Glucagon-Like Peptide-1 (GLP-1)
Glucagon-Like Peptide-1 (GLP-1)
Glucagon-Like Peptide-1 (GLP-1)
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The <strong>GLP</strong>-1 receptor is a G-proteincoupled receptor (GPCR)The <strong>GLP</strong>-1R is a G-protein coupled receptor(GPCR) of the Gs-subtypeJi T H et al. J. Biol. Chem. 1998;273:17299-17302Pierce et al.Nature Reviews 2002 Molecular Cell Biology 3, 639-650Liraglutide binding to the N-terminus ofthe <strong>GLP</strong>-1 receptorInteraction of liraglutide with the fulllength<strong>GLP</strong>-1 receptorBased on: Runge et al, J.Biol.Chem. 2008;283(17):11340-11347Based on: Runge et al, J.Biol.Chem. 2008;283(17):11340-11347<strong>GLP</strong>-1 induced intracellular signaling andinsulin secretion in the pancreatic β-cell<strong>GLP</strong>-1 increases β-cell mass throughproliferation, apoptosis and neogenesisDoyle et al., Pharmacology & Therapeutics 2007;113:546-593Doyle et al., Pharmacology & Therapeutics 2007;113:546-593
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