PAS x40 - RCPA

Quantitative criteria for mesangial matrixincrease (mm)* score:mm0 no mesangial matrix increasemm1 up to 25% of non-sclerotic glomeruli affected (at leastmoderate matrix increase)mm2 26-50% of non-sclerotic glomeruli affected (at leastmoderate matrix increase)mm3 >50% of non-sclerotic glomeruli affected (at least moderatematrix increase)* the threshold criterion for the moderately increased ‘mm’ is theexpanded mesangial interspace between adjacent capillaries; if thewidth of the interspace exceeds two mesangial cells on average inat least two glomerular lobules, the ‘mm’ is moderately increased