast ParticulateSpectrometer3 EGR, Rotary pump, dieselparticulate filter etc.351,360 351,360 - 351,360 1 USA The particle spectrometer can be used for particle size measurement from 5 nm – 1 μm. It is used for engine emissions Without this equipment the exhaust particle size and distribution from engine cannot be Lab space available in Engine Tribology Laboratory, Department of MechanicalPotential users involve all researchers in this HIR Heavily used (5 days per week). Each time will take aboutcalibration and gravimetrically-correlated particle mass.The system is featured with fastest available time response (10 Hz measured. This will lead to unable in conducting engine emissions study. This willEngineering.group.about 30 min to a few hours.data, 200 ms T 10-90%). The system is fitted with fully integrated two-stage dilution and sampling system specifically for consequently impede HIR research work on clean diesel technology studies and the HIR Software is included.direct engine exhaust measurements.researchers will not be able to publish their work in top Tier 1 journals in this field.Researchers in UM require this equipment to study the exhaust particle size and distributionwhich otherwise no equipments is able to measure. In addition, this system is needed toaccommodate the research facilities that currently unavailable in UM.100,000 100,000 - 100,000 1 Malaysia A dedicated EGR system is required to incorporate into a diesel engine for emissions reduction, predominantly in NOx. Rotary In the absent of these systems, the engine and emission cannot be retrofitted and optimized. Engine Tribology Laboratory, Department of Mechanical Engineering. Potential users involve researchers in this HIR group. Frequently used.pump couple with electronic control system is required to provide the flexibility in fuel injection phasing. Also, various This will give an unfinished study of the clean diesel technology development. As a result, itparameters such as fuel pressure can be adjusted to optimize the engine performance and emissions. Diesel Particle Filter will impede HIR work on clean diesel technology studies and the HIR researchers will be(DPF) traps the particulate matters and burns them off in a controlled manner to regenerate the filter. It is regarded as the unable to publish quality work in top Tier 1 journals in the related field. Researchers in UMmost efficient technology to reduce PM emission. The project will develop a transient model (2D) of a DPF to investigate the need this individual system to study the engine performance and emissions characteristicsprediction of the development of concentrations, temperature, pressure, flow pattern and soot layer thickness along the filter. which otherwise no instruments is able to determine. Besides, there is no such system in UM,hence it is a bottleneck and hindering all related work in UM.4 Idling Reduction devices 120,000 60,000 60,000 120,000 1 Malaysia Idle reduction devices are used to scrub avoidable fuel consumption at engine no-load condition such as during idling in a This device is required to perform idling reduction strategy. Without this equipment, the Engine Tribology Laboratory, Department of Mechanical Engineering.traffic jam, rail-road or sea-liner in the port. The engine keeps running during these time engine and at the same time uses proposed study cannot be done and this will impede HIR work. The HIR researchers will beunnecessary fuel and emits hazardous gases. IR devices provides auxiliary support to onboard systems such as air-conditioner, unable to publish work in top Tier 1 journals in the related area. HIR researchers in UM requirelight, radiator fan etc. IR devices will be used for a specific time in a car and will be calibrated to get stable results.this device to perform the said strategy correlated with fuel economy which otherwise nodevice is capable to perform. Also, currently no such device in UM, hence it is a bottleneck andobstructing all related work in UM.5 Combustion Analyzer system 200,000 200,000 - 200,000 1 Austria/ The combustion analyzer comprises of a modular rack system interfaces with a computer serves as a basic system for pressure A Combustion Analyzer System is required to measure the pressure in the combustion Lab space available in Engine Tribology Laboratory, Department of MechanicalSwitzerlland/ (cylinder and fuel line) and crank angle measurement. It is used for engine research, development and optimization. The chamber as a function of crank shaft angle. Because of the advance and in depth of research Engineering.USA system can be integrated with a test-bed system, which receives all the calculated results. The system supports angle and time experiments proposed, a dedicated analyzer system is required. Without this equipment, it Software is included.based measurement and uses algorithms for online mathematics and statistics – calculating heat release and furtherwill impede HIR work on combustion characteristics studies and the HIR researchers will bethermodynamic parameters. The system can be used for offline calculation and the export to several file formats. It is also unable to publish work in high ranking Tier 1 journals in this area. In addition, this system issupports Video and Ethernet. In addition to combustion analysis, the system can be expanded to handle other measurement unavailable in UM, hence it is a bottleneck and hold back all related work in UM.applications such as hybrid testing on power train, noise and vibration measurement by means of different types of signalconditioners are used.6 CFPP analyzer 83,000 83,000 - 83,000 1 Malaysia This system is suited to analyze the standardized value of Cold Filter Plugging Point (CFPP). This system is suited to analyze the Without this equipment the physical properties of the fuel such as pour point, flash point and Lab space available in Engine Tribology Laboratory, Department of Mechanicalstandardized value of CFPP. The CFPP measurement is often combined with the determination of the CP, giving a better cold filter plugging point analysis cannot be determined. This will result in insufficient of Engineering.control of the base blend. Knowledge of CP temperature permits a reduction of the measurement cycle time by starting the information in conducting of fuel and engine analysis. As a result, it will impede HIR work onmeasurement at temperatures that are a few degree above CP.clean diesel technology studies and the HIR researchers will be unable to publish work in topTier 1 journals in this area. Researchers in UM require this analyzer to study the fuel propertieswhich otherwise no instruments is able to analyze. Also, there is no such instruments in UM,hence it will obstructing all related work in UM.Potential users who involve in fuel economy studies Frequently used.under this HIR group.Potential users involve all researchers in this HIR Heavily used (5 days per week). Each time will take aboutgroup.about 30 min to a few hours.Potential users including chemist and all researchers in Frequently used.this HIR group.7 HFR500 Fast FID (fastresponse HC concentrationmeasurement)145,000 145,000 - 145,000 1 Malaysia This system is able to provide valuable insights into engine operation, and assists calibration engineers in reducing the engine This equipment is required to measure the engine combustion cycle-by-cycle hydrocarbon Lab space available in Engine Tribology Laboratory, Department of Mechanicalout emissions. Also, this system can assist in emissions compliance while reducing after-treatment costs. The system is able to concentration during and after engine firing. Without this equipment, a valuable insight into Engineering.measure cycle-by-cycle HC emissions during and after start allows engineers to optimize engine calibration for cold start; engine operation cannot be determined and will lead to incomplete understanding of themaintaining startability while minimizing these highly significant HC emissions.engine. As a consequent, it will interrupt HIR research on clean diesel technology studies andthe HIR researchers will be unable to publish their work in high impact Tier 1 journals in thisarea. Researchers in UM need this equipment to study the engine emissions and combustionefficiency which otherwise no equipments is able to analyze. Also, there is no such equipmentin UM, hence it is an obstruction and restraining all related work in UM.Potential users involve all researchers in this HIRgroup.Heavily used (5 days per week). Each time will take aboutabout 30 min to a few hours.1,057,360 987,360 70,000 1,057,3607 Prof. Dr Wan MohdAshri Wan DaudBiodiesel from Pyrolytic OilProduced from Palm Shellby HydrodeoxygenationProcess1 TG-FTIR0600,000 600,000300,000 1 Japan IR Prestige-21 1 Set, IEEE Conection Kit 1 Set, Computer & Printer & UPS 1 Set, Solid sampling kit:DRS-8000A 1 Set, ATR 8000H 1 Set, Agate Mortar 1 Set, Kbr Crystal 100 gram 1 Btl, Liquid sampling kit: 1 SetDemountable Cell Kbr 1 Set, Fixed Thickness cell Kbr 0.1 mm 1 SetOnly one old unit is available in Department of Chemical Engineering and already broken, also The safety room with air conditioner facility is necessary to operate the equipment. Atnot have a good accuracy for analysis. FT-IR is an equipment used for analyze the functional present, the room is under construction (combustion lab, chemical engineeringgroup compositions in the sample. The principle FTIR is a measurement with infra-red (IR) department) and will be finish soon. Some of additional accessories need to facilitatelight. Some of department inside of UM have the FT-IR, but its take time to use because the analysis, such as:equipment is frequently used by many researchers. By buying the new unit of FT-IR, its meaneliminated some error problem from data analysis and we expected this project will be finish Miracle Ge ATR accessory (1 unit), includes; MIRacle Platform Assembly-Bruker QL,based on the schedule.MIRacle Ge Crystal Plate, and MIRacle High Pressure Clamp.The equipment is very useful for many researches inChemical Engineering Department. Normally, it usedfor characterize raw material or product yield.Each of samples that produced from the hydrodeoxygenationprocess or pyrolysis process is need to characteristic directlyby FT-IR. The use of equipment is depending on the processmanaged. However, it just used when analysis conducted.300,0001 GermanyDiffuse reflection accessory (1 unit), includes; EasiDiff MidIR-Bruker QL.Includes: 450-GC Gas Chromatograph, 300-MS Triple Quadrupole Mass Spectrometer, EI, positive & negative CI, MS/MS, high In this research, the GC needs to detect the output gas content derived from reaction of The safety room with air conditioner facility is necessary to operate the equipment. At The equipment is very useful for many researches inperformance turbomolecular pumping system, DS-42 foreline pump, PC, workstation software, gas filter, and DB-PETRO hydrodeoxygenation process. The GC will directly connect to the reactor to analysis and record present, the room is under construction (chemical engineering department) and will be Chemical Engineering Department. Normally, it usedcapillary column (50m x 0.2mm, 0.50μm). Installation and 1-year warranty.the data during the reaction. For additional information, the department of chemicalfinish soon. Without the equipment some objective of this research will be disturbed. for characterize raw material or product yield.engineering has some of GC but under different project. Currently, the research is a new fieldMS Features:of research that develops in Chemical Engineering. The use of biomass for fuels with pyrolysis The MS Workstation software controls all GC, autosampler, and MS functions. It allowsThe Triple Quadrupole mass spectrometer includes Electron Ionization (EI), Positive and Negative Chemical Ionization (PCI and and then upgraded with hydrodeoxgenation process now considered as having contribution to fully automated quantitative and qualitative analyses with standard and optional CustomNCI). MS modes includes full scan, Selected Ion Monitoring (SIM), Precursor (Parent) scan, Product (Daughter) scan, Neutral provide the projected renewable energy supplies of the future. The availability of equipment is Reports. Standard spectral libraries included are: TR (Terpenes) with approximately 600Loss scan, Single Reaction Monitoring (SRM), and Multiple Reaction Monitoring (MRM). The electron energy range available is: helping this project focus to obtain a good quality of research. The MS will use forspectra, TX (Toxicology) with approximately 1300 spectra, GP (General Purpose) with20eV, 70eV, or 150eV with a mass range of 10-2000 m/z. Vacuum interlock for quick change of ion volumes is also included. characterization of oil.about 3,000 spectra. Optional library data bases are: NIST, Wiley, Pfleger- Mauer-WeberHigh efficiency quadrupole mass filters (Q1 and Q3) incorporates pre- and post-filters. 180 degree path of Q2 places multiplierdrug and pesticide library, Rosner Mass Spectral Library of Designer Drugs, Kuhnle Massin true off-axis position from the source - improves signal-to-noise and no cross-talk for accurate identification andSpectral Library of Pharmaceuticals and Agrochemicals, and other custom libraries.quantitation for multiple compounds analysis. Electronic Pressure Control (EPC) for CI and CID gases. Multiplier employs +/-5kV post acceleration voltage for optimal ion collection. Meets and maintains EPA BFB and DFTPP tune criteria. Improved 3-Quick Access – Network access and functionality for multiple MS WorkStation systems forion ratio stability. New extended dynamic range (EDR) of up to 10^5 (compound dependent) in SIM or full scan – improveshigh-throughput analysis by expert or novice users.linearity and adjusts automatically the detector voltage for best S/N ratio. Fast (

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF ENGINEERING)Approved BudgetNoPI's NameProject TitlesEquipmentsEstimated BudgetYear 2 & 3(2012-2013)2012(RM)(After VM Lab)2013(RM)Total(RM)Quantity/Uni Country oftOriginDetails Justification of Purchase Additional Information (space/utilities e.g. electric, software etc.) Potential users/research groupsFrequency andintensity of usageProf.Dr Dr. Jaya Mohd Narayan Hamdi Sahu Sustainable treatment of11 1 Plasma reactor 100,000 100,000 - 100,000 1 China Microwave plasma reactor, in remote microwave plasma subsytems, the plasma discharge is used to dissociate process gases It is important for synthesis of high quality adsorbent from biomass. Specific plasmaPotential users typically involve chemical engineers, 325 days per yearAbd Shukorwastewater from latex andand product active atoms (radicals) upstream of the process chamber.traetment of adsorbent drive to maximal porosity, and so create a maximum number of activechemist, and scientist deals with surface treatmentrubber process industriessites where unwanted molecules can be mechnically adsorbed.research work.by biosorption process 2 HPLC pump and rapture disc10,000 10,000 - 10,000 1 Malaysia The HPLC pump required for the transport of liquid pollutants to the column. The control system arrangement for the plasma Accessories required for HPLC and plasma reactor establishment. All users in the lab. 325 days per yearLab space available in W block, Chemical Engineering department. This experimental setupand valve with control systemreactor.generates data that can be published in tier 1 ISI journals targeted number 11 and listsof journals are: 1) Journal of Hazardous Materials; 2) Bioresource Technology; 3) Biomass3 Online HPLC 30,000 30,000 - 30,000 1 Malaysia HPLC typically utilizes different types of stationary phases, a pump that moves the mobile phase(s) and analyte through the This is use for the analysis of liquid pollutants from the Colum study, where online HPLCAll users in the lab.325 days per yearand Bioenergy; 4) Chemical Engineering Journal; 5) Industrial & Engineering Chemistrycolumn, and a detector to provide a characteristic retention time for the analyte.attached.Research etc.4 Data acquisition system with30,000 - 30,000 30,000 1 Malaysia To store the data collected for HPLC after the analysis of liquid pollutants contains in waste water before treatment and after This is supporting requirement for data the storage and used for analysis for equilibrium andAll users in the lab.325 days per yearPCtreatment.kinetic study.Collection of the 5 Thermal reactor heat5,000 - 5,000 5,000 1 Malaysiahydrolysis products at normal temperature and pressure. All users in the lab. 325 days per yearexchangerTo condense the rector out vaporization product.175,000 140,000 35,000 175,00012 Assoc. Prof. Dr. NoorAzuan Abu OsmanSynthetic Prosthetic Socketthrough Stump-LinerInterfacial StressesMeasurement1 C-leg prosthetic system or119,000 119,000 - 119,000 1 USA/UK/Germa To optimize swing phase control, enhanced stumble recovery, and capture musculoskeletal signal from the patientsUM are actively doing reserach in the field motion analysis and only in the country. WithoutProsthetists, Orthotists, Bio-engineersequivalent complete withnthis equipment the kinesiology parameters cannot discriminate measurements at and beyondsoftwarecurrent state of the art equipments and will be unable to publish work in Tier 1 journals in thisarea. No such instruments in Malaysia.UM are actively doing research in the prosthetics and orthotics and only in the country.2 Automated casting system 200,000 200,000 - 200,000 1 USA/UK/Germa System that recognize the pressure-relief area and pressure-tolerance area on computer aided design model of the residualResearch groups related to artificial limb groups inn limb of the patient.Without this system the new invention on auto casting cannot be done. No such instrumentsMalaysiaLab space available in brace and limb lab.in Malaysia.3 Strain meter 100,000 - 100,000 100,000 1 USA/UK For use with custom-made transducer, load cells and strain gauge which attached to the prosthesis. This is supporting equipment will be use for instrumentation and measurument Research groups related to artificial limb groups inMalaysia4 Portable direct EMG200,000 - 200,000 200,000 1 USA/UK Wireless programmable physiological monitor for viewing and recording any combination of physiological signals such as ECG, This is supporting equipment will be use for instrumentation and measurument and integratedClinicians, Biomechanists, Bio-engineersacquisition systemEEG, EOG and EMG activity, as well as transducer inputs, such as airflow, force, and blood pressure. To evaluate physiological with motion analysis systemsignals of the patient during stance and swing phase.619,000 319,000 300,000 619,000Heavily used for every testing to patientsHeavily used 5 days a week and each usage will take 3 hours13 Prof. Dr. T.M. IndraMahliaAutomobiles Fuel EconomyStandard and Label throughImplementationPossibilities1 Dynamometer for smallengine185,000 185,000 - 185,000 1 Germany/ Testing of engine performance is often important in the development of engine and fuel technologies. Many parameters affect This equipment is neccesary to investigate fuel economy and emission of the small engine and Energy Efficiency laboratory (level2 Blok M)USA/ an engine’s performance: the basic engine design, compression ratio, valve timing, ignition timing, fuel, lubricant, and To measure performing dynamometer on Combustion Engines. This equipment can help toNew Zealand/ temperature.The most critical factor governing an engine’s power, fuel consumption and emissions is the amount of fuel publish 3 Tier 1 ISI journal papers. Here is some list of tier 1 ISI journal for publication. 1stSweeden consumed relative to the amount of air ingested. This is expressed as the air/fuel ratio; that is, the mass of air used divided by Renewable & sustainable energy review 2nd energy 3rd solar energy material and solar cellthe mass of fuel burned. Larger engines typically have computer-controlled fuel injection governing the air/fuel ratio whilesmaller engines still use carburetors for controlling the air/fuel ratio. Proper tuning of an engine’s carburetor requires carefulmeasurements of torque, speed, temperature, and fuel consumption as a function of throttle position. Agilent USB dataacquisition (DAQ) modules provide an inexpensive, fl exible solution for engine testing. To test engine performance in thelaboratory, the engine is coupled to adynamometer, which may be either an engine dynamometer (connected directly to the engine output shaft) or a chassisdynamometer (connected to the drive wheels). The dynamometer, which provides a load to the engine, can be easilycontrolled to allow testing under a wide range of speeds and torque.Potential users typically involve reseachers doing Heavy used (5 days weekly). Each sample/fuel can run up toengine testing. At least 2 PhD and 2 MSc postgraduate 12hours daily.students will be trained using this instrument.2 Upgrading and instrument ofdynamometer175,000 80,000 95,000 175,000 2 Germany/ Piper Test & Measurement manufactures engine test systems with its own product range such as the successful P1200, P2400 This equipment is neccesary to investigate peformance of the engine and to measure theUSA/ and P4000 engine dynamometers, CD1000 and CD2000 chassis dynamometers, and its associated instruments. Ourdynamometer shaft provides high accurate speed measurement.This equipment can help toNew Zealand/ instrumentation range is comprehensive and ranges from simplepublish 3 Tier 1 ISI journal papers. Here is some list of tier 1 ISI journal for publication. 1:Sweeden analogue to full computer based data acquisition systems. The majority of the basic equipment can be specified toEnergy policy 2: energy 3: fuel 5th energy conversion & mangementincorporate RS232/485 output signals.The extensive knowledge gained during hands on experience with the workings ofhydraulic, eddy current and DC absorption units, enables us to recommend an upgrade to PIPER instrumentation for existinginstallations.One-off specific test rigs are designed in close co-operation with the customer. Our knowledge of mechanical,electrical and hydraulic systems enables value for money units to be manufactured at short lead times, whilst our close cooperationwith engine manufacturers enables the most suitable test schedules to be prepared.Our co-operation withproprietary peripheral instruments manufacturers of products such as smoke density recorders and fuel flow measuringdevices, enables PIPER to offer its customers essential test room equipment.Technical back-up and assistance with peripheralservices and, if required, liaison with subcontractors, ensures that customer experiences the minimum delay once theequipment is delivered on site.The PIPER design philosophy is based on incorporating known technologies. This ensures thatthe client has reliable, serviceable and, above all, user friendly equipment.Piper Test & Measurement is onveniently situated inthe South East of England one and two hours respectively from Gatwick and Heathrow airport and half an hour from the ferryand tunnel links with EuropeEnergy Efficiency laboratory (level2 Blok M)Potential users typically involve reseachers doing Heavy used (5 days weekly). Each sample/fuel can run andengine testing. At least 2 PhD and 2 MSc postgraduate test up to 12hours daily.students will be trained using this instrument.360,000 265,000 95,000 360,00014 Prof. Dr. Saad Mekhilef Torque Ripple Reduction 1 Permanent magnet38,000 38,000 - 38,000 1 Japan/USA/Ger 10kW Permanent magnetThis motor will be used to test the the dynamic performance of the inverterand Design Optimization of synchronous motormany synchronous motor will act as load to test the inverter performanceVoltage Vector Controlled2 Dynamometer 70,000 - 70,000 70,000 USA/Germany 7.5 kW dynamometer To test the coplet system (controller, PMSM, and inverter)PMSM Drives Supplied byInnovative MultilevelInverters3 100 KW DC power supply 45,000 45,000 - 45,000 1 Japan/USA 10kW DC programmable Power supply to be used as power source of the inverter This power supply will be used as power supply to the inverterLab space available in Block M, Level 54 106A Single and Three phase20,000 - 20,000 20,000 1 Malaysia/USA/G 106A Single and Three phase power AnalyzerThis power meter will be used to test the the static and dynamic performance of the inverterpower AnalyzerermanyMaster and PHD students who are doing studies onthe related field and also the undergraduate students 2-3 times per week with 6 hours usage each time.for their projects and etc.5 AC power meter 21,000 - 21,000 21,000 1 Malaysia/USA/Germany5kw power meterWill used to measure the power and THD194,000 83,000 111,000 194,00015 Dr. Mohammed Harun Undivided Redox FlowChakrabartiBattery Reactor EmployingPorous Flow throughelectrodes and DeepEutectic Solvents1 Electrochemical Impedance20,000 20,000 - 20,000 1 Switzerland EIS is a powerful diagnostic tool that can be used to characterize limitations and improve the performance of batteries. There Currently several groups in UM are actively doing research in the field of batteries and fuel Lab space available in W-block laboratory (W1-03).This equipment will be used by one PhD student under This instrument will be used at least twice a week after theSpectrophotometer (EIS)are three fundamental sources of voltage loss in batteries: charge transfer activation or “kinetic” losses, ion and electron cells. Without this equipment the fuel cell and battery research cannot be characterised Software included. A medium size (19' rack size having weight of less than 10 kg)Prof. Azlan (Yashar Molana) to test vanadium/oxygen flow battery is fully operational. Once Yashar's fuel cell istransport or “ohmic” losses, and concentration or “mass transfer” losses. Among other factors, EIS is an experimentalsuccessfully enough such that UM could compete with other universities such as UKM. This instrument, needs air-cond and clean room which is available. Without this instrument, no fuel cells and optimise their performance. Yashar will ready, it will be used four times a week. The intensity oftechnique that can be used to separate and quantify these sources of polarization. By applying physically-sound equivalent will impede HIR work on fuel cell studies and the HIR researchers will be unable to publish battery and fuel cell research can proceed and UM will always remain behind UKM. A full run the fuel cells in order to validate his mathematical usage will increase once Yashar's fuel cell is ready andcircuit models wherein physiochemical processes occurring within the battery are represented by a network of resistors, work in the Journal of Power Sources and Electrochimica Acta. Also, there is no suchmarket survey has been done and three qualified Malaysian based companies are available models that he is preparing with a Masters student installed (by the middle of 2012). Initially the instrumentcapacitors and inductors, it is possible to extract meaningful qualitative and quantitative information regarding the sources of instruments in UM, hence it is a bottleneck and hindering all related work in UM. This who can act on behalf of the original Swiss manufacturers to sell the system to UM. The (Chen Ching Liang) at present. In addition, Laleh may be used for 6 hours in a day but once the fuel cell isimpedance within the battery. EIS is useful for research and development of new materials and electrode structures.instrument has been used several times by the PI during his PhD in Manchester and other companies also have a maintenance wing and have a good track record in dealing with UM Bahadori (a PhD student) is designing a flow battery developed, it may be used for more than 14 hours.experts are available in the Department who can help guide the students (such as Dr. Brahim in the past.based on deep eutectic solvents that needs fullSi Ali and Dr. Yeoh Hak Koon). In addition, two collaborators, Dr. Inas AlNashef and Dr. Johncharacterisation for good operation. Without thisLow are experts and can visit UM several times for training and monitoring the students.instrument, a proper characterisation will not berealised.2 Rotating disk electrode and35,000 35,000 - 35,000 1 USA A rotating disk electrode (RDE) is a hydrodynamic working electrode used in a three electrode system. The electrode rotates Currently there are no RDE systems available in UM and its inclusion would allow thePlenty of lab space available in block W (W1-03) for this instrument. Software is included This instrument will be used by Laleh Bahadori (PhD This instrument is likely to be used at least three times a weektest cellduring experiments inducing a flux of analyte to the electrode. These working electrodes are used in electrochemical studies characterisation of several electrolytes for testing in batteries and fuel cells. Laboratory scale and at least three representative companies of this American manufacturer are present in student) to characterise the electrochemical properties by both Laleh and an Undergraduate Research Student aswhen investigating reaction mechanisms related to redox chemistry, among other chemical phenomena. The more complex experiments may produce sufficient results that could be published in Electrochemistry Malaysia who have dealt directly with UM in the past. The service track record of these of different ionic liquids and deep eutectic solvents they need it to characterise different ionic liquids and deeprotating ring-disk electrode can be used as a rotating disk electrod e if the ring is left inactive during the experiment.Communications and the Journal of Power Sources. PI has used this several times during his companies have also been very good.with the aim of selecting the best for flow battery eutectic solvents. It is likely to be used for at least 6 hours inPhD and this project is supported by experts such as Dr. Inas, Dr. Low (Southampton) and Dr.experiments. Such characterisation is not possible a day.Ninie Manan (Chemistry, UM).elsewhere in UM.3 TGA + Jacketed Eurocell kit 100,000 - 100,000 100,000 1 USA Thermogravimetric analysis or thermal gravimetric analysis (TGA) is a type of testing performed on samples that determines Although some departments in UM may have a few TGA devices, their specifications don't Laboratory W1-03 also has space for a TG Analyzer (instrument supplier has facilities for Laleh Bahadori and another PhD student will use DSC This instrument is likely to be used at least three times a weekchanges in weight in relation to change in temperature. Such analysis relies on a high degree of precision in threematch the specific analysis required for ionic liquids as electrolytes in flow batteries. The installing, training and troubleshooting). Three representing companies for the American and TGA to characterise the thermal losses inby both Laleh and another PhD student once the flow batterymeasurements: weight, temperature, and temperature change. As many weight loss curves look similar, the weight loss curve effect of heat transfer, thermal losses, etc. on battery and fuel cell performance would be manufacturers are available in Malaysia and they have a good service track record with operation of flow batteries. Yashar Molana can also is designed and in full operation. It is likely to be used for atmay require transformation before results may be interpreted. A derivative weight loss curve can identify the point where monitored efficiently and mathematical modelling would be conducted such that papers of UM.test the effect of thermal strain during the operation of least 8 hours in a day and if Yashar's fuel cell is also tested,weight loss is most apparent. Again, interpretation is limited without further modifications and deconvolution of thehigh quality are published in the Journal of Power Sources. In addition, the differentialhis fuel cells.then it can go on to about 12 hours in the day.overlapping peaks may be required. To determine composition and purity one must take the mass of the substance in the thermal analysis of electrolytes during charging and discharging could indicate places wheremixture by using thermal gravimetric analysis.inefficiencies exist in batteries. As a consequence, this major problem can be solved. PI hasused this instrument and the project will be supported by Dr. Irfan (an expert and a staff inCEUM) and Arash (a PhD student of Dr. Irfan) who are experts in using TGA.16 Assoc Prof Dr Norhayati Characterization of theSoinNBTI Impact on New-AgeDeep-Submicron Devices toEffectively Predict SystemFailure155,000 55,000 100,000 155,0001Sentaurus Synopsys Simulator200,000 - 200,000 200,000 1 USATool2Keithley I-V System 61,011 61,011 - 61,011 1 USAKeithley Probe Manipulators 200,000 200,000 -1 USA3200,000461,011 261,011 200,000 461,011Over time, both NBTI and HCI degrade device currents and will cause failures in integrated circuits. Circuit designers need to This is a new scope of research in microelectronics related to advanced IC technology. This Lab space available in Block R, Microelectronics lab, Faculty of Engineering.This simulator Research groups related to VLSI Design, Circuit Design High intensityconsider these reliability effects in the early stages of design to make sure there are enough margins for circuits to function complete IC reliability simulation tool is not available in UM and other local univerisities in only needs PC or laptop to run on it and supporting by parametric extraction software for Nanotechnology. This simulator would support thecorrectly over their entire lifetime. This simulator is a complete solution, including reliability model extraction and calibration Malaysia. The evaluation of this simulation tool has been conducted in the microelectronic labcontinuation of the current research of our tutor into silicon, with Device Modeling (BSIMProPlus) and full-chip reliability simulation and analysis with Virtuoso® UltraSim FullchipSimulator.To support experimental data in order to model the degradation mechanisms of tested ICtool has the capability on supporting our experimental data to successfully create thefor 3 weeks. The capability of this simulator has been proven to support this research. ThisLJMU.reliability model. Since this scope of research is still new, any research study on this ICreliability that is being validated by the eperimental work will have a good opportunity to bepublished in ISI TIER 1 journal such as IEEE Transaction of Electron Devices. This is the currentresearch activities in IMEC, Austria. (Micro- and nanoelectronics research centerheadquartered in Leuven, Belgium)Only few old units available in UM which is old and not upgradable and unable to fulfil currentresearch needs. This has been confirmed by the probing machine and the semiconductorAs semiconductor device geometries shrink below 65 nanometers, device reliability becomes more important because of new parameter analyser application engineers during visit to Singapore. Intensive training andmaterials, structures and higher IC operating temperatures. In particular, negative bias temperature instability (NBTI) causes demo have been done in Singapore to check the capability. The PI had experienced thesignifi cant threshold voltage shift under negative bias and high temperature conditions, making it one of the most critical handling of this equipment during her postgraduate study in Liverpool John MooresResearch groups related semiconductor wafer andreliability concerns for advanced semiconductor processes. Therefore, it is essential to evaluate transistor characteristics as University (LJMU). Furthermore this project is a collaborative research project with LJMU in Lab space available in Block R, Microelectronics lab, Faculty of Engineering.device fabrication .This simulator would support theHigh Intensityquickly as possible after the stress is removed (within 1 μs) to avoid dynamic recovery effects. In addition, because the type of which our tutor is currently doing the research in UK. Currently a team of 3 phd Students andcontinuation of the current research of our tutor instress also influences the magnitude of the threshold voltage degradation and in turn, the device lifetime estimates,3 Msc students are being involved in running the experiment at IIUM. This equipments willLJMU.measurements are required not only after DC stress, but also various typesproduce the accurate results on the latest wafer technology that will be valid for theof AC stress.publication of ISI TIER 1 such as IEEE Transaction of Electronic Devices.This is the currentresearch activities in IMEC, Austria. (Micro- and nanoelectronics research centerheadquartered in Leuven, Belgium).-updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF ENGINEERING)Approved BudgetNoPI's NameProject TitlesEquipmentsEstimated BudgetYear 2 & 3(2012-2013)2012(RM)(After VM Lab)2013(RM)Total(RM)Quantity/Uni Country oftOriginDetails Justification of Purchase Additional Information (space/utilities e.g. electric, software etc.) Potential users/research groupsFrequency andintensity of usage17Prof.Dr Dr. Jaya Mohd Narayan Hamdi Sahu Production of hydrogen byAbd Shukorhydrolysis of biomass1 High pressure and high200,000 200,000200,000 1 UK Intermediate pyrolysis reactor at high temperature and high pressure IntermediatePyrolysisIntermediatePyrolysis is an advance version.Potential users typically involve chemical engineers, 325 days per yeartemperature reactorThefeedstocksthatcanbeusedarediverseandrangefromwastewoodtofoodwastesandsewagesludchemist, and scientist deals with pyrolysis and-ge.Thereisalsosolidresidue(biochar)asaproductfromthepyrolysisprocesswhichcanbeusedasafertihydrolysis of biomass and solid waste for biogasliserfortheagriculturalfields(aperfectcaseforcarbonsequestration)oritcanbeusedforcocombustiosynthesis research work.ninthermalpowerplants.Lab space available in W block, Chemical Engineering department, kinetic S/W will bepurchase. This experimental set-up generates data that can be published in tier 1 ISI2 HPLC pump and rapture disc10,000 10,00010,000 1 Malaysia The HPLC pump required for the transport of liquid oil products to the column of GC. The control system arrangement for the Accessories required forGC and high temperature reactor establishment All users in the lab. 325 days per year-and valve with control systemhigh temperature reactor.journals targeted number 17 and lists of journals are: 1) International Journal of hydrogenEnergy; 2) Bioresource Technology; 3) Biomass and Bioenergy; 4) Chemical Engineering3 GC with TCD column 90,000 90,00090,000 1 Malaysia After the components of a mixture are separated using gas chromatography, they must be detected as they exit the GC Analysis the gases product online with the reactor use for the hydrolysis process, which will bePotential users typically involve chemical engineers, chemist, 325 days and scientist per yearwho require automated detection bio- syngas research work.-column. The thermal-conductivity (TCD) and flame-ionization (FID) detectors are the two most common detectors onable to identify the components of fuel mixture and hydrogen, etc.Journal; 5) Fuel Processing Technology; 6) Industrial & Engineering Chemistry Research etc.commercial gas chromatographs.To store the data collected from GC 4 Data acquisition system with50,00050,000 50,000 1 Malaysia after the analysis of gases products from the reactor for further analysis’s . Two S/W use This is use as supporting requirements for process and experiment data storage and analysisAll users in the lab.325 days per year-PCfor store process parameter data and for kinetic analysis of data.for equilibrium and kinetic study.5 Gas flow meter 25,000 - 25,000 25,000 1 Malaysia Use for majoring gas products flow rate online. Quantify the gases product from reactor All users in the lab. 325 days per year375,000 300,000 75,000 375,00018 Dr Hendrik SimonCornelis MetselaarThermal and melting heattransfer characteristics in alatent heat storage systemof Phase Change Material(PCM) as an energy storage1 Thermogravimetric Analyzer 341,400 341,400 - 341,400 1 Germany/USA/S The Thermogravimetric Analyzer (TGA) is an essential laboratory tool used for material characterization. TGA is used as a Measures the amount and rate of change in the weight of a material as a function ofweeden technique to characterize materials used in various environmental, food, pharmaceutical, and petrochemical applications. A temperature or time in a controlled atmosphere. This equipment can help to publish 5 Tier 1TGA consists of a sample pan that is supported by a precision balance. That pan resides in a furnace and is heated or cooled ISI journal papers. Here is some list of tier 1 ISI journal for publication. 1st Renewable &during the experiment. The mass of the sample is monitored during the experiment. A sample purge gas controls the sample sustainable energy review 2nd energy 3rd solar energy material and solar cell 4th Appliedenvironment. This gas may be inert or a reactive gas that flows over the sample and exits through an exhaust. PerkinElmer energy 5th International journal of heat transferoffers two types of TGAs, a top-loading TGA 4000 and a bottomloading or hangdown, Pyris 1 TGA. The TGA 4000 supports thesample pan above the balance via a “stem” support rod. The Pyris 1 TGA supports the sample pan via a “hangdown” below thebalance. Both styles take advantage of gravity to obtain very accurate and reproducible measurements. These instruments canquantify loss of water, loss of solvent, loss of plasticizer, decarboxylation, pyrolysis, oxidation, decomposition, weight % filler,amount ofmetallic catalytic residue remaining on carbon nanotubes, and weight % ash.All these quantifiable applications are usuallydone upon heating, but there are some experiments where information may be obtained upon cooling. Both the Pyris 1 TGAEnergy Efficiency laboratory (level2 Blok M)and the TGA 4000 are controlled by PerkinElmer’s proprietary thermal software, Pyris Software, and have autosampleraccessories for unattended operation2 FTIR Spectrometer 248,400 - 248,400 248,400 1 Germany/USA/S FT-IR stands for Fourier Transform InfraRed, the preferred method of infrared spectroscopy. In infrared spectroscopy, IR This machine use for characterize the spectrum of light sourcesweeden radiation is passed through a sample. Some of the infrared radiation is absorbed by the sample and some of it is passed It can also identify unknown materials and determine the quality or consistency of a samplethrough (transmitted). The resulting spectrum represents the molecularBesides, the amount of components in a mixture can be determined by this machineabsorption and transmission,creating a molecular fingerprint of the sample. Like a fingerprint no two unique molecular The qualitative analysis of every different kind of material will identify. In addition, the size ofstructures produce the same infrared spectrum. This makes infrared spectroscopy useful for several types of analysis.the peaks in the spectrum is a direct indication of the amount of material present. Withmodern software algorithms,infrared is an excellent tool for quantitative analysis. This equipment can help to publish 5 Tier1 ISI journal papers. Here is some list of tier 1 ISI journal for publication. 1st Renewable &sustainable energy review 2nd energy 3rd solar energy material and solar cell 4th Appliedenergy 5th International journal of heat transfer.Potential users typically involve reseachers doing Heavy used (5 days weekly). each use will take about 30 minengine testing. At least 4 PhD and 2 MSc postgraduate to a few hours.students will be trained using this instrument.Potential users typically involve reseachers doing Heavy used (5 days weekly). Each test will take about up toengine testing. At least 4 PhD and 2 MSc postgraduate few hours.students will be trained using this instrument.589,800 341,400 248,400 589,800Hydrogen Refueling Station19 Dr Mahidzal Dahari 1 Supply Storage System 80,000 40,000 40,000 80,000 1 Malaysia Store hydrogen gasand Dispenser ControlSystems2 Dispensing System 40,000 20,000 20,000 40,000 1 Malaysia Deliver hydrogen gas3 Car Storage System 40,000 20,000 20,000 40,000 1 Malaysia Test and process hydrogen gas4 Recycling and Make-up40,000 20,000 20,000 40,000 1 Malaysia Recycle hydrogen gasSystem5 Data Acquisition System 40,000 20,000 20,000 40,000 1 Malaysia Collect experimental data6 Computer Control System 40,000 20,000 20,000 40,000 1 Malaysia Monitor and control hydrogen process7 Test-Rig Instrumentation60,000 30,000 30,000 60,000 1 Malaysia Other components (valves, fittings, piping) for completing fabricationSystem8 Fuel-Reforming System 60,000 30,000 30,000 60,000 1 Malaysia Produce and develop hydrogen gas9 Compressor System 40,000 20,000 20,000 40,000 1 Malaysia Compress hydrogen gas to higher pressure10 Flow-metering System 40,000 20,000 20,000 40,000 1 Malaysia Measure flowrate of hydrogen gasSince the development of a hydrogen refueling infrastructure is a critical element to theintroduction of fuel cell-powered vehicles, a flexible and low-cost hydrogen refueling test rigusing solar powered is proposed. It is flexible due to its ability to accept hydrogen from thethree available methods and easily be adapted to future renewable hydrogen productionsystem. The design is expected to be scalable for accommodating future growth which couldbe easily integrated to liquid hydrogen refueling with few modifications and minimalLab space is available in faculty of engineering (CADCAM department).additional investment. Along with all the built-in benefits of the station, innovative standardsand public awareness campaign are planned to encourage the acceptance of hydrogen as afuel, whilst supporting the national ongoing fuel cell-powered vehicle development program.With the operation of this facility to begin in 2011, it will be the first step in developing thecommercial hydrogen infrastructure of tomorrow, here in University Malaya.The research equipment is targeted to all level of The intensity and frequency of this equipment would be aresearchers in the world especially working on continuous usage for all researchers since thehydrogen economy since it covers a wide area of commercialization of gaseous hydrogen fueled vehiclesmultidisciplinary research fields. The contributions requires both the development of hydrogen fueled vehiclesfrom this research are expected to diversity into and the establishment of a hydrogen fueling infrastructure.following applications and technology areas;These requirements would create a circular cause and1) Hydrogen Fuel Reforming (efficiency study, consequence, that manufacturers will not build andturndown, compressor/purifier interface)consumers will not buy vehicles without an adequate2) Hydrogen Refueling Characterization (refining refueling infrastructure, whilst potential refueling stationthermodynamic model, refueling algorithm)operators will not invest the needed capital without an3) Hydrogen Dispensing Mechanism (component adequate market to serve. Therefore, the aims of this researchavailability & cost)are to achieve a hydrogen refueling system that wouldHydrogen Compressor (analytical design, tribology & breakthrough market requirements for cost-effectiveness,materials, empirical testing)reliability, and durability. It could discuss the fundamental4) Hydrogen Purification (assess adsorbent, membrane issues in term of energy consumption for producing hydrogenpurification strategies)based on renewable energy which subject to cost5) Hydrogen Station Design and Economics (system & expenditure, design analysis, safety, environmental issues,subsystem design and model, cascade storage and standards and public awareness. The approaches ofintegration system controls, economic model) developing the hydrogen refueling test rig could beAt least 5 PhD and 10 MSc students will be trained per elaborated into three main issues: how to mathematicallyPI from this project. This research will enable UM to develop and store the hydrogen gas, what testing facility iscreate niche area in hydrogen technology, which is needed to conduct the series of high pressure experiments;currently the latest technology is only available in US, and how to extract useful information for comparisons andEurope and Japan. UM hydrogen refueling test rig will verification of energy consumption.be the only state-of-the-art facility available to servefor ASIA countries (please refer to this website i.e.,www.fuelcellsworks.com)20 Dr. Andri Andriyana 1 Video Extensometer c/wAccessoriesTotal480,000 240,000 240,000 480,00090,000 - 90,000 190,000 - 90,0007,849,071 5,372,171 2,656,900 8,029,071 88Approved at the VM LABApproved at VM Lab-updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF SCIENCE)No PI's Name Project Title EquipmentEstimated budgetYear 2&3(2012-2013)2012(RM)Approved Budget(After VM Lab)2013(RM)Total(RM)Quantity/UnitOriginCountry ofDetails Justification of purchaseAdditional information(space/utilities eg electric, software etc)Potential users/research groups1Prof Dr. Harith Ahmad, HIR 1 - Femtosecond laser- Prof. Dr Richard M.De La and terahertz generationRue (Academic Icon), for photonics application- Prof. Dr Sulaiman WadiHarun,- Assoc. Prof. Dr Raymond Oii,- Dr Rozalina Zakaria,- Dr. Chong Wu Yi,- Mohd Zamani Zulkifli1 High resolution opticalmeasurement system2 Optical linewidthmeasurement system350,000.00 350,000.00 - 350,000.00 1 France/Japan High resolution measurement of narrow spectral width laser Current spectrum analyzers in the facility are sufficient for standard research Table top machine with a typical size of 50 cm x 50 cm x 30 Photonics Research Groups in Malaysia, namelysource.works (resolution = 0.05nm) but cannot resolve narrow spectral width laser, cm. Utilize single phase 240V/50Hz power supply. Comes with MMU. UPM, UniMAP etcwhich is one of the niche research trend. A high resolution opticalintegrated software. This machine is useful for Photonicsmeasurement system (resolution

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF SCIENCE)No PI's Name Project Title EquipmentEstimated budgetYear 2&3(2012-2013)2012(RM)Approved Budget(After VM Lab)2013(RM)Total(RM)Quantity/UnitOriginCountry ofDetails Justification of purchaseAdditional information(space/utilities eg electric, software etc)Potential users/research groups3Prof Dr. Yatimah Alias, HIR 4 - Molecular devices- Prof Dr. Hapipah Mohd Ali, for nanoscale applications- Prof Dr. Zanariah Abdullah,- Assoc. Prof Wan JeffreyBasirun,- Dr Sharifah Mohammad, DrIrene Ling1 Fluorescent probe 20,000.00 20,000.00 - 20,000.00 1 UK Portable flourescent testing probe is to measure chromophorecompounds whichapply in optical sensor2 Low melting point 100,000.00 100,000.00 - 100,000.00 1 Switzerland It is use to measuresample such as ionic liquids that have aanalyzermelting point below roomtemperature3 Microwave synthesiszer 150,000.00 150,000.00 - 150,000.00 1 Australia/ This instrument will be used to synthesise theGerman heterocycliccompoundsThis portable fluorescent probe is provided with xenon and tungsten This portable piece of instrument is easily to be transportedhalogen lamp that can give the fluorescence and UV-Vis signalsamong two research places, e.g. MIMOS-Chem. Dept., UM.synchronically and make easier in the measurement of chromophore For the testing purpose.activity.The low melting point analyzer is not available in UM.Microwave synthesis system is a high performance microwave instrumentfor theparallel synthesis of valuable compounds from reactionscreening tomultigram scale. A variety of rotors make this multimode reactoran effectivetool for process development and basic research in academiclaboratories.270,000.00 270,000.00 -270,000.00Prof. Dr Kam Toh Seok, HIR 5 - Bioorganic and4 1 Centrifugal Partition380,000.00 380,000.00 - 380,000.00 1 France The CPC system to be acquired is for carrying out larger scale CPC (and HSCCC) are among the latest additions to the armoury ofSpace available in existing instrument room; no special- Assoc. Prof. Dr Noel F. Medicinal Chemistry andChromatography (CPC)fractionation of extracts and fractions based on solvent separation technologies available to the separation chemist. Required for electrical requirements.Thomas,Organic Synthesispartitioning (separation based on polarity differences, pka's, rapid and efficient fractionation of complex mixtures (up to gram levels) as- Prof. Dr Noorsaadah Abd.relative solubilities, etc.).well as the method of final resort when all other alternative methods fail toRahman,work for a particular separation problem. A different approach from- Dr Choo Yeun Mun, Low Yunconventional adsorption chromatography, with the advantage of fullYee,material recovery, no solid stationary phases or columns, and minimum- Prof. Dr. Noorlidahsolvent use. Will increase efficiency and speed, as well as allow for higherAbdullah,throughput. To date no such system exists in the country. (Publications:- Dr. Annie Tan Geok Yuan,Organic Letters, J. Natural Products, Phytochemistry, Tetrahedron, J. Organic- Dr. Sugumaran Manickam,Chemistry, Organic and Biomolecular Chemistry, Chemistry - An Asian- Dr. Yong Kien Thai,Journal)None in 2 Fluorescence Microplate70,000.00 70,000.00 - 70,000.00 1 USA For detecting/reading fluorescence and absorbance generatedDepartment; required in work on microbial cultures and microbial- Dr. Lim Kuan HonReaderfrom microbial growth and activityactivity(Nottingham)3 Ultra Low Temp. Fridge 60,000.00 60,000.00 - 60,000.00 1 USA For long term storage of pure compounds withoutNone in laboratory; require a single decicated unit in Lab for long termdecomposition or degradationstorage of pure compounds4 Autoclave 30,000.00 30,000.00 - 30,000.00 1 USA For sterilization of samples and other equipment None in laboratory and impractical to share; require a single decicated unitin Lab for daily sterilization of samples and equipment5 CO 2 Incubator 20,000.00 20,000.00 - 20,000.00 1 USA For storage and handling of cell lines None in Lab and Department; needed for storage and manipulation of celllines6 Liquid Nitrogen Cryogenic30,000.00 30,000.00 - 30,000.00 1 USA For long term preservation and storage of cell lines and None in laboratory; needed for preservation of cell lines and microbialTankmicrobial culturescultures7 Vacuum Oven 25,000.00 25,000.00 - 25,000.00 1 USA For evaporation of solvents and water None in Lab; needed for routine (daily) drying of pure compounds, fractions,and other samples8 Low Temp. Reactor 40,000.00 40,000.00 - 40,000.00 1 Japan For conducting low temperature reactions None in lab and Department; needed for carrying out reactions at lowtemperatures9 Rotary Evaporators 50,000.00 50,000.00 - 50,000.00 2 Germany For evaporation of solvents Required for replacement of old units and for increased capacity in theevaporation of solvents from extracts and fractions10 Concentrator 140,000.00 - 140,000.00 140,000.00 1 USA For high volume, high throughput, concentration of extracts, At present only a low capacity version and one limited to non-aggressive Space available in existing instrument room; no specialsolutions, and chromatographic fractions containing a wide solvent application is availableelectrical requirementsspectrum of solvent types.For use in mobile phases in 11 Ultrapure Water Unit 25,000.00 - 25,000.00 25,000.00 1HPLC, and for preparation of buffers None in Lab and Department; required for preparation of solvents for HPLC,Germanyand media for cell culturesbuffers, media, etc.None in Lab and impractical 12 Thermal Cycler (for PCR) 30,000.00 - 30,000.00 30,000.00 1For carrying out polymerase chain reactions in molecularto share; need a dedicated unit in Lab to copeUSAbiology experimentswith ongoing and continuous experiments900,000.00 705,000.00 195,000.00900,000.00Potential users: organic chemists requiringseparation based on polarity differences, pka's,relative solubilities, etc.5Prof Datin Dr. Saadah AbdulRahman,- Prof Dr. Wan Haliza Abd.Majid,- Assoc Prof Dr. Siti MeriamAb. Gani,- Dr. Ahmad Shuhaimi AbuBakar,- Dr. Zarina Aspanut,- Dr. Woon Kai Lin,- Dr. Huang Nay Ming,- Dr. Vengadesh A/LPeriasamy, Prof Dato’ Dr.Muhamad Rasat Muhamad,HIR 6 - Synthesis andApplication of LowDimensional Materials1 Gas Purification and SupplySystem200,000.00 200,000.00 - 200,000.00 1 Japan / UK / 1) To supply and purify bulk gas sources from gas cylinders toGermany high purity gases before entering MOCVD reactor.Gas supply system include gas manifold, gas cylinder cabinet,gas control panel, gas purging system and gas piping line fromgas cylinder cabinet to gas purifier inlet.The gas purification system consists of in-line gas purifier toremove impurities from the supplied gas. Room-temperatureresin type gas filter is proposed for the system, which purifieseach of the hydrogen (H2), nitrogen (N2) and ammonia (NH3)gas before being supplied to MOCVD inlet.The gas supply system and gas purification system are mandatory facility for Mandatory facility for MOCVD system.Potential users include researchers from UM,MOCVD system in 2011 budgetary.MOCVD system cannot run without this equipment.USM, UiTM, UTHM and others.No similar system is available in UM.The gas supply system includes cylinder cabinet, gas leak sensor and double The MOCVD system attached to this equipment can also becore piping for human safety during any leakage of silane (SiH4) and used by other researchers related to III-V research.ammonia (NH3) gas.Room/floor space is already allocated by the department.A class 1000 / ISO 6 clean room is necessary for MOCVD andThe purification system purifies bulk nitrogen (N2), hydrogen (H2) and gas purification system.ammonia (NH3) from gas cylinders to more than 8N (99.9999999) purity Without this equipment, MOCVD system cannot be run and IIIbeforeentering MOCVD reactor. High-purity gases are mandatory for highqualitycrystal growth by MOCVD.V research cannot be performed in UM.Results from this equipment can be publised on Tier 1 journals such asApplied Physics Letter, Journal of Applied Physics, Nature, etc.2 Electroluminescence (EL)System498,200.00 498,200.00 - 498,200.00 1 Japan / USA 2) To measure optical characteristics of optoelectronic devices, The electroluminescence (EL) measurement system is essential to measure Necessary to measure characteristics of optoelectronic Potential users include researchers from UM,including LED, OLED and LD.characteristics of light emission spectrum and properties of color rendering devices including LED, OLED and LD.USM, UiTM, UTHM and others.index (CRI) of light-emitting diode (LED), organic light-emitting diode (OLED) Equipment compatible with GaN-based LED wavelengthElectroluminescence (EL) measurement system measures and laser diode (LD) to be fabricated in this project.range from 200 nm to 2000 nm is not available in UM.photonic emission of an active layer in any light emission deviceThe equipment can also be used by other researchers workingwhen current is applied to the device.Results from this equipment can be publised on Tier 1 journals such as with light emission devices.Applied Physics Letter, Journal of Applied Physics, Nature, etc.Measurement result from EL is required to prove LEDperformance which is necessary for Tier 1 journals.Software is included.Room/floor space is ready/available.3 Semiconductor ParameterAnalyzer4 Photolithography (Mask-Aligner) System200,000.00 200,000.00 - 200,000.00 1 USA 3) To measure electrical characteristics of electronic andoptoelectronic devices, including LED, LD, PD, SC and HEMT.The proposed system is a precision semiconductor parameteranalyzer with digital sweep parameter control and powerfulfailure analysis tools.500,000.00 - 500,000.00 500,000.00 1 Germany / 4) To perform photolithography process for fabrication ofKorea optoelectronic and electronic devices.Photolithography mask aligner is used in microfabrication ofelectronic and optoelectronic devices in research laboratoriesand in even in low-volume production facilities. Almost anymicroscale device or structure requires more than onephotomask step. The mask-aligner allows its user to alignfeatures on a substrate (wafer) sample to features on aphotomask. The production of sophisticated electronic devicesmay involve ten or more of these alignment steps.1,398,200.00 898,200.00 500,000.001,398,200.00The system is able to perform all general electrical characterizations such as Necessary to measure electrical characteristics of HEMT, LED, Potential users include researchers from UM,current-voltage (I-V), capacitance-voltage (C-V), pulse generation, fast I-V, OLED, PD, SC, LD, etc.USM, UiTM, UTHM and others.and time domain measurement of electronic devices.No similar equipment is available in UM. Researchers inElectrical Engineering UM also interested to use thisResults from this equipment can be publised on Tier 1 journals such as equipment for their research, and the equipment will beApplied Physics Letter, Journal of Applied Physics, Nature, etc.opened to others.Without this equipment, it would be difficult to performadvance electrical measurements to fabricated devices andwould be hard to publish in Tier 1 journals.Software is included.Room/floor space is ready/available.The proposed system have nano-imprint capability which is not available in Mandatory equipment for LED, LD, PD, HEMT, etc device Potential users include researchers from UM,general photolithography system. Nano-imprint is necessary to improve fabrications.USM, UiTM, UTHM and others.light extraction efficiency (LEE) of light emitting diode (LED). Photonic The proposed equipment can also be used to produce nanoimprint/ nano-lithography on sample/substrate surface tocrystals (PC) can also be fabricated using the nano-imprint photolithographysystem.improve LED light emission performance.Equipment with nano-imprint capability is not available inResults from this equipment can be publised on Tier 1 journals such as UM. Readily available equipment at other laboratory is noApplied Physics Letter, Journal of Applied Physics, Nature, etc.longer usable and not upgradable for nano-imprint / nanolithography.Room/floor space is ready/available.A yellow room with class 1000 / ISO 6 clean room is necessaryfor this equipment.- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF SCIENCE)No PI's Name Project Title EquipmentEstimated budgetYear 2&3(2012-2013)2012(RM)Approved Budget(After VM Lab)2013(RM)Total(RM)Quantity/UnitOriginCountry ofDetails Justification of purchaseAdditional information(space/utilities eg electric, software etc)Potential users/research groups6Assoc Prof Dr. Koshy PhilipHIR 8 - Mechanism ofbinding of antimicrobialpeptides on targetedbacterial membrane (andits effect on host tissues)1 Visible spectrophotometer 27,000.00 27,000.00 - 27,000.00 1U.S.A.(1) For bacterial culture work - growth curve 1) To develop growth curves of the bacterial cultures used in the study, 1) Self calibration available for the instrumentassays of the antimicrobial compounds 2) Cannot do without the instrument2) Bioassay of antimicrobial compounds 3) Similar instruments are being used intensively by other projects and 2) Model: Genesis Thermo Scientific3) Microbial enzymatic assays researchers 4) Checked that it is available 5) Question of upgrading does not 3) 190 nm - 1100 nm wavelength4) Kinetic growth curve arise as this is an instrument that cannot be upgraded 6) Other researchers 4) Xenon lightassociated with me such as those working on biofuel can also use it 7)Additional bench space can be created for the instrument 8) A market checkwas done before arriving at the price 9) this particular model can fulfil theresearch requirments 10) I do not wish to mention any sole agent 11)Similar equipments available in UM are of older specifications, a reliable onewith updated specifications can provide better quality data for the researchproject as it is critical to publishing tier one papers 12) Maintenance isminimal, calibration can be done by the principal investigator throughregular checks 13) The equipment does not need any software upgrades 14)Hardly any installation or maintenance costs 15) The research project can bedelayed especially with several new post graduate students planned forenrolment in the year 2012 16) Without this equipment, it will be verydifficult to publish in tier one journals 17) It will be used on several times aday - can be used on any microbiology or biotechnology project.27,000.00 27,000.00 -27,000.007Prof Datuk Dr. A.HamidA.HadiHIR 9 - Bioactivecompounds FromMalaysian Plants1 NMR 500MHz with2,500,000.00 2,500,000.00 - 2,500,000.00 1 Japan 500 MHz NMR machine is used to:The 400 MHz NMR machines which belong to the department are heavily This 500 MHz Instrument occupies only small space and themicroprobeused : 1. 90 registered NMR usersdepartment can provided space for this machine. TheIdentified the structure of phytochemicals isolated from plant 2. 35% of users from the Natural products groupelectrical power is needed to run the machine.species. This machine will measure :3. 30 unregistered users per year including the Chemistry Department andfinal year students2 HPLC preparative 600,000.00 - 600,000.00 600,000.00 1 Japan/ This machine is used to separate the enantiomeric compounds This machine is needed for separating the enantiomeric isomers. Without This machine does not require big space. It can be put in theUSA isolated from the plant species. The enantiomeric mixture can this machine, it is difficult to separate the minor component and also the laboratorynot be separated by normal chromatographyical technique. This mixture of enantiomer. Without this machine, it is difficult to publish in tierisvery important intrument especially to identified whether the 1 journal.molecul has R or S configuration and it helps to publish paper intier -1 journal.3 High resolution LC-MS 2,000,000.00 2,000,000.00 - 2,000,000.00 1 Japan/ USA This machine is used for measuring the relatif mass of themolecules. The higest resolution mass is needed for tier-1publications.This instrument will be used to separate every compound present in theextract of the plant species and it also will measure the mass of themolecule at the same time. This will speedup the isolation process and theidentification of the compounds.This machine does not require big space. It can be put in thelaboratory4 Flow cytometer 600,000.00 600,000.00 - 600,000.00 1 USA This machine is used for measuring the cyctotoxicity activity of This machine is needed for the study of mechanism of anticancer activity.the crude and isolated compounds. It is very useful in the study Without mechanism, it is difficult to publish in tier -1 journal. This machineof the cytotoxicity mechanism. With the mechanism, paper can will be used by the natural product group.be published in tier-1 journal.This instrument will be placed in the department ofpharmacy. The department will provide the space for thisinstrument5 Preparative GC 500,000.00 500,000.00 - 500,000.00 1 Japan/ USA Preparative GC is very important instument in the field of This instrument is needed for the isolation of minor volatile compounds. So This instrument can be placed in the department and it needessential oil. The plants also produce essential oil which have far this type of compounds can not be isolated. A lot of new compounds a small space.many commercial appication such as food flavour, fragrant and present in small quantity. This mechine is not available in this university.insect repellent. This instrument is used separate the volatile With this machine, we can isolated the minor compounds and identified thecompounds and at the same time it will give the structure of the structure via spectroscopic technique.compounds. This instrument can help this project to publishpaper in tier-1 journal especially in journal of food and essentialoil.6 GC-MS TOP 1,000,000.00 1,000,000.00 - 1,000,000.00 1 Japan/ USA GC-Mass TOF is used to recognise the mass with special RT This instrument is needed for getting the exact mass of the compound in the This intrument can be placed in the department and it needspeak. Every peak will be identified using mass spectroscopy. It gas phase. We can study the fragmentation pattern of the parent molecule. only small space.helps to publish paper in tier-1 journal.With this data alone we can publish in tier-1 journal.7,200,000.00 6,600,000.00 600,000.007,200,000.008Prof Dr. Kwek Kuan HiangHIR 10 - High EnergyDensity Physics1 Oscilloscopes 130,000.00 - - - 1 USA 1) To capture transient X-ray, current, voltage and laser signals. The 1 GHz analog bandwidth oscilloscopes are necessary because thesignals are all of picosecond risetimes. Two units are required to provideeight channels.2 High vacuum system 31,050.00 - - - 1 UK 2) To establish a vacuum environment of less than 1e-5 torr inthe load chamber for wire ablation experiments.To obtain very low vacuum conditionProject Drop3 Pulse generators 20,000.00 - - - 1 USA 3) To generate low voltage pulses for the synchronization of the To synchronize electronic contral and x-ray systemelectronics that control the laser system, the x-ray imagingsystem and the high voltage generator.181,050.00 - - -- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF SCIENCE)No PI's Name Project Title EquipmentEstimated budgetYear 2&3(2012-2013)2012(RM)Approved Budget(After VM Lab)2013(RM)Total(RM)Quantity/UnitOriginCountry ofDetails Justification of purchaseAdditional information(space/utilities eg electric, software etc)Potential users/research groups9 Prof Dr. Rauzah Hashim,- Assoc Prof Dr. ThorstenHeidelberg,- Rusnah Syahilah DualiHussen ,- Nasrul Zamani Mohd Rodzi ,- A. Sugimura (Osaka SangyoUni),- H. Naito (Osaka PerfectureUniversity),- Osama Abou Zeid (SultanQaboos University)10 Prof. Dr Edward R.T. Tiekink,Prof. Dr Ng Seik Weng, Assoc.Prof. Lo, KM, Dr N. Halim, DrTan Kong WaiHIR 11 - Understanding 1 Photon correlation250,000.00 250,000.00 - 250,000.00 1 UK determination of particle size and size distribution (range ~ 1 The determination of particles sizes and size distribution is an essential stand alone benchtop system with standard 2-phase electricGuerbet glycosides selfassemblystructures andparticle sized between 5 nm and 10 mmcritical for potential applications. The zeta-potential enables a prediction on space (~80 cm bench, < 30 kg) for placement in M008bspectroscopynm to 5 mm diameter); Zeta-potential measurements for feature in the formulation studies for vesicles, as these parameters are supply (80 W/220V) and no special room requirements; labdynamics for functionalthe stability for dispersions and emulsions and, therefore, is an important available; no special maintenance of equipment and nonano-biotechnologyfeature for formulation designs as well. The optimization of formulations updating of software or databases required; repairs requirerequires accessibility of the analytical instrument. Although an instrument authorized engineerwith required feaures is available in UM, the machine is heavily utilized andaccess is limited to one paticular day in the week.These restrictions preventan effective fromulation study and, thus, affect the progress of the research.250,000.00 250,000.00- 250,000.00HIR 12 - NanoCav 1 Modular spectophotometer 194,685.00 194,685.00 - 194,685.00 1 USA/Japan This attachment is designed to enable the measurement of There is no equipment in UM to perform this function. This equipment will At present UM does not have this capability. However, oncevariable temperature solid-state responses of particular interest allow efficient screening of synthetic compounds for their solid-state the instrument has been installed and is operational, it isto this gold but, also to the metal-organic framework project photoluminescence characteristics that can be correlated with their crystal hoped that chemists working in all chemistry disciplines will(HIR/SC/03). At present we obtain such data from collaborators structures. Our previous experience has shown that the addition of these avail themselves of this spectroscopic opportuntity. Ideally,from around the world but for high-throughput in-house data to our research projects enables publication in high-impact Journals this modular attachment can be added on to a pre-existinganalysis, effective and vital spectroscpic data may be collected such as CrystEngComm and Crystal Growth & Design. Other targetted highimpactJournals for our research output in Dalton Transactions, Chemistry of should be no special space requirements for the newspectrophotometer and removed, as necessary. Thus, therein a timely fashion.Materials, Journal of Materials Chemistry and Chemical Communications. equipment.In summary, a key component of both Tiekink's HIR3 and HIR12 projects isthe measurement of variable temperature solid-state luminescence data toenable higher-quality publications.194,685.00 194,685.00 -194,685.0011 Prof Dr. Kurunathan HIR 13 - Network Analysis 1 SGI Altix UV100-XE: HighRatnaveluof Social, TechnologicalPerformance Computerand Biological Networks(HPC) [Integrated Compute,Storage & GPGPUAccelerated System: 4 x 6-core Intel Xeon 2.66GHzprocessor, 32 x 2GB DDR3system memory, 4 x 3TB7200RPM SATA storage, 1 xNVIDIA M2090 Tesla GPU,1 x NVIDIA QUADRO 6000GPU]249,991.00 249,991.00 - 249,991.00 1 USA 1. Development of massively parallelized graph layoutalgorithms by utilizing a GPGPU (General Purpose GraphicsProcessing Unit) implementation of the Barnes-Hut n-bodysimulation algorithm.2. Development of GPGPU Monte Carlo algorithms for largenetwork dynamics (time evolution) simulations.Fast (large) network layout algorithms and Monte Carlo network evolution Requires constant air-conditioned environment and UPSsimulations scheduled for development under this project require hardware (Uninterrupted Power Supply) system. This system takes up a(GPGPU) acceleration using the CUDA (Compute Unified Devicesmall footprint (uses 3U chasis: D650 X W483 X 133H mm).Architecture) and OpenCL (Open Compute Language) framework. CUDA andOpenCL enable direct interface to the 512 compute cores on the NVIDIATesla M2090 GPU to deliver a peak performance of up to 600 gigaflops (600billion floating point operations per second) in double-precision. In contrast,a quad-core Xeon X5365 processor delivers only 38 billion flops (under theLINPACK benchmark). An equivalent GPU-accelerated SMP (SymmetricMultiprocessing) HPC is not available in UM.2 Other peripherals 40,000.00 25,000.00 15,000.00 40,000.00 1 Provisioned for procurement of additional 2 units of NVIDIATesla M2090 cards.289,991.00 274,991.00 15,000.00289,991.0012,121,526.00 10,334,676.00 1,605,800.00 11,940,476.00 Total 39To develop scalable multi-GPU (GPU-cluster) network layout/Monte Carlocodes.No additional hardware requirement - the Altix UV 100-XEcan host another two (2) GPUs. Codes developed for single-GPU runs will be modified to work on multiple GPUs.- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF DENTISTRY)Approved Budget(After VM Lab)No PI's Name Project Title EquipmentEstimatedbudgetYear 2&3(2012-2013)Quantity/unitCountry oforiginDetailsJustification ofpurchaseAdditional information(space/utilities eg electric, softwareetc)Potential users/research groupsFrequency andintensity of usage2012(RM)2013(RM)Total(RM)1 Prof. Dr. Rosnah Mohd. Zain;Biobanking of oral cancers: An1 Enhancement of415,000 415,000 - 415,000 1 Malaysia The system to be procured is an 1) Limited capacity of the existing database: With theSpace available at the new post-Currently 3 HIR and 5 UMRG projectsFor database, usageCo-PI: Prof. Dr. Zainal Ariffassessment of survival,databaseentry level set-up which willexpanding data, we need to enhance our databasegraduate building, Fac of Dentistry.are using the data and specimen fromdepends on request fromAbdul Rahmanclinicopathological parameters,management strategies, nutrition andgenetic susceptibility of patientsconsist of servers for data and biobank system to cope with the huge amount of Workstation, hardware and softwarestorage and processing, highendworkstations, applicationdata collected over the years. Furthermore, in the included.future, we also plan to include and link all researchNeeds air-conditioned room for serverfindings such as genetic and 'omics' data.software, storage managementwhich is available.In2) No integration of softwares/ programs: Currently,solutions and databases that willthe future, it is planned that geneticthere are few programs/ softwares that was purchasedbe used as a platform to supportor developed in-house for data, specimen and image(transcriptome, 'omics') data fromand integrate existing standaloneapplication programs, efficient data and image retrieval.will be added to database.storage. These programs needs to be integrated for research findings (profiling, NGS etc)databases and low-end3) Lack of appropriate infrastructure: Currently, the Previously this database/biobank hashardware.The system will also oral cancer database is installed and kept on a low-been utilised by 8 projects (E-Science,the biobank/database. Another 2 HIR various projects/reseachers/projects pending approval from KPT is postgrads on weekly basis.also planned to utilise the resources For the specimen/biobank,from the biobank/database. Eventually usage almost on daily basis,the proposed enhancement of database either in terms of specimenwill enable all researchers including requests, process andpostgraduates, scientists from various storage.groups to extract relevant/requireddata/specimen. The credibility of thisdatabase/biobank system has beeninclude data recovery andend laptop and the data is backed up on CDs andUMRG, IRPA) where more than 35recognised where internationalbackup components. In addition, thumbdrives. We need a high-end and high capacitypapers has been published.collaborators has also utilised ourappropriate networking systemwill also be made available forefficient data entry and retrievalwithin a client/serverarchitecture.data storage facility (ie. servers) to house and securethe voluminous data. We also need appropriate serverto back up the valuable and critical data. As the dataincreases, we also need high end workstations so thathuge data and images can be uploaded and retreivedmore efficiently.data/specimen.2 Prof. Dr. Zainal Ariff AbdulConstructing the cancer progression1 License for20,000 - - 0 10,000/ per year Sweeden License for software for Systems This software is required for the analysis of theThis software will be installed in anThis software will be primarily used byThe software will be usedRahman ; Co-PI:Prof. Dr.model: The identification of key playerssoftware forBiology analysis (PathwayLab,different pathways involved in cancer progression. In existing computer and no additionalour team to analyse the cross talkextensively after theCheong Sok Chingin malignant transformationSystems BiologyInNetics Sweeden).particular, it will help with the analysis of crosstalkspace or utilities are neededbetween the epithelial cells and themicroarray experiments areanalysis(PathwayLab,InNeticsbetween epithelial compartment and the tumourmicroenvironment.tumour microenvironment. However, the completed. The software willsoftware will be useful for anybe used extansively againresearcher who is working on systems during the validation stageSweeden).biology.when we identify additionalpathways that could beperturb by specific genesthat control malignanttransformation.435,000 415,000 0 415,000 2Rejected after VM Lab- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF COMPUTER SCIENCE AND INFORMATION TECHNOLOGY)NoPI's NameProject TitleEquipmentEstimated budgetYear 2 & 3(2012 & 2013 )2012(RM)Approved Budget(After VM Lab)2013(RM)Total(RM)Quantity/unitCountry oforiginDetailsJustification ofpurchase1 Dr MohammedZiaur RahmanRecursive Approach for theDesign of AsynchronousSequential Circuits1 Synopsys License(5 Nos for 5 years)241,350 112,000 129,350 241,350 1 USA The full contents of the front and back end bundles are:Synopsys VCS &VCS-MXSynopsys Design Compiler UltraSynopsys DFT CompilerSynopsys Power CompilerSynopsys DesignWareSynopsys (V)HDL CompilerSynopsys TetraMaxSynopsys PrimeTime SuiteSynopsys FormalitySynopsys Nanosim & PrimeRailSynopsys IC ValidatorSynopsys Hercules& Star RCSynopsys IC Compiler (Full suite)Synposys Full Custom BundleSynopsys HSPICESynopsys Custom ExplorerSynopsys Custom WaveViewSynopsys ChipViewSynopsys Custom Designer SESynopsys Custom Designer LESynopsys CustomSimSynopsys Custom Designer SDLSynopsys Cosmos Scope241,350 112,000 129,350241,350The front end is required for capturing and designing the logiccircuit and entering the full schematic information. It covers logicaland functional design of the circuit, verification, analysis andsynthesis of the prototype design. The back-end is required forphysical prototyping. It includes physical layout options, place androute options, design rule check options, extraction and timinganalysis facilities and generation of GDS file for actual fabrication.The custom bundle is required to design non-conventional (nonstandard cell based designs) and fully custom circuits for functionalevaluation, analysis, synthesis and testing. As the current researchobjective is to design an asynchronous processor it needs to havethe custom design flexibilities. This will enable the researchers todesign clock-less asynchronous control systems for use with thelogical design by front-end bundle.2 Prof. MadyaDr. AbdullahGhaniMobile Cloud Computing:Device and Connectivity1 Hardware for Cloud Infrastructure * -Additional Blade Server120,000 120,000 - 120,000 10 Malaysia Propose hardware - Dell(TM) PowerEdge(TM) 2 Socket Half HeightM610 Blade ServerAdditional blade servers is used to enhance research output ondeveloping mobile cloud computing infrastructure2 Hardware for wireless Infrastructure- Blackberry smartphone- iPhone mobile - iPhone Tablet- Android-based Tablet- Base Station Subsystem- Wireless Access Point- Android-based mobile device100,000 100,000 - 100,000 10 - Android 3.2 Estimate price RM2k per unit- Base Station for WIMAX- Cisco Aironet 3500 Series- Require to support current WiFi technology- Latest version of Android Estimate price RM2k per unitMobile devices are required to produce real output from ourinvestigation and research. Emulators and simulators specially inmobile domain and Mobile cloud computing are not reliableenough to produce valuable and reliable data and consequentlyhigh impact publication cannot be made based on them. In part ofour group study we should investigate interoperability, portabilityand fragmentation of mobile applications while current emulatoraare unable to do so. Create a software development platform forMobile Cloud Computing and to create a testbed for applicationframework to study real impact of heterogeneity on code and datafragmentation in Mobile Cloud Computing.In order to produce realcontextoutcome from the project, there should beinhomogeneous products from major mobile manufacturers likeBlackberry, Apple and Android. Wireless connectivity is requiredto connect mobile devices together, since all mobile platforms areprohibiting direct connection with each other.3 Tools and Software- Aneka Cloud- vSphere VMWare45,000 45,000 - 45,0001Malaysia - Aneka and VMWare vsphere required to implement cloudcomputing on existing infrastructure.Required to virtualize cloud infrastructure and to deliver researchmethodology for cloud computing.265,000 265,000 -265,000- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (FACULTY OF COMPUTER SCIENCE AND INFORMATION TECHNOLOGY)NoPI's NameProject TitleEquipmentEstimated budgetYear 2 & 3(2012 & 2013 )2012(RM)Approved Budget(After VM Lab)2013(RM)Total(RM)Quantity/unitCountry oforiginDetailsJustification ofpurchase3Dr. Ng LiangShingA Generic / NaturalLanguage Expert Systemfor Robotics and BazaarSimulation1 Robots & Parts 58,500.00 19,500.00 39,000.00 58,500.00 1 Japan, China, Robots are required to test simulation, e.g. humanoid, wheeled,Korea, Europe, pedaled.USACameras - (DIGITAL CAMERA Olympus CREATOR - X series XZ-1)Personal computer - (NEW XPS 15z DELL LAPTOP)Robort & Robotic parts are required to add and test additionalfunctions of robots and test the simulationCameras are required for additional vision functions for robotsPersonal computer needed to control the robot and entire systemto make robort functionable2 Server 39,850.00 13,850.00 26,000.00 39,850.00 1 Japan, China, Server is used for simulation and computation of objects in simulation. Server is used for simulation and computation of objects inKorea, Europe, (ServMaxPSC-1i Tesla GPU HPC, CPU i5-2300, Kingston DDR3 simulationUSAPC1333MHz 2GB, Nvidia Tesla TPP GPU C2050)3 Simulation Software 13,500.00 4,500.00 9,000.00 13,500.00 1 Japan, China, Simulation software is required to test the theories proposed.Korea, Europe, (Webot)USASimulation software is required to test the theories proposed.(Webot)111,850.00 37,850.00 74,000.00111,850.004 Prof SitiSalwah SalimMultimodal engagementfor children withcommunication disabilities1 1. ProComp Infiniti - 8 ChannelBiofeedback & Neurofeedback System20,000 20,000 - 20,000 1 USAProComp 8 w/ Physiology SuiteEEG SuiteMyo Scan ProEKG SensorEKG Receiver for Polar BeltSkin Conductance Sensor SA9309MRespiration SensorsBlood Pulse Volume SensorTemperature SensorEEG-Z Sensor, with monopolar/bipolar kitBag of 100 Triode ElectrodesTen-20 Conductive EEG pasteNuprep EEG Skin Prep GelThe ProComp Infiniti is a new 8 channel, multi-modality encoderfor real-time, computerized biofeedback and data acquisition inany clinical setting. The device is helpful to capture the disabledchildren brain waves while he/she is asked to do a task orread/utter a sentence. The captured signal can later be used bycomputers in order to estimate the requested task or sentence.Furthermore, the captured brain signals can be useful for theresearchers and computers to understand the emotional state ofthe children while conducting the experiments. These emotionalstates may be applied to formulate an immediate interventionapproach for disabled children who suffer from speech disorders.The first two sensor channels provide ultimate signal fidelity (2048samples per second) for viewing RAW EEG, EMG and EKG signals.The remaining six channels (256 samples/sec) can be used withany combination of sensors, including EEG, EKG, RMS EMG, skinconductance, heart rate, blood volume pulse, respiration,goniometry, force, and voltage input.2. Torgo Dysarthric Speech DatabaseTorgo is a new database of dysarthric speech in terms of alignedacoustics and articulator data.The database will be analyzed to study the significant relationshipbetween speech errors and the different type in severity of speechdisorders to gain broader picture on speech error detection amongother languages and its similarity to Malay.20,000 20,000 -20,0005 Dr Effirul Natural Computation:Ikhwan Ramlan Molecular Computing1 Upgrade of computing peripherals 21,300 10,300 - 10,300 2 USA,distributed byIBM malaysiaofficeA high powered computing node –an additional part to be added to an existing cluster.Specs: HS22, Xeon 4C E5620 80W 2.40GHz/1066MHz/12MB, 3x2GB ofRAM– 2 Units –This is to add to the existing blade cluster of 14 units (existingfacility in Crystal, Faculty of Science, University Malaya). Thisupgrade is to increase the computation capability in simulating andestablishing a “real” context sensitive environment of physicochemicalself-assembly environment using parallel architecture. Inaddition, the two extra node will also lessen the processingcapacity currently undertaken by the existing cluster and will beplaced at Crystal Server Room, Faculty of Science, UniversityMalaya21,300 10,300 -10,300Total659,500.00 445,150.00 203,350.00 648,500.00 28- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (CHANCELLORY)No PI's Name Title Equipment1 Dr. Chan Kok Gan Bacteria QuorumQuenchingEstimated budgetYear 2 & 3(2012 & 2013 )Approved Budget (After VM Lab)2012 (RM) 2013 (RM) Total (RM)1 LCMS 450,000 450,000 - 450,000 1 USA LCMS is an analytical chemistry technique that is used todetermine the mass of a molecule and quantify trace levels ofsuch compound. LCMS is particularly useful to study knowncompounds.Quantity/unitCountry oforiginDetailsJustification ofpurchaseThis LCMS is needed by by my group which routinely study theproduction and degradation of bacterial cell-to-cell signallingmolecules. LCMS can determine the degraded compounds, withoutthis instrument, we will not be able to identify the moleculeturnover, and hinder the elucidation of encymatic degradationpathway by the bacteria. LCMS offers rapid and efficient detectionthat other methods (e.g. biosensor) cannot compete with.Additional information(space/utilities eg electric, software etc)Lab space is available in my lab.Molecule mass identification and database softwares areincluded. Without this instrument, it is impossible to doresearch on identification of degraded quorum sensingcompounds particularly those present in trace amount.Many work reported in reputable journals including J.Bacteriology, Environmnetal Microbiology, AppliedEnviromental Microbiology.Potential users/research groupsPotential users typically involve chemist,phytochemist, natural products scientists andpharmacist.At least 2 PhD and 10 MSc students will be trainedusing this instrument.Frequency and intensity of usageUse on daily basis (6 days per week, whole day), forroutine screening of quorum sensing and quorumquenching studies.2 MultimodeLuminometer180,000 180,000 - 180,000 1 USA/GermanyIt is a 96-well microplate luminometer with high sensitivity Since we have constructed our lux based biosensor that emits This is a small instrument and table-top size. Analysisand broad dynamic range for chemiluminescent and bioluminescence, or quorum sensing and quorum quenching and softwares are included. This instrument generates databioluminescent applications. It measures bioluminescence, natrual products projects rely heavily on this automatedthat can be published in Microbial Ecology, J.fluorescence, visible or UV-visible absorbance in 96 and 384- instrument. We also use this for high throughput drug discovery Bacteriology, BMC Microbiology, PLoS ONE.well plate formats.screening. Unlike other multimode systems, readings taken withthismultimode luminometer is not degraded by indirect fiber-optictransmission or crowded optical channels. Dedicated opticalchanneling ensures that this unit provides sensitivity and dynamicrange on par with the highest performing single-mode instruments.Target users including microbiologist or scientists Use on daily basis (6 days per week, whole day), forwho require automated detection and data routine screening of quorum sensing and naturalgeneration of bioluminescence, andproducts studies.cehmiluminosence work.At least 1 PhD or 5 MSc students will be trained perPI using this instrument.3 qPCR thermocycler 180,000 180,000 - 180,000 1 USA/Korea4 Rotary evaporator 40,000 40,000 - 40,000 1 USA/GermanyqPCR (polymerase chain reaction, PCR) is which data are A full operation of this instrument will run for 6 hr to 1 day. Our lab Lab space is available in my lab. This is a small instrument. Target users including bioinformaticians, systemcollected in real-time as the reaction proceeds. Continuous will use this for twice a day for 5 days per week. It is anticipated qPCR is the only method for DNA amplication in vitro. biologist, bacteriologist, virologits, moleculardata collection enables one of the principal applications of that this instrument will be heavily used by my group members Most Tier 1 journals such as PNAS, J. Bacteriology, BMC biologist, medical scientists that requires genesreal-time PCR, target quantitation. Because we are doing tens working on GWAS and genomic work.Genomics, PLoS ONE requires qPCR as the PCR method. expression quantitation.or hundreds of novel, de novo , bacteria genomes analysis,Nearly most molecular biology research requireshence quantitation or genes expression is the only way toqPCR for PhD and MSc students work.verify genes activity in a given genome. And qPCR is one suchinstrument that provides quatitation data.This is also become one of the routine facility in molecularbiology lab.A rotary evaporator is required for the efficient and gentle The natural products and quorum sensing projects typically requires No special electricity and software needed. This is a small Natural products and quorum sensing projectsremoval of solvents from samples by evaporation. This is a isolation and concentration of small molecules. This instrument instrument. Most Tier 1 journals such as J. Nat. Products, reserchers.modular system that comes with water bath, organic solvent provides rapid, non high heat drying of compounds which is an PLoS ONE requires this instrument as part of theresistant vacuum pump.cheaper alternative as compared to freeze dryer. Hence, this is a methodology.money worth, and essential item for the projects aforesaid.Use on daily basis (6 days per week, whole day), forGWAS, gene expression and quantitation, and wholegenome work.Frequently used by natural product groups (5 daysper week, 5-6 hr per run)5 Autoclave 18,000 18,000 - 18,000 1 Japan A high volume, programmeable moisture heat sterilisinginstruments. An essential unit for all microbiology lab.We work on bacteria on a daily basis and needs this unit forsterilisation and killing of microbes.3-phase plug point needed, which has beencommunicated to Estate Office (JPPHB) in UM. We needthis instrument to comply with Biosafety requirement asstipulated by Biosafety Act 2007 and IBC ruling.All microbiologists.Very frequently used by all groups (5 days per week,6 hr per run)6 Nanodrop 50,000 50,000 - 50,000 1 USA NanoDrop is a spectrophotometers and fluorospectrometerused to quantitatemicro-volumes of sample.NanoDrop instrument is needed for diverse fields such as genomics, This instrument is required for NGS work for nucleic acids All genomic works requires this instrumentsproteomics, drug discovery, molecular diagnostics and biomanufacturing.It is based upon the patented sample retentionmy group.(DNA, RNA) intergrity prior to NGS work.involving molecular biologist and bacteriologist insystem that allows scientists to quickly and easily quantify andassess purity of samples such as proteins and nucleic acids.Very frequently used by all groups (5 days per week,1 hr per run)7 Qubit 12,000 12,000 - 12,000 1 USA Qubit quantitates DNA, RNA, and protein with unprecedented It is designed for precious samples that are rare or difficult toaccuracy, sensitivity,process, and applications requiring precise measurement such asand simplicity. It is designed for molecular biology labs that qPCRwork on genomic work.8 Table Top centrifuge 86,000 86,000 - 86,000 1 USA This is an essential instrument for correct speed control Our team needs to centrifuge bacteria cells that must rely on thiscentrifugation that is needed to spin down small particles instrument.including proteins and viruses. It will have a temperaturecontrolledchamber for heat sensitive samples.This instrument requires no special electricity and space All molecular biologists in my group.requirement. It is a small instrument. It is needed for NGSand qPCR work.This instrument requires no special electricity and space All microbiologists.requirement. It is a small instrument.Very frequently used by all groups (5 days per week,1 hr per run)Very frequently used by all groups (5 days per week,mins - 0.5 hr per run)9 Termomixer 48,000 48,000 - 48,000 2 USA It simultaneous mixing and temperature control. its countercoolingability provides efficient cooling thereby greatly small volume enzymatic reaction involving restriction enzymes, requirement. It is a small instrument.We do gene cloning work that needs special temperature control of This instrument requires no special electricity and spaceexpanding both Its temperature control functions and range ligases, and DNase and RNases. We need this accurate temperatureof applications.control heat block that fits small eppendorf tubes for ligation,inactivation of enzymes and heat inactivation of quorum quenchingassay.10 Lab freezers and12,000 12,000 - 12,000 2 USA/Malaysia Upright Freezers and fridges, 4 degree Celcius to -20 degree To store our valuable, hundreds of bacteria stocks and heat This instrument requires no special electricity and spacefridges/Japan Celcius, respectively. These instruments come with anti-frost sensitive chemicals notable quorum sensing and natural products requirement. It is a small instrument.and and auto-defrost functions.molecules.11 Workstation 140,000 140,000 - 140,000 2 USA This workstation is a computing solution for genome analyzer We have tens to hundreds of bacteria genomes to be analysed and This instrument requires no special electricity and spacesequencing platforms. It bundles with sequencing software without this workstion; analysis of these tera bases of DNA will requirement. It is a table-top size instrument. Thewith high-performance workstation to perform gene virtually impossible.softwares bundled with is one-off payment, and noannotation and genome data analysis.renewal needed.All bacteriologists.Very frequently used by all groups (5 days per week,1 - 24 hr per run)All users in the lab.Use daily (24 hr / week) non stop.Bioinformatics and GWAS researchers in my group. Use daily, data analysis can run up to 24 hr/week) forfew days for complex data.12 Ice maker 11,000 11,000 - 11,000 1 USA It is a stand-alone appliance to make ice that the size is We have no ice maker currently and unable to control the heatgraded and suitable for molecular work. We routinely needs senstive experiments.these special shape ice to cool molecular grade reagents andexzymes including the PCR reagents.This instrument requires no special electricity and spacerequirement. It is a small instrument and need a watersupply.All users in the lab.Use daily (24 hr / week) non stop.13 Optical Mappingsystem14 Essential molecularlab equipments(hotplate, magneticstirer, microfuge,microwave,electrophoresis tanketc)270,000 270,000 - 270,000 1 USA This instrument enables the user to generate the optical We have tens to hundreds of bacteria genomes to be analysed. In This instrument requires no special electricity and space Bioinformatics and GWAS researchers in my group. Frequently use (5 day per week) for genome analysis,maps in the labs, generate microbial whole genome maps addition to NGS analysis, we attempt to study the optical consensus requirement. It is a small instrument .9 hr-24 per analysisfrom single DNA molecules. It is a non gel-based, PCR-based, map that accurately show relatedness, chromasomal genomic mapon-the-chipand automated in silico genomic map. This is one of theor sequencing based methodology. It provides strain typing,comparative genomics, whole genome sequence assembly latest technology to study bacterial genomes.with user friendly built-in software.10,000 10,000 - 10,000 5 USA/Germany/ These are small but essential instruments for daily operation These items are typically available in all modern lab, and we need These instruments require no special electricity and space All users in the lab.Use daily (8 hr/day). Application usually from few minJapan/Malaysia of the labs. We need to acquire these to cope with the these to support our work or other major instruments. Some items requirement. It is a small instrument .to hours.increased demand to fulfil our KPI and to provide support for in my lab are too old and inaccurate to operate.the big instruments.15 Microfluidicbioanalyser120,000 120,000 - 120,000 1 USA Small instrument for sizing, quantification and quality control This unit can shorten biosamples (DNA, RNA, proteins) analysisof DNA, RNA, proteins and cells. This instrument is the lab-onthe-chipthat uses microfluidics technology for the analysis of confirmation that is recommended for personlaised genomefrom hours to miins. Also, it is an essential for sample integritybiological samples.analyser that we had bought.This unit can provide improved data precision and All users in the lab.reproducibility, short analysis times,minimal sample consumption, improved automation andintegration of complex workflows.Use frequently (5 days per week, 1-2 hr per run).1,627,000.00 1,627,000.00 0.00 1,627,000.00- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (CHANCELLORY)No PI's Name Title EquipmentEstimated budgetYear 2 & 3(2012 & 2013 )Approved Budget (After VM Lab)2012 (RM) 2013 (RM) Total (RM)Quantity/unitCountry oforiginDetailsJustification ofpurchaseAdditional information(space/utilities eg electric, software etc)Potential users/research groupsFrequency and intensity of usage2 Prof. Dr. Jamuna Molecular Genetics 1 3500xl de novoVaddiveluGenetic Analyzer1,600,000 1,600,000 - 1,600,000 1 USA 3500xl de novo genetic analyzer is a medium-to-highthroughput Sanger sequencer for sequencing, resequencing,mutation detection, AFLP analysis, SNPgenotyping, relative fluorescent quantitation,microsatellite analysis and other genetic applications.3500xl de novo genetic analyzer is one of the most versatile Lab space (13'x13' with air-con) has been allocated Potential users including geneticists, molecular Frequently used (6 days per week) and eachsequencer in the market. This equipment is not available in in the HIR Building and approved by the civil, biologists and microbiologists involved in run will take at least 1 hour.UM despite the high demand for such 24-capillarymechanical & electrical departments. Genome sequencing, re-sequencing, mutation detectionsequencing facility. For instance, the Molecular Genetics sequences and gene annotation analysis softwares and other genetic applications. At least 10 PhDteam will be embarking on a large-scale sequencing study on are included. Without this instrument, large scale and MSc students will be trained using therespiratory, gastrointestinal, central nervous system, and genome sequencing projects will be negetively instrument, producing results that could beblood-borne pathogens. Availability of 3500xl is essential and affected.published in Tier-1 journals including Nature,timely to produce tier-1 publications (Proc Natl Acad Sci U SScience, Lancet, PLoS, PNAS, Journal ofA. 2010 Dec 21;107(51):22032-7, Proc Natl Acad Sci U S A.Virology, Emerging Infectious Diseases and2010 Jul 13;107(28):12629-33).others.2 Multiplex, BeadbasedFluoroanalyzer400,000 400,000 - 400,000 1 USA A multiplex, bead-based fluoroanalyzer is a platform Fluoroanalyzer that operates on the xMAP technology Lab space (13'x13' with air-con) has been allocated Broad users including molecular biologists,Frequently used (3 days per week) and each run willthat simultaneously measures multiple analytes by enables bead-based multiplexing of up to 500 analytes per in the HIR Building and approved by the civil, immunologists and geneticists involved in varioustake at least 2 hours.exciting a sample with a laser, and subsequently specimen. Together with the Luminex 100/200 analyzer that mechanical & electrical departments. xMAPapplications in enzyme, nucleic acid and proteinanalyzing the wavelength of emitted light using protocolbaseddata acquisition with robust data regression fast and cost-effective bioassay results on many assay software are included in the platform for operation. trained using the instrument, producing results thatruns on the principles of flow cytometry, the system delivers technology, MAGPIX imaging system and xPONENT studies. At least 10 PhD and MSc students will beanalysis. A fluoroanalyzer combines advanced fluidics, formats including nucleic acid assays, receptor-ligand Without this instrument, studies using large-scale could be published in Tier-1 journals includingoptics, and high-speed digital signal processing with assays, immunoassays and enzymatic assays. The bead-based bioassays will be negetively affected.Nature, Science, Lancet, PLoS, PNAS, Journal ofcolor-coded microsphere technology to deliver Molecular Genetics team will be embarking on a large-scaleVirology, Emerging Infectious Diseases and others.multiplexed assay capabilities.surveillance study on respiratory and gastrointestinalpathogens using the xTAG RVP and GPP assays,respectively. Availability of bead-based multiplexingfluoroanalyzer is therefore essential and timely to producetier-1 publications (PLoS One. 2011;6(9):e24734, J ClinMicrobiol. 2011 May;49(5):1738-44).3 High-resolutionProteomics andMetabolomicsAnalyzer withmicrofluidicseparationcapability4 Epifluorescenceinvertedmicroscopeequiped with CCDcamera.1,800,000 1,800,000 - 1,800,000 1 USA The 6000 series Proteomics and Metabolomics Proteomics and metabolomics forms the core technological Lab space available in HIR Building. Meeting withAnalyzer has become the choice of analytical tool for backbone of our Helicobacter pylori research at UM. Only architect, mechanical & electrical engineer done tothe study of proteins and their associated posttranslationalmodifications as well as cellularwhich is not upgradable to fulfil current proteomics andone older model is currently available in UM (Chemistry) make avaiable a22'x22' room with air-conditioning.metabolites. The high sensitivity and resolution of the metabolomics research needs. The resolution of thisanalyzer enables it to be applied to meta-analysis of proposed unit is 10 times higher than the older unit. Othercomplex clinical and environmental samples. It is widely MS instruments in UM do not meet requirement in terms ofapplied to drug discovery, biomarker discovery, cancer sensitivity and resolution. Without this, it is unable toresearch, environmental research, etc.determine the accurate mass of unknown compounds(especially that of larger molecular weight compounds likeproteins which falls outside the detection range ofconventional quadrupole mass spec analyzers). Also, theexisting older unit is already heavily utilized and long queuetime will delay progression in research work. The proposednew unit will cut short the waiting time, reduce cost,increasing resolution and accuracy of molecular massmeasurement. In addition to that, the proposed unit will beequipped with state-of-the-art proprietary softwares toanalyze complex data, predict molecular functions andbiological pathways. Similar work has been performed by ourcollaborative partners at A*STAR Singapore andMetabolomics Network Australia reulting in high impactpublications. It would therefore be ideal to mirror this work inour facility so that our human resource capacity can be builtup and we can reduce time of obtaining resutls and notdepened on international sources. This instrument isimportant for publication in Tier-1 journals e.g. J. BiologicalChemistry, Cell, Science, Nature, Nature Biotech, NatureGenetics, Nature Materials, PNAS, etc. (Nature Protocols2011 vol. 6, 1060–1083; PNAS March 10, 2009 vol. 106 no.10 3698-3703)300,000 300,000 - 300,000 1 Japan / USA For study of tissue samples, living cells and its To give a better view of biological function through the study Lab space available in HIR Building.components. Specific fluorochrome staining or of cellular dynamics. As fluorescence fades, it is essential torecombineering with GFP allows investigation into have the epifluorescence microscope nearby for immediatemolecular physiology and activity.viewing.2 HIR-funded projects:Estimated usage: heavily utilized;(1) Interspecies molecular crosstalk in H. pylori average of twice or 2 weeks of 24 hrs continuousinfections;running per month (exclude possible usage by other(2) Antimicrobial susceptibility of H. pylori isolates; research groups in UM)At least 4 PhD students in our research group.Allows students to be trained in proteomics andmetabolomics.Also can be used by other UM research groups indrug discovery, biomarkers cancer research andenvironmental research.Expected no. of Tier-1 papers from 2 projects: 19Potential users including geneticists, molecular Heavily used (5 days per week) and each usebiologists and microbiologists involved in will take about 30 min to a few hours.animal, plant, bacterial and viral work. At least3 PhD student and 4 M Sc students will betrained using the instrument, producing resultsthat could be published in Tier-1 journalsincludingImmunity, Molecular Cell, Genes &Development,Proceedings of the National Academy ofSciences of the United States of America(PNAS) and others.5 Cryopreservation180,000 180,000 - 180,000 1 USA For cryopreservation of biopsy samples, cell lines,The aim of cryopreservation is to enable stocks of cells to be Lab space available in HIR Building.2 HIR-funded projects: (7); Regulation ofDaily used ( 7 days per week)system for biopsytissues and stock culture. For long term storage ofstored to prevent the need to have all cell lines in culture atImmune Response by Epigenetics and (8)samples, cell lines,RNA and protein samples.all times. It is invaluable when dealing with cells of limited lifeGenome Organization in Diseases: fromtissues and stockspan. The other main advantages of cryopreservation are:Mutations to Structural Variations andculture* Reduced risk of microbial contaminationEpigenetics* Reduced risk of cross contamination with other cell lines* Reduced risk of genetic drift and morphological changes* Work conducted using cells at a consistent passagenumber* Reduced costs (consumables and staff time)6 Thermal cycler (9690,000 90,000 - 90,000 3 USA For amplifying segments of DNA via the polymeraseTo conduct research studies in gene expression, mutation,Lab space available in HIR Building.Potential users including geneticists, molecular Heavily used (6 days per week) and each runwells)chain reaction (PCR) process.sequencing and cloning. Current units (2) in the lab is fullyMinor renovation, furnishing & maintenance.biologists and microbiologists involved inwill take at least 2-3 hours.utilized and not sufficient to meet requirement of project. Theanimal, plant and bacteria work. Results couldamount of research work involving a lot of genotypingbe published in Tier-1 journals includingdemands additional 3 units.Immunity, Molecular Cell, Genes &Development,Proceedings of the National Academy ofSciences of the United States of America(PNAS), PLoS Genetics, Medical Genetics andothers.7 Bioinformatics80,000 80,000 - 80,000 1 USA /To facilitate storage and rapidly process huge amountLarge amount of data expected from this project due to the2 HIR-funded projects: (7); Regulation ofFrequently used and complete data analysissoftware forDenmarkof genetic datahigh throughput approach.Immune Response by Epigenetics and (8)require days to weeks run on a workstation.GWAS, ChIPGenome Organization in Diseases: fromsequences andMutations to Structural Variations andgenome wide geneEpigenetics. Results could be published in Tier-expression analysis1 journals includingetc, data storageImmunity, Molecular Cell, Genes &and processingDevelopment,Proceedings of the National Academy ofSciences of the United States of America(PNAS), PLoS Genetics, Medical Genetics andothers. Other potential users includebioinformaticians and biologists.- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (CHANCELLORY)No PI's Name Title EquipmentEstimated budgetYear 2 & 3(2012 & 2013 )Approved Budget (After VM Lab)2012 (RM) 2013 (RM) Total (RM)Quantity/unitCountry oforiginDetailsJustification ofpurchaseAdditional information(space/utilities eg electric, software etc)Potential users/research groupsFrequency and intensity of usage8 Large bench80,000 80,000 - 80,000 1 UK/For big scale separation and characterization ofTo separate different types of sample size fromLab space available in HIR Building.Potential users including geneticists, molecular Frequently used (3 days per week)centrifugeUSA/macromolecule, subcellular and cellular components in microcentrifuge tube to 250ml culture tube. None existing inbiologists and microbiologists involved inGermanybiochemistry, cellular and molecular biology andthe lab. Big scale separation and characterization ofanimal, plant and bacteria work.medicine.macromolecule should be done immediately9 Gel documentation60,000 60,000 - 60,000 1 USA For the imaging and documentation of nucleic acid and To analyse and study DNA fragment from agarose gelLab space available in HIR Building.Potential users including geneticists, molecular Heavily used (6 days per week)systemprotein polyacrylamide or agarose gels typically stained electrophoresis. Current unit is located far away from HIRbiologists and microbiologists involved inwith ethidium bromide or other fluorophores such asBuilding.animal, plant and bacteria work. Results couldSYBR Green.be published in Tier-1 journals includingImmunity, Molecular Cell, Genes &Development,Proceedings of the National Academy ofSciences of the United States of America(PNAS), PLoS Genetics, Medical Genetics andothers.10 Refrigerated55,000 55,000 - 55,000 1 UK/USA/For the separation and characterization ofTo separate different types of sample size fromLab space available in HIR Building.2 HIR-funded projects: (7); Regulation ofDaily used ( 7 days per week)centrifugeGermanymacromolecule, subcellular and cellular components in microcentrifuge tube to 250ml culture tube but at lowImmune Response by Epigenetics and (8)biochemistry, cellular and molecular biology andtemperature. None existing in the lab. Cells need to beGenome Organization in Diseases: frommedicine at low temperature.processed immediately.Mutations to Structural Variations andEpigenetics11 Carbon dioxideIncubator12 Class II BiologicalSafety Cabinetswith HEPA-filtered13 Proteinelectrophoresis andwestern blotting set14 Thermal cycler(384 wells)50,000 - 50,000 50,000 2 USA For routine culturing of animal, human and cancer cells. A basic and standard equipment for routine cell culturing and Cell culture room will be setup in HIR Building. 2 HIR-funded projects: (7); Regulation of Daily used ( 7 days per week)conducting cell-based experiments. Current CO2 incubator inImmune Response by Epigenetics and (8)the lab is fully utilized and not sufficient to meet requirementGenome Organization in Diseases: fromof project. To minimize contamination, we need new units inMutations to Structural Variations andthe HIR building.Epigenetics60,000 60,000 - 60,000 2 USA An enclosed, ventilated laboratory workspace for safely As tissue culture work is prone to contamination, it is Cell culture room will be setup in HIR Building. 2 HIR-funded projects: (7); Regulation of Heavily used (6 days per week)handling of cells and conducting cell-basedessential to have a dedicated facilities.This system isImmune Response by Epigenetics and (8)experiments.important for collaborative work with Caltech. None in theGenome Organization in Diseases: fromHIR Building.Mutations to Structural Variations andEpigenetics.100,000 100,000 - 100,000 2 USA For separating proteins ranging in size from 5 to 2,000 To separate proteins according to their electrophoretic Lab space available in HIR Building.2 HIR-funded projects: (7); Regulation of Heavily used (6 days per week). Each run willkDa due to the uniform pore size provided by the mobility (function of the length of a polypeptide chain and itsImmune Response by Epigenetics and (8) take about 30 min to a few hours.polyacrylamide gel and blotting of the protein to charge) and to blot it to membrane for protein detection.Genome Organization in Diseases: frommembraneExisting facility is not enough to meet the requirement of theMutations to Structural Variations andproject.Epigenetics. Results could be published in Tier-1 journals includingImmunity,Molecular Cell, Genes &Development,Proceedings of the National Academy ofSciences of the United States of America(PNAS), PLoS Genetics, Medical Genetics andothers40,000 40,000 - 40,000 1 USA For amplifying segments of DNA via the polymerase To conduct high throughput research studies in gene Lab space available in HIR Building. Can be placed 2 HIR-funded projects: (7); Regulation of Heavily used ( at least 3 days per week). Eachchain reaction (PCR) process.expression, mutation, and sequencing. None existing. in Institute of Biological Sciences labImmune Response by Epigenetics and (8) run will take about 30 min to a few hours.Genome Organization in Diseases: fromMutations to Structural Variations andEpigenetics. Results could be published in Tier-1 journals includingImmunity, Molecular Cell, PLoS Genetics,Medical Genetics. Other potential usersincluding UM Scientists working in drugdiscovery, genetics, pharmacogenomics,bacterial, molecular biology and cancer work.15 Centrifuge 30,000 30,000 - 30,000 2 USA For the general separation and characterization ofFor a quick, easy, and economical way to spin down microLab space available in HIR Building.2 HIR-funded projects: (7); Regulation ofHeavily used (6 days per week).macromolecule, subcellular and cellular components in samples, perform microfiltration work and cell separations.Immune Response by Epigenetics and (8)biochemistry, cellular and molecular biology andGenome Organization in Diseases: frommedicine.Mutations to Structural Variations andEpigenetics.16 Autoclave machine 30,000 30,000 - 30,000 1 Japan An instrument to sterilize equipment and supplies byMost of the equipment and supplies must be sterilized before Lab space available in HIR Building.2 HIR-funded projects: (7); Regulation ofHeavily used (6 days per week).subjecting them to high pressure saturated steam.conducting an experiment. Besides, all biohazard wasteImmune Response by Epigenetics and (8)materials produced from the experiment must be sterilizedGenome Organization in Diseases: frombefore discarding. Current unit (1) in the lab is fully utilizedMutations to Structural Variations andand not sufficient to meet requirement of project.Epigenetics.17 Chromatography Refrigerator 25,000 25,000 - 25,000 2 USA For storage of chemicals, DNA, reagents andTo store chemical, DNA, reagents and to conduct experimentLab space available in HIR Building.2 HIR-funded projects: (7); Regulation ofDaily used ( 7 days per week)conducting experiment at 4°C.that required 4°C .Immune Response by Epigenetics and (8)Genome Organization in Diseases: fromMutations to Structural Variations andEpigenetics.18 Gel dryer 10,000 10,000 - 10,000 1 USA For drying polyacrylamide gels To dry the polyacrylamide gel from SDS-PAGE. NoneLab space available in HIR Building.2 HIR-funded projects: (7); Regulation ofFrequently usedexisting.Immune Response by Epigenetics and (8)Genome Organization in Diseases: fromMutations to Structural Variations andEpigenetics.19 Micro-Volume Full-SpectrumFluorospectrometer100,000 100,000 - 100,000 1 Highly accurate measurment of DNA, RNA and protein Routinely needed for the required project, and for measuring Lab space available in HIR Building.concentrations utilizing micro volume amounts. precious amounts of DNA, RNA and protein accurately. Minor renovation, furnishing & maintenance.None existing.2 HIR-funded projects: (7); Regulation of Heavily used (6 days per week). Each time willImmune Response by Epigenetics and (8) take about about 30 min to a few hours.Genome Organization in Diseases: fromMutations to Structural Variations andEpigenetics. Other potential users includinggeneticists, molecular biologists, biochemists,and microbiologists.20 Sonicator 50,000 50,000 - 50,000 1 Rapid disruption of cells for DNA, RNA and protein Routinely needed for the required project, The use of a Lab space available in HIR Building.2 HIR-funded projects: (7); Regulation of Frequently used.extraction and purification. Also for homogenization. sonicator for cell disruption minimizes contamination, andImmune Response by Epigenetics and (8)allows faster work flow. None available.Genome Organization in Diseases: fromMutations to Structural Variations andEpigenetics. Other potential users includinggeneticists, molecular biologists, biochemists,chemists and microbiologists.21 COBAS Taqman 48360,000 - 360,000 360,000 1 USA COBAS Taqman 48 Analyzer is an automated system COBAS Taqman 48 Analyzer is one of the most versatile realtimeamplification and detection system of DNA or RNA in in the HIR Building and approved by the civil, biologists and microbiologists involved in real-will take at least 3 hours.Lab space (13'x13' with air-con) has been allocated Potential users including geneticists, molecular Heavily used (6 days per week) and each runAnalyzerfor real-time amplification and detection of DNA or RNA.Up to 2 medium-throughput assays can be performed in the market. This equipment is not available in UM despite mechanical & electrical departments. AMPLILINK time amplification, detection and quantitation ofthe same footprint, allowing various protocols to be the high demand for such real-time amplification facility. For operational software is included for total automated DNA or RNA. At least 10 PhD and MScused at the same time. The COBAS system is also instance, the Molecular Genetics team is embarking on a solution. Without this instrument, genetic projects students will be trained using the instrument,highly compatible with various FDA-approvedlarge-scale sequencing study on respiratory, gastrointestinal, requiring an automated system for real-time producing results that could be published inRNA/DNA kits, for example, the HIV, HCV and the HBV central nervous system, and blood-borne pathogens. amplification and detection of DNA or RNA will be Tier-1 journals including Nature, Science,qualitative/quantitative assays, offering the optimal Availability of COBAS Taqman 48 Analyzer is essential and negetively affected.Lancet, PLoS, PNAS, Journal of Virology,solutions for clinical diagnostics and research. timely to produce tier-1 publications (J Clin Microbiol. 2011Emerging Infectious Diseases and others.Jan;49(1):377-9, J Clin Microbiol. 2005 Jul;43(7):3504-7).5,500,000.00 5,090,000.00 410,000.00 5,500,000.00- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (CHANCELLORY)No PI's Name Title Equipment3 Assoc. Prof. Dr. TunkuAtomic forceStem Cell 1Kamarul ZamanmicroscopyEstimated budgetApproved Budget (After VM Lab)Quantity Country ofJustification ofAdditional informationYear 2 & 3Details/unitoriginpurchase(space/utilities eg electric, software etc)(2012 & 2013 )2012 (RM) 2013 (RM) Total (RM)3,500,000 3,500,000 - 3,500,000 1 Korea AFM is used to measure the surface topography and to AFM finds various application from tissue to scaffold engineeering. Space is available at Molecular Biotechnology lab. Theinvestigate the surface forces on the nanoscale level (from The resolution of image generated is of very good quality for high software for image analysis and a desktop computer isAngstroms to 100 microns) of the biological samples, impact publications. This instrument is superior over other model also included with this equipment.nanofoibres, and engineered scaffolds. Can serve as a tool to and contains both contact and non-contact imaging.study the mechanical properties of individual cells andadhesion forces between the cells, a wide variety of cellmechanism from cell development, cytoskeletal changes andapotosis can be probed and visualized. Currently AFMtechnology is rapidly adding new capabilities to detect variousphysical properties and manipulating biological entities.3,500,000.00 3,500,000.00 0.00 3,500,000.00Potential users/research groupsFrequency and intensity of usageUsers of AFM includes: biologist, pharmacologist, Used 2 days per week and each live cell imagingmolecular biologist and medical scientist performing experiment will run upto 48 hours.live cell imaging and ion conductance study.Good quality images obtained through live cellimage and surface topography can be used for Tier 1Publications.4Dr C H Raymond OoiQuantum and LaserScience1 Spectrometer anddetecter100,000 100,000 - 100,000 1 Singapore High resolution spectrometer that can resolve vibrational spectra High resolution spectrometer that can resolve vibrational spectra2 Ultrashort pulsedetection system3 Laser diode andcontroller80,000 80,000 - 80,000 1 Singapore Characterization of ultrashort laser pulse Not available. Necessary for ultrafast optical pulse20,000 20,000 - 20,000 1 Malaysia For probing and controlling sample Necessary for probing sample in multiphoton parametricexcitations4 Tunable laser sources 50,000 50,000 - 50,000 1 Singapore Tuning frequency across atomic/molecular resonances Not available. Needed for studying the effects of frequency at andoff resonance.5 Optical detector /CCD 10,000 10,000 - 10,000 1 Malaysia Camera can display high resolution images rapidly Not available. Needed for obtaining microscopic images6 Single photondetectors7 Optical amplifiers/oscillator10,000 10,000 - 10,000 1 Singapore For sensitive detection of few photons Not available, necessary for detecting studying quantum properties40,000 40,000 - 40,000 1 Singapore For amplifying laser pulse Not available. Needed for amplifying laser pulses for nonlinearoptics processes8 Optical table 100,000 100,000 - 100,000 1 Singapore For anti-vibration and stable optics Needed as a platform for optical experimentation9 Autocorrelator andcross correlator10 Acousto opticmodulator /SLM10,000 10,000 - 10,000 1 Malaysia For correlation measurement Not available. Necessary for photon correlation measurement10,000 10,000 - 10,000 1 Malaysia For creating sidebands in spectra Not available. Necessary modulating signal and making newfrequencies11 Stern Geriach magnet 5,000 5,000 - 5,000 1 Singapore For separating particles in different quantum states Not available. Needed for testing Maxwell demon concept andquantum thermodynamics12 Microwave/maserand cavity5,000 5,000 - 5,000 1 Singapore For inducing Zeeman coherence Not available. Necessary for controlling quantum coherence ofstatesWe are initiating quantum optics and nonlinear opticsresearch at atomic and molecular levels never beenexplored in Malaysia before. It is a major step forward,leading to futuristic optical technologies that incorporatequantum effects. The measurement equipments andoptics are different from those in photonics and opticalcommunications. This effort will produce high impact Tier1 papers and enables Malaysia to acquire the rapidlyadvancing state-of- the-art quantum science andtechnology.Researchers from quantum and ultrafast laserscience group will assemble the equipments forconducting novel research ideas. PIs andcollaborators in UM, postgraduate students, andpostdoc will be the users who will benefit from theequipments for studying quantum properties ofphotons and spectroscopic properties of atoms andmolecules. These equipments will enable UM todevelop the state of the art expertise in quantumand laser research, and promote interdisciplinaryresearch topics that will produce publications in Tier1 journals such as Physical Review Letters, NaturePhotonics. At least 5 PhD and 3 MSc students will betrained using these instruments.These ceqyipments are connected to construct noveloptical experimentations involving photons andatoms. They will be used regularly.13 Gas/vapor cell 5,000 5,000 - 5,000 1 Malaysia For high precision control of quantum states for newquantum optics effectsNot available. The narrow natural linewidth of gas is ideal forexploring quantum optics techniques without using solid materials14 Prisms, mirrors,gratings, beamsplitter, polarizers100,000 100,000 - 100,000 1 Malaysia For amplifying stretching and compression of ultrashort laser Not available. The components are necessary for amplifying andpulsesshaping the spectral properties of laser pulses545,000.00 545,000.00 0.00 545,000.00- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (CHANCELLORY)Estimated budgetApproved Budget (After VM Lab)Quantity Country ofJustification ofAdditional informationNo PI's Name Title EquipmentYear 2 & 3DetailsPotential users/research groups/unitoriginpurchase(space/utilities eg electric, software etc)(2012 & 2013 )2012 (RM) 2013 (RM) Total (RM)5 Prof Rauzah Hashim Fundamental Science of 1 Small and Wide Angle1,890,000 1,890,000 -1,890,000 1Japan/ Suitable powerful X-ray generator; eg. X-ray sealed Small and Wide angle X-ray system to study the strcuture for This will be a stand alone equipment. We shall place Researchers that needing this equipmentsSelf AssemblyX-Ray ScatteringAustria/ tube (with at least 3kW output);soft matter eg. liquid crystals, lipid phases, nanomaterials, this M008A-M007. Some renovation is required. includes Prof. Wan Haliza, Prof. Misni Misran,SystemGermany Tuning device; platform to hold the generator ,protein etc.. This is different from the usual X-ray system for Two units of air-conditioners, with 2.5 horse power Dr. Huang, Dr. Koshy Philips, Dr. Hairol, Dr.Focusing multi-layer optics; software for datacrystal structures, which has only wide angle capability. each. Electrical wiring, power supply and DB Rusnah, Dr. Lim Hong Ngee, Dr. Norbani andacquisition, data evaluation software, Vacuuminstallation. This system is to be used routinely for Zamani involving researchers from 3 differentequipmentformulation studies, nanomaterials, colloids and research centres.There are powder X-ray systems, but these only handles interface sciences.Sensitive Detection of the scattering signal, for example materials in the solid state or liquid. Soft matter is neitherimaging plate reader with read-out software, Carousel solid nor liquid. Therefore special sample holder to handle Many collaborations with eminent scientists includingfor imaging read-out of SAXS or WAXS measurements, paste-like materials is crucial. Furtheremore, the small angle X- Prof. Seddon from Imperial College, Prof. C. Solansdevice for erasing the imaging plates after read-out, 2 ray scattering system has lower angle down to 0.01 degree as and Dr. Esquena (CSIC, Barcelona) and Dr. ConnsImaging plates for SAXS and SWAXS. Similar alternative compared to powder X-ray system. This enable the system to (Melbourne).is possible.probe materials in the range of 1-100 nm size.Three students from UM have been trained on smallCapable for simultaneous small- and wide- angle Since some of the phases are difficult to grow, we need a and wide angle X-ray, namely Hairol Amani, Nor Idayumeasurements in the angular range between 0° and 40°. powerful X-ray generator source as well as highly sensitive Mohamad Zaid and Noraini Ahmad. Prof Rauzah hasdetector.been working with the x-ray system in the overseaAdjustable sample holder unit with resistance heater forcollaborators lab for the past few years undermeasurements from below the room temperature to For Liquid Crystal application we need:research attachment and sabbatical research. Dr.about 300 °C,Huang is also one of the researcher who has been1. Vacuum beam path (this is to avoid air scattering) actively using SAXS for liquid cystal andTemperature control unit for exact temperature controlnanomaterials characterization during his PhD study.and Humidity Cell.2. Liquid Crystal sample holder (able to fill sample without any One external examiner for a Ph.D. thesis in 2010Sample holder for the measurement of high-viscosity induced effect on structure)commented that the thesis work lack intromations onsamples. Automatic sample changer for 10-15 samplesstructure from SWAXS .for continuous measurements at prefered oreintation. 3. Simultaneous SAXS and WAXS data (capture all informationVariable temperature attachementsin single experiment)Our work has been published for the X-ray studies ofCell for the measurement of sedimenting samples and 4. Temperature-dependent study from Low to high temp (-150 a range of glucosides in 2011.the investigation of reactions (e.g. nucleation processes) deg to 300 deg),Daily heavily used.Frequency and intensity of usageSample holder for the measurement of “precious” 5. Liquid Crystal orientation measurement (able to capture all 1. Invited articles: Thermotropic and lyotropic liquidsamples (e.g. protein samples) and allows to recover the possible orientation)crystalline phases of Guerbet branched-chain β-Dglucosides.Nicholas J. Brooks , Hairul A.A. Hamid ,sample after the measurement.6. Automatic sample absorption correction abilityRauzah Hashim, Thorsten Heidelberg, John M.Prefer rotating sample holder for samples during theSeddon, Charlotte E. Conn, Seyed M. Mirzadehexperiment and to prevent sedimentation or floating of 7. Phase Transitions studyHusseini, N. Idayu Zahid and Rusnah Syahila Dualithe particles in dispersions. As well as to map the phaseHussen, Liquid Crystals, Vol. 38, Nos. 11–12,diagram.8. Liquid Crystal Kinetic studyNovember–December 2011, 1725–1734Front illuminated CCD detector, 2084 x 2084 pixels, 24μm x 24 μm pixel size optimized for 8 keV X-rays,including - Peltier cooling - Camera controller, PCIInterface and Software. UPS, Licenced software etc.2. Physico-Chemical Characterization of Natural-LikeBranched-Chain Glycosides towards Formation ofHexosomes and Vesicles Noraini Ahmad, RolandRamsch, Jordi Esquena, Conxita Solans, Hairul AnuarTajuddin, Rauzah Hashi. Submitted toLangmuir.3. Influence of Branched-Chain Alkyl Glycosides onNano-Emulsions of a Ternary System forPharmaceutical Applications, Ahmad, N., Ramsch, R,Llinas, M., Solans, C., Hashim, R. and Tajuddin, H. A.,European Journal of Pharmaceutical Sciences,Submitted.2 Instrument:Microfluidizer (highshear fluid processor)160,000 - 160,000 160,000 1 US/Europe Top-down nanoparticle (nanoemulsion) processing, shear The application of high shear extrusion enables a reduction of Stand alone benchtop system with standard 2-phaserate of up to 12,000,000 s-1 at pressure of ~30,000 psi, particle size for formulation of vesicles as well as for emulsions with electric supply and no special room requirements; labvolume up to 5 mLnarrow size distribution. Conventional techniques without these space for placement in M008b available; no specialfeature usually lead to larger aggregation sizes, which affects the maintenance of equipment and no updating of softwarepotential for applications. Vesicles for delivery purposes commonly or databases required. To be used frequently forrequires small sizes to ensure compatibility with blood stream formulation studies. Scientists who will be using thistransport. Material development studies, both academically and equipment include, Dr. Thorsten Heidelberg, Dr. Rusnah,application targeted, are monitored critically on the aggregation Dr. Huang, Dr. Hairol Prof. Misni, Dr. Suffian.size. A suitabe instrument is currently not accessible for theresearch.2,050,000.00 1,890,000.00 160,000.00 2,050,000.00- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (CHANCELLORY)No PI's Name Title EquipmentEstimated budgetYear 2 & 3(2012 & 2013 )Approved Budget (After VM Lab)2012 (RM) 2013 (RM) Total (RM)Quantity/unitCountry oforiginDetailsJustification ofpurchaseAdditional information(space/utilities eg electric, software etc)Potential users/research groupsFrequency and intensity of usage6 Prof. Yip Cheng HarBreast CancerITL Lab :-1 Basic lab equipmentand freezers616,500 - - 0 1 Various sources These basic equipment for the ITL are lsited separately in Appendix Space will be in the paediatric lab in the new paediatric1 and are required to set up the labtower, UMMC. The HIR Breast project, together withUMCRI, will set up a research pathology lab, and requirethese basic equipment for the set up. The researchpathology lab can be also used by others.Ceria, Gynaeoncology.Full time, with 2 post docs2 Violet laser 110,000 110,000 - 110,000 1 USA The current FLOW can only tag 6 colours and further laser tocharacterize the cellsResearch Pathology Lab :-3 Automatic IHCStainer (VentanaDiscovery)4 Microtome (ThermoScientific)500,000 500,000 - 500,000 1 Switzerland The automated IHC system is recommended as it generates a moreconsistent and reproduce able staining patterns both within andbetween histological batches (UKNEQAS).80,000 80,000 - 80,000 1 USA The compact research microtome has extraordinary high stabilityallowing quick trim feature at 10-30 microns and a section counter.5 Cryostat120,000 120,000 - 120,000 1 USA 'The basic cryostat is for processing snap frozen research samples.(Thermoscientific)Space will be in the paediatric lab in the new paediatric6 Fumehood (ESCO) 35,000 35,000 - 35,000 1 Singaporetower, UMMC. The HIR Breast project, together with7 Paraffin embedder80,000 80,000 - 80,000 1 USA The automated paraffin embedder allows individual programing of UMCRI, will set up a research pathology lab, and require(Thermoscientific)all temperatures and automatic consideration of pre-heating times these basic equipment for the set up. The researchThe breast, colorectal, urology and gynaecologicalallowing for consistency.pathology lab can be also used by other research groups.cancer teams all have projects requiring the use of8 Shaking incubator30,000 30,000 - 30,000 1 KoreaBesides immunohistochemistry work, this is a diagnosticimmunohistochemistry. This equipment will have(Labtech)and translational facility where transfection and functional9 Light microscope with200,000 200,000 - 200,000 1 hungary The microscope with digital slide scanning capabilities (virtual slidemultiple users.assays will be carried out. Current pathology labs are useddigital slide scanningscanner) enables fully automated screening of slides resulting in for service, a dedicated lab would allow for more lab timecapabilities (Onemore accurate images. It will enhance collaborative efforts between for research.Biotech)different research unit which involves Pathology. it will also allow Minor renovation, furnishing & maintenance.digital images to be sent for pathological review without necessarilysending off slides or having a pathologist on site. The PCRthermocycler and shaking incubator are for translational workinvolving transfections and identifications of over expressedproteins.10 Tissue arrayer 80,000 80,000 - 80,000 1 USAFull time, with visiting Professor Dr Anthony Roades11 Dessicator incupboard x 2Central Medical Genetics Lab :-40,000 40,000 - 40,000 1 USA12 384 well PCR200,000 200,000 - 200,000 1 USA Thermal cycler is for amplifying segments of DNA, cDNA via These items will complement the second generation sequencermachinethe polymerase chain reaction (PCR) process as well as that will be acquired for the Central Lab Facilities in Bagunan HIR.performing Taqman array screening.13 Real-time PCR 320,000 320,000 - 320,000 1 Switzerland Real-time PCR system provides a platform for the detection To conduct high throughput research studies in gene expression, Minor renovation, furnishing & maintenance.and quantification of nucleic acid sequences. It is an ideal mutation, and quantification. The existing facility is not enough tosystem for absolute quantification and allelic discrimination meet the requirement of the project.through Taqman or Invader chemistry screening.14 Liquid handler 100,000 100,000 - 100,000 1 USA Multi-channel automated pipettes are essential when Use of automated pipettors would also ensure consistent andperforming high throughput PCR or ELISA screening. A reproducible results in volume sensitive experiments such as ELISA,calibrated automatic pipettor would eliminate inconsistencies PCR, Taqman assay screening.due to human error.15 DNA extractor 150,000 150,000 - 150,000 1 USA Current systems utilize a cartridge format or column basedtechnology to extract DNA from all sorts of samples.Preloaded buffers would ensure consistency and good qualityDNA.16 freezers -20 & -80 150,000 150,000 - 150,000 1 Japan DNA, protein and RNA samples are heat sensitive and These 3 - tems are required for storage of blood and tissuedegrade easily without proper storage. As samples are scarce samples, and the computer servers are to store the 'data,and hard to come by, the freezers would be essential in particularly large datasets generated from the next generationmaintaining sample integrity, an important preceding step sequencing technology.towards high quality and reproducible results.Tracing and locating samples can be an ardous 17 Freezerworks - for50,000 50,000 - 50,000 1 USA task in the Automated extraction of DNA would greatly speed up otherwisearchiving samplesevent of a huge amount of samples. Hence an automated laborious task of extracting DNA. A walk away set up wouldsoftware for tagging and locating samples would enable swift increase productivity and maintain consistency.retrieval of samples and systematic archiving for long termstorage.18 Computer servers 230,000.00 230,000.00 - 230,000 1 Malaysia Myriad of data generated from Next generation sequencers, Needed for analysis of very high volume of data, tracking of records,DNA array screening machines requires a powerful computing monitoring work progress and generation of research outputs forsystem to screen and analyse data. Existing do not have the publication. This will be used continuously and will form a commonnecessary computing power to meet the requirements of facility for many researchers.whole genome screening approaches. Hence a localizedserver is needed.With these equipment, we hope to set up a MedicalGenetics Lab that will cater to all the researchgroups besides the HIR Breast Genetics Programmethat require genetic testing eg the colorectal cancergroup.These equipments will be used daily and fully utilisedwhen research is in progress. Other researchers fromother groups (molecular genetics, molecular biology,biochemistry etc) will find the facility useful too fortheir research.The usage is a permanent feature.Telomerase Research :-19 FISH microscope with350,000 350,000 - 350,000 1 Japan Measurement of telomere lengths These pieces of equipment are to bring telomerase research to Will be housed in research labs in the pathologyautomated XYZ stagemore frontline level as methodologies have changed.department. Software for analysis of probe distances will(stacker)(1) The FISH scope with stacker is essential as the new method for have to be acquired and will be unique to each project.telemere length determination involves fluorescent probes andThe FISH scope and spectrophotometer can support20 Spectrophotometer 40,000 40,000 - 40,000 1 Germany Telomerase detection and quantitationmeasuring distances between signals. The human hand is not ablemany other projects that use flourescent probes andto manuveur such fine distances without an automated stage. Alsoenzymatic assays. This can encourage many f uturenumerous images have to be captured which are too laborousMaster and Doctorate studies.without automation.(2) The spectrophotometer is essential in the "TRAP" enzymaticassay for telomerase detection and quantitation.21 Ultrapure (millipore)25,000 25,000 - 25,000 1 USAFull time, with 2 scientific officers.water filtrationsystem22 Refrigerated30,000 30,000 - 30,000 1 DenmarkcentrifugeEquipment for general molecular research23 Laminar flow cabinet 30,000 30,000 - 30,000 1Will be housed in research labs in the pathologyUK General use in molecular researchWill be a shared facility.department.- existing equipment are not economical to repair.24 Thermomixer 20,000 20,000 - 20,000 1 Germany25 Thermocycler (ABS) 30,000 30,000 - 30,000 1 USA3,616,500.00 3,000,000.00 0.00 3,000,000.00- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (CHANCELLORY)Estimated budgetApproved Budget (After VM Lab)Quantity Country ofJustification ofAdditional informationNo PI's Name Title EquipmentYear 2 & 3Details/unitoriginpurchase(space/utilities eg electric, software etc)(2012 & 2013 )2012 (RM) 2013 (RM) Total (RM)7 Dr. Faisal Rafiq Mahamd Integrated Photonics for 1 Low temperature45,000 45,000 - 45,000 1 UK A pyrometer is essentially a type of temperature sensor. It Our fibre drawing tower is the only one in South East Asia at the No additional space required. This item is small and will beAdikanBiosensorspyrometerwill be fitted into our optical fibre drawing tower to output moment. Equiping the tower with such pyrometer will extend its fitted to our furnace.temperatures ranging from 200 degrees celcius up to 2100 capability to operate on soft glasses and novel materials - highdegrees celcius.impact.2 Optical spectrum70,000 70,000 - 70,000 1 US/Japan Optical spectrum analysers provides wavelength information. Optical spectrum analysers are common test and measurement Benchtop. No additional space or facilities required.analyserThe basis of sensing in our project focuses on wavelength equipment in any optical laboratory.(IR wavelengthdynamics.region)3 Optical spectrum60,000 60,000 - 60,000 1 US/Japan Optical spectrum analysers provides wavelength information. Optical spectrum analysers are common test and measurement Benchtop. No additional space or facilities required.analyserThe basis of sensing in our project focuses on wavelength equipment in any optical laboratory.(UV wavelengthdynamics.region)4 Tunable laser source 75,000 75,000 - 75,000 1 US/Europe/ A laser source is complementary to a spectrum analyser. The Similar to optical spectrum analysers, tunable sources are common Benchtop. No additional space or facilities required.Japan wavelength emitted by the laser source will be detected by in any optical laboratory.the spectrum analyser.5 Clean room, wet200,000 - - 0 1 Local A clean environment and a support facility that would allow NO LONGER REQUIRED.N/A.bench and facilitiessurface functionalisation of sensor chips.We will rely on a central facility and sister laboratories.We wish to reallocated the budget to purchase items related toglass processing.6 High temperature50,000 - - 0 1 Japan/ Europe A box furnace for glass melting and shaping. NO LONGER REQUIRED.N/A.silicon carbideWe will rely on a central facility and sister laboratories.furnaceWe wish to reallocated the budget to purchase items related toglass processing.7 Various optics and50,000 50,000 - 50,000 numerous Local/ Europe/ US These include lenses, mirrors, mounts, drills, tool sets. The Important sundry items for operation of tower and alsoSmall items. No additional space or facilities required.mechanical toolsitems will find use either in our characterisation lab or the characterisation set up.fibre tower.8 Scopes and power100,000 - 100,000 100,000 numerous Local/ Europe/ US The oscilloscopes and power meters provide time, frequency Important test and measurement items for characterisation of Benchtop. No additional space or facilities required.metersand power measurement capabilities.fabricated sensors.9 Laser sources 35,000 - 35,000 35,000 1 US/ Europe/ A laser source is complementary to a spectrum analyser. The Similar to optical spectrum analysers, these laser sources are Benchtop. No additional space or facilities required.Japan wavelength emitted by the laser source will be detected by common in any optical laboratory.the spectrum analyser.10 Optical benches 50,000 - 50,000 50,000 1 US/ Europe/ A vibration insensitive bench, with necessary accessories. We anticipate that the laboratory will expand, and therefore the Typically measuring 1m by 2.5m. A room measuring 3mJapanneed for more workspace.by 3m would be needed. The space for needed has beenearmarked.11 Reserved for major75,000 - - 0 numerous Local/ Europe/ USequipment followingprogress of project12 Glass Processing- 205,650 - 205,650 Approved at the VM LABEquipmentsPotential users/research groupsFrequency and intensity of usage810,000.00 505,650.00 185,000.00 690,650.008Emeritus Prof. Dr. Lam SaiKitSpecial Equipments1 Femtosecond laser 1,300,000 1,300,000 - 1,300,000 1 Japan/USA Femtosecond laser is a standard laser system for Currently several groups in UM are actively doing research Lab space available in HIR Building.Photonics and ultrafast science researchers in Frequently used (5 days per week) and eachresearch at the frontier of laser science that can in the field called ultrafast laser science and femtosecond Meeting with architect, mechanical & electrical physics, chemistry and biology.experiment will run up few hours to 1 day.produce a pulse of photons that is shorter than a laser. Without this equipment we cannot conduct high engineer done. Software included.Optical physics, femtosecond laser groups.picosecond.precision measurements at and beyond current state of the A medium size (10'x10') instrument, needs air-cond Able to generate results for Tier 1 papers such asExperiments utilizing that technique it is useful to art. This will impede HIR work on femtosecond studies and and clean room which is available. Without this Nature Photonics, PNAS, Science, Nature, as perobserve atomic in molecular processes in chemical the HIR researchers will be unable to publish work in top Tier instrument, no femto-second research can proceed. thephotonics and femtosecond laser researchers asreactions in gases, liquids and solids, and also in 1 journals in this area. Physicists and chemists in UM need Experience researcher will be hired to manage thementioned.catalytic processes and biological materials. This laser this instrument to study reactions which no instruments are use of the equipment for research. The price wasAt least 10 PhD and 20 MSc students will be trainedwill provide new tool to create attosecond pulse able to detect. Exisitng femtosecond system was refurbished obtained from quotation by vendor.per PI using this instrument. This unit will enabletechnology for imaging electronic states. It is widely from an old one has poor and unreliable performance, with Frequently used (5 days per week) and eachUM to create niche area in whole genome research.used in quantum nonlinear optics, multiphoton restricted features such as limited power to conduct many experiment will run up few hours to 1 day.spectroscopy and microscopy (fluorescencenovel nonlinear optics experiments. Thus, we need state ofmicroscopes), micro-machining, femtochemistry, the art femtosecond laser in UM, since it is a bottleneck andmedical imaging Terahertz (T-rays) generation and hindering all related work in UMdetection and frequency comb generation.2 High performance400,000 400,000 - 400,000 1 USA This is a versatile system handles gel sandwiches, agarose and Bacause it has highly sensitive optics enable directIt is a table top size instrument and hence requires biologist, pharmacologist,Frequently used (5 days per week) and eachblot imagerpolyacrylamide gels, membranes, microplates, and even chemiluminescent imagingno big space at the HIR Building.molecular biologist, chemists working in imaging of experiment will run up few hours to 1 day.microarrays. It has red-, green-, and blue-excitation without intermediate exposure to films or screens. Moreover, it has Software is included.that needs storage phosphor technology. All userswavelengths and a wide choice of emission filters enable automated four-color fluorescence scanning allows multiplexing of Routinely and frequently used (5 days per week) that work on data imaging involvingimaging of an extensive variety of fluorophores and sensitive multiple targets in the same sample ensuring accuracy of analysis, and each usage will take few hours daily.bioluminescence, chemiluminescence, fluoresence.detection of low-abundance targets. Storage phosphor increasing throughput, and saving time. With this unit, manyThis is a peripheral yet essential instruments totechnology delivers high-resolution imaging and accurate blotting and hybridization work (Western, Souther, Nothern,support all other high throughput instruments thatquantitation of 3H, 14C, 125I, 32P, 33P, 35S, and other colony dot blot) can be done effortlessly and save time, chemicals,require massive blot imaging.sources of ionizing radiation.labour and fast delivery of results. This save time from few days tohour and enable speedy process for HIR research.3 Microarray withscanner, nanoprinter,software androbotics arm1,600,000 1,600,000 - 1,600,000 1 USA/Germany DNA microarrays can be used to detect DNA (as in Only one old unit available in UM which is old and not Lab space available in HIR Building. Meeting with Potential users include biologist, pharmacologist, Due to the autamated operation, this instrument cancomparative genomic hybridization), or detect RNA upgradable,architect, mechanical & electrical engineer done. molecular biologist, medical scientists. This is the be frequently used (5 days per week) and each usage(most commonly as cDNA after reverse transcription) and unable to fulfil current research needs. Microarray and Software included to analyse global gene expression instrument that can capture genes expression will take few hours to 1 day.that may or may not be translated into proteins. The scanner are required and it is now regarded as "routine" and quantitation of gene activity. A room size of regulation at spatio-temporal manner, and useful toprocess of measuring gene expression via cDNA is instrument in technologically advance labs. UM researchers 15'x15' with air-con.all users ranging from cancer studies, cell cycle, tocalled expression analysis or expression profiling. need this to study global genes expression and spatiotemporalgenes/genome expression is only possible with the can proceed.This is the instrument routinelyWithout this instrument, no genome expression work bacterial and viral genomic work.Applications on gene expression profiling, ChiP, SNPAble to generate results for Tier 1 papers such asdetection, genome expression profiling and comparative availability of this instrument. Microarray data have been available in Caltech, Imperial College, ParisNature, Science, PNAS, for all the users of thisgenomes, drug action mechanism, DAMID etc. accepted for publication in reputable Tier 1 journal such as University, Nottingham, London University, UCL,instrument as mentioned.Nature Genetics, Cell, PNAS etc.Cambridge etc.At least 5 PhD and 10 MSc students will be trainedDue to the autamated operation, this instrument canbe frequently used (5 days per week) and eachper PI using this instrument. This unit will enableusage will take few hours to 1 day.UM to create niche area in whole genome research.4 GS FLX+ NGS/pyrosequencer2,400,000 2,400,000 - 2,400,000 1 USA The GS FLX+ System is a pyrosequencer that has FLX+ NGS pyrosequencer is the latest unit in the market Lab space available in HIR Building.Target users including biologist, pharmacologist, Routinely and frequently used, and typical run lastssequence genomes in short time, with thewhich is released in Nov 2011. No such instruments Meeting with architect, mechanical & electrical molecular biologist, medical scientists studying for 10 days. It is anticipated that this instrument willcombination of long reads, exceptional accuracy and in UM/ South East Asia. UM researchers need it to perform engineer done. Genome sequences and gene whole genome, metagnome, transcriptome, exome, be heavily use as only 3-10 runs per month ishigh-throughput, making the system well suited for personalised genome sequencing, and plant, animal, annotation, analysis softwares are included. A room epigenetics sequencing, genes expression and possible.larger genomic projects. Advancements in sequencing bacteria whole genome sequencing can only be done using size of 13'x13' with air-con. Without this instrument, analysis. This is the instrument that can performchemistry, instrumentation and software offer the latest this instrument. This instrument since its invention few years no genome sequencing research can proceed. whole genome sequencing in less than 1 week. It isimprovements in GS FLX System performance, with back, it has made it to Nature, Science, J. Bacteriology, etc. Routinely and frequently used, and typical run lastsalso useful to all users ranging working on cancerread lengths up to 1 kb.for 10 days. It is anticipated that this instrument willstudies to microbial genomic work.be heavily use as only 3-10 runs per month isAt least 10 PhD and 20 MSc students will be trainedpossible.per PI using this instrument. This unit will enableUM to create niche area in whole genome research.- updated on 2nd March 2012 -

HIR-MOHE EQUIPMENT 2012 - 2013 (CHANCELLORY)No PI's Name Title Equipmentfluorescence5scanning forcemicroscope with ionchanneling platformEstimated budgetApproved Budget (After VM Lab)Quantity Country ofJustification ofAdditional informationYear 2 & 3DetailsPotential users/research groupsFrequency and intensity of usage/unitoriginpurchase(space/utilities eg electric, software etc)(2012 & 2013 )2012 (RM) 2013 (RM) Total (RM)1,500,000 1,500,000 - 1,500,000 1 Korea/USA Scanning force microscope is a high-resolution imaging This unit is measuring imaging at the atomic level, providing Lab space available in HIR Building.All researchers that requires high resolution imaging Frequently used (5 days per week) and eachtechnique that can resolve features as small as an unparallel resolution. It's now most commonly used to Meeting with architect, mechanical & electrical of large variety of surface material analysis for experiment will run up few hours to 1 day.atomic lattice in the real space. It allows researchers to perform very precise, 3D measurements on the angstrom-tomicrometerscale. It is needed for publications work that Without this instrument, no surface analysis and ion and engineers, and biologist.engineer done. Imaging software is included. material scienctists, advanced material researchersobserve and manipulate molecular and atomic levelfeatures.require visualisation as 'direct evidence' that is needed for movement research can proceed.Able to generate results for Tier 1 papers such asAtomic Force Microscopy has much broader potential Tier 1 publication. Without this instrument in UM,Frequently used (5 days per week) and each PNAS, Science, Nature, Nature Methods, Currentand application because it can be used for imaging any researchers can only outsourcing it to overseas partner, experiment will run up few hours to 1 day.Opinion in Structural Biology, as per the groups ofconducting or non-conducting surface.which are impractical and delaying results; or the work hasresearchers as mentioned.It provides the ability to view and understand events as been infinitely postponed. Also it is more economical inAt least 10 PhD and 20 MSc students will be trainedthey occur at the molecular level which will increase our terms of time and cost to own this.using this instrument. This unit will enable UM tounderstanding of how systems work and lead to newdiscoveries in many fields. These include life science,create niche area in whole genome research.materials science, electrochemistry, polymer science,biophysics, nanotechnology, and biotechnology6 Liquid handling400,000 400,000 - 400,000 1 USA It is fully automated platforms for liquid handling and Only one old unit available in UM which is old and not Lab space available in HIR Building.All researchers that requires highThis instrument will be heavily used on a daily basissystemfront-end sample processing and is designed for walkawayconvenience and reliability. The workstation and unable to fulfil current research needs. This is a routine engineer done. No software included. A small,requiring massive liquid handling.upgradable,Meeting with architect, mechanical & electrical throughput liquid handling platform.for researchers that needs to do research workfeatures several new innovations which ensure highprecisionpositioning and liquid transfer. The robotic man power, hence it will increase both productivity and laboratorius to do liquid handling work manually.instrument that typically require to reduce over-dependent on stand alone item. Without such instruments, it ishandling, automated vacuum, and buffer delivery efficiency.This instrument will be heavily used on a daily basissystems ensure high-performance processing withoutfor researchers that needs to do research workoperator interaction. It can handle 8-channel pipettingrequiring massive liquid handling. It also providessystem rapidly up to 384-well formats.support to other high throughput instruments likeMicroarray and NGS sequencers.7 QTOF GC-MS/MS 1,600,000 1,600,000 - 1,600,000 1 USA Q-TOF GC MS/MS is a powerful analytical chemistry This tandem gas chromatography mass spectrometry is Lab space available in HIR Building.Potential users typically involve chemist,Frequently used (5 days per week) and eachtechnique that is used to elucidate the structure needed by many research groups in UM working on volatile Meeting with architect, mechanical & electrical phytochemist,experiment will run up few hours to 1 day.and chemical properties of molecules and quantify trace compounds. Because no such instruments in UM, hence engineer done. Molecule mass identification and natural products scientists and pharmacist.levels of compounds in complex matrices notably the many research involving volatile fatty acids/compounds, database softwares are included.A room size of At least 5 PhD and 10 MSc students will be trainedvolatile ones. This is well-suited for analyzing target essential oils, pollutants (air/soild/liquid), toxins, small 22'x22' with air-con. Without this instrument, it is using this instrument.compounds and unknowns in challenging applications molecules have been suspended or interrupted at the impossible to do research on identification ofsuch as metabolomics, food safety, natural products molecular mass determination and molecule structure unknown, de novo compounds particularly thoseresearch, environmental analysis, sports-doping elucidation steps. LC-MSMS cannot perform similar function volatile that present in trace amount.detection, and energy researchas GC-MSMS.Many work reported in reputable journals includingJ. Bacteriology, Environmnetal Microbiology, AppliedEnviromental Microbiology, Nature Biotech relied onthis instrument for compound analysis.8 BIOLOG1,500,000 1,500,000 - 1,500,000 1 USA Phenotype MicroArrays (PMs) represent the third major No such instruments in UM although a much older version It is a table-top size instrument that bundled with a This is typically needed by biologist, pharmacologist,Phenotypetechnology, alongside DNA Microarrays and Proteomic has been bought in 1996. No software and hardware support workstation and requires a computer table. Lab microbiologist, medical scientists that studyMicroarrayTechnologies, that is needed in the genomic era of is given by the vendor for the old unit. The new unit can space is available in HIR Building.bacterial identification, carbon ultisation, and drugresearch and drug development. Just as DNAperform what has been routinely done i.e. microbialMeeting with architect, mechanical & electrical discovery.Microarrays and Proteomic Technologies have made it identification, it can also use for drug discovery. This unique engineer done. Bcaterial identification database and At least 10 PhD and 20 MSc students will be trainedpossible to assay the level of housands of genes or feature is vital to all researchers working on pharma-related softwares are included.A room size of 10'x10' with aircon.Without this instrument, no automated bacterialexperiment will run up few hours to 1 day.Frequently used (5 days per week) and eachper PI using this instrument.proteins all at once, Phenotype MicroArrays make it field, ranging from medical, pharmacy, pharmacology, naturalpossible to quantitatively measure thousands of cellular products, to clinical studies of drugs. It is an important for ID, phenomics and drug discovery research canphenotypes all at once. This instrument is important for microbiological work publishable in all Tier 1 microbiology proceed.drug discovery as well.papers including J. Bacteriology, Microbiology, AppliedEnvironmental Microbiology etc.9 Illumina HiSeq4,300,000 4,300,000 - 4,300,000It is important for high-density genotyping, CNV Unlike the other NGS sequencer including the FLX+ unit Lab space available in HIR Building.Target users including biologist, pharmacologist, Routinely and frequently used, and typical run lastsNGS/analysis,above, HiSeq is the single, most reported instruments that Meeting with architect, mechanical & electrical molecular biologist, medical scientists that requires for 10 days. It is anticipated that this instrument willpyrosequencerDNA methylation, and gene expression profiling. It is a authors in Nature, Science, PNAS, Cell, EMBO etc relied engineer done. Genome sequences and gene very high accuracy whole genome, metagnome, be heavily use as only 3-10 runs per month iscutting-edge, dedicated array scanner that supports upon. The sequence read length though is shorter, but it has annotation, analysis softwares are included. A room transcriptome, exome, epigenetics sequencing. possible.rapid, sensitive, and accurate imaging of Illumina's a higher accuracy (>98%) as compared to other NGS size of 13'x13' with air-con. Without this instrument, At least 10 PhD and 20 MSc students will be trainedarray-based genetic analysis products.sequencer. Because there is no such instruments in UM, no genome sequencing research can proceed. per PI using this instrument. This unit will enablemany genome studies have been crompromised or very A full operation of this instrument will run for 10 daysUM to create niche area in whole genome research.1 USAcostly to out-source, which is also troublesome to maintain although routine use will take only 1-5 days. It isthe data quality as this is a comprehensive sequencing anticipated that this instrument will complement theplatform.FLX+ instrument to generate tera bases of DNAfrom whole genome of plant and animal. Mostgenome work can be published in Nature, Science,PNAS, J. Bacteriology, BMC Genomics, PLoSBiology; which have relied heavily on HiSeq.10 PacBio SingleMolecule Real timeSynthesis (SMRT)Instrument11 ultrasensitive highthroughputthermodynamiccalorimeter12 Fully IntegratedWorkstationsolution system3,500,000 3,500,000 - 3,500,0001 USA800,000 800,000 - 800,0001 USA948,000 948,000 - 948,000 1 USA/GermanyIt is important for animal, plant and bacteria whole The power of single molecule, real-time, (SMRT) detection Lab space available in HIR Building.Target users including bioinformaticians, system Routinely and frequently used, and typical run lastsgenome sequences, high-density genotyping, SNP extends beyond DNA sequencing to the detection and Meeting with architect, mechanical & electrical biologist, bacteriologist, virologits, molecular for 5 hours. It is anticipated that this instrument willanalysis,characterization of other fundamental biological functions. engineer done. Genome sequences and gene biologist, medical scientists that requires very high be heavily used on a daily.epigenetics and global genes expression profiling. It is SMRT platform will define a new paradigm in biological annotation, analysis softwares are included. A room accuracy whole genome data.latest of its kind, providing a cutting-edge, dedicated science that we refer to as SMRT Biology. The ability of the size of 12'x12' with air-con. A typical sequencing run At least 15 PhD and 25 MSc students will be trainedsequencing that supports all genomic-related analysis. SMRT technology to observe kinetic information of individual can require as little as 30 minutes of instrument per PI using this instrument. This unit will enablemolecules provides the ability to detect nucleic acid time. Sequence data is produced in minutes ratherUM to create niche area in single molecule, realvariations, including detection of base modifications and the than days, potentially enabling importanttime (SMRT) which is currently the latest technologydetection of binding of biomolecules to DNA. SMRT applications including infectious disease monitoringin USA and whole genome research.detection has been applied by researchers to directly and molecular pathology.At least 10 PhD and 20 MSc students will be trainedobserve, on a single molecule basis, transcription, reverse Most genome work can be published in Nature,transcription, translation and ligand-protein binding. Science, PNAS, J. Bacteriology, BMC Genomics,per PI using this instrument. This unit will enablePLoS Biology.UM to create niche area in whole genome research.It is a gold technique that directly measures heat This A wide is the range 3rd of genaration applications sequencer can only that be accomplished replies on single with This instrument is slightly larger than table-top size, Drug discovery groups in UM, pharmacist, natural Frequently used (5 days per week) and eachchanges associated with binding between any two this unit including:and lab space is available in HIR Building.products chemists & biologist, microbiologist, experiment will run up few hours to 1 day.biomolecules. This instrument is the latest advance in characterization of molecular interactions of small molecules, Meeting with architect, mechanical & electrical biochemist, cancer/clinical oncologist group, proteinisothermal titration calorimetery, which is designed for proteins, antibodies, nucleic acids, lipids and otherengineer done. Analysis softwares are included. A engineering groups.cutting edge life science researchers – particularly biomolecules, enzyme kinetics, assessing the effects of room size of 13'x13' with air-con. Without this At least 3 PhD and 10 MSc students will be trainedthose in drug discovery and development.molecular structure changes on binding mechanisms, and instrument, no interaction of biomolecules studies per PI using this instrument.It has a highthroughput capacity to handle multiple biotherapeutic construct selection. Hence, the availability of can proceed.samples rather than a single sample analysis.this unit will benefit research groups that need to measure in Many work reported in reputable journals includingprecision the free energy changes and sub-millimolar to J. Bacteriology, J. Biol. Chemistry, Biochemistry,nanomolar binding constants that can be measured by this Nature Biotech relied on this instrument forinstrument.compound analysis.This is a fully integrated computing solution for This system can keep pace with the remarkable growth in With this system, researchers can keep pace with Target users including bioinformaticians, systemgenome analyzer sequencing platforms detailed the throughput of the genome analyzer. Without it, individual changes to their computing needs with virtually no biologist, bacteriologist, physicists, computer/ITabove. It is a powerful sequencing software with users have to acquire the workstation and the related system down-time. It will bundle with hardware, specialists, virologits, molecular biologist, medicalhigh-performance blade servers/workstation and software indivually, which is not economically viable. informatics software and high-availability storage. scientists, pharmacologists, pharmarcists,modular storage capacity. This creates a flexible Depending on the needs of HIR Central users in the future, This system is planned specifically for a medium to oncologists, translational health and medicineand scalable system for higher organismsthis proposed solution system can be customized and high-throughput sequence analysis workflow. Server researchers, who require genome data processsing,extended for small and growing sequencing facilities and also and disk management overhead is kept to anincluding human scale genomic data analysis.analysis, and storage.scaled to meet the needs of larger genome center.absolute minimum, reducing the need for dedicatedThe new solution conserves IT resources byAt least 15 PhD and 30 MSc students will be trainedIt provides sufficient processing resources for computationalheavyanalysis that requires clustered processing and typically publish in Nature, Science, PNAS, J.24 hr per day on daily basis.IT and bioinformatics staff. Most genome workWorkstation analysis and data storage usually run forproviding centralized high-performanceper PI using this instrument. This unit will enablecomputational and storage infrastructure,UM to create niche area in single molecule, realshared data repositories, such as genome assembly, deep Bacteriology, BMC Genomics, PLoS Biology.compared to the support required for individual,sequencing and metagenomics research.time (SMRT) which is currently the latest technologydecentralized analysis servers.in USA and whole genome research.At least 10 PhD and 20 MSc students will be trainedper PI using this instrument. This unit will enableUM to create niche area in whole genome research.20,248,000.00 20,248,000.00 0.00 20,248,000.00Total 37,896,500.00 36,405,650.00 755,000.00 37,160,650.00 97Rejected at VM LabApproved at VM Lab- updated on 2nd March 2012 -