Yamazaki, M., Chiba, K., Mohri, T., and Hatanaka, H. (2001). Activation <strong>of</strong> the mitogen-activated prote<strong>in</strong> k<strong>in</strong>ase cascade through nitric oxide synthesis as a mechanism <strong>of</strong> neuritogenic effect <strong>of</strong> genip<strong>in</strong> <strong>in</strong> PC12h cells. J. Neurochem 79, 45-54. Yoshihara, Y., De Roo, M., and Muller, D. (2009). Dendritic sp<strong>in</strong>e formation and stabilization. Curr. Op<strong>in</strong>. Neurobiol 19, 146-153. Young, D. V., Serebryanik, D., Janero, D. R., and Tam, S. W. (2000). Suppression <strong>of</strong> proliferation <strong>of</strong> human coronary artery smooth muscle cells by the nitric oxide donor, Snitrosoglutathione, is cGMP-<strong>in</strong>dependent. Mol. Cell Biol. Res. Commun 4, 32-36. Yue, X., Dreyfus, C., Kong, T. A., and Zhou, R. (2008). A subset <strong>of</strong> signal transduction pathways is required for hippocampal growth cone collapse <strong>in</strong>duced by ephr<strong>in</strong>-A5. Dev Neurobiol 68, 1269-1286. Zhang, P., Liu, Y., Li, J., Kang, Q., Tian, Y., Chen, X., Zhao, J., Shi, Q., and Song, T. (2007). Decreased neuronal nitric oxide synthase expression and cell migration <strong>in</strong> the peri-<strong>in</strong>farction after focal cerebral ischemia <strong>in</strong> rats. Neuropathology 27, 347-354. Zhang, R., Zhang, L., Zhang, Z., Wang, Y., Lu, M., Lapo<strong>in</strong>te, M., and Chopp, M. (2001). A nitric oxide donor <strong>in</strong>duces neurogenesis and reduces functional deficits after stroke <strong>in</strong> rats. Ann. Neurol 50, 602-611. Zhou, L., and Zhu, D. (2009a). Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and cl<strong>in</strong>ical implications. <strong>Nitric</strong> <strong>Oxide</strong> 20, 223-230. Zhou, L., and Zhu, D. (2009b). Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and cl<strong>in</strong>ical implications. <strong>Nitric</strong> <strong>Oxide</strong> 20, 223-230. Zhu, D. Y., Liu, S. H., Sun, H. S., and Lu, Y. M. (2003). Expression <strong>of</strong> <strong>in</strong>ducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis <strong>in</strong> the adult rodent dentate gyrus. J. Neurosci 23, 223-229. Zhu, X. J., Hua, Y., Jiang, J., Zhou, Q. G., Luo, C. X., Han, X., Lu, Y. M., and Zhu, D. Y. (2006). Neuronal nitric oxide synthase-derived nitric oxide <strong>in</strong>hibits neurogenesis <strong>in</strong> the adult dentate gyrus by down-regulat<strong>in</strong>g cyclic AMP response element b<strong>in</strong>d<strong>in</strong>g prote<strong>in</strong> phosphorylation. Neuroscience 141, 827-836. Zulauf, L., Coste, O., Marian, C., Möser, C., Brenneis, C., Niederberger, E. (2009). C<strong>of</strong>il<strong>in</strong> phosphorylation is <strong>in</strong>volved <strong>in</strong> nitric oxide/cGMP-mediated nociception. Biochem. Biophys. Res. Commun 390, 1408-1413. 29
Acknowledgments I thank my supervisor Pr<strong>of</strong>. Dr. Gerd Bicker for allow<strong>in</strong>g me to work <strong>in</strong> an excit<strong>in</strong>g project and for his excellent guidance throughout my PhD project. Dur<strong>in</strong>g my stay <strong>in</strong> your laboratory I have learned not only how to become a good researcher but also a mentor. Thank you very much! I also extend my s<strong>in</strong>cere gratitude to my advisory group Pr<strong>of</strong>. Dr. Stephan Ste<strong>in</strong>lechner and Pr<strong>of</strong>. Dr. Herbert Hildebrandt for the useful discussion, suggestion and guidance throughout my doctoral process. I thank Pr<strong>of</strong>. Dr.med. Ellen Fritsche and Dr. Thomas D<strong>in</strong>o Rockel (Group <strong>of</strong> Molecular Toxicology, Institut für Umweltmediz<strong>in</strong>ische Forschung, He<strong>in</strong>rich He<strong>in</strong>e-University, Dusseldorf, Germany) for permitt<strong>in</strong>g me to work on fetal human neural progenitor cells and cont<strong>in</strong>uous collaboration throughout this project. I thank ZSN PhD commission specially Pr<strong>of</strong>. Dr. Wolfgang Löscher, Pr<strong>of</strong>. Dr. Wolfgang Baumgartner and the coord<strong>in</strong>ation <strong>of</strong>fice (Dr. Dagmar Esser, Nadja Borsum and Manuela Chambers) for cont<strong>in</strong>uous support throught my doctoral study. I also s<strong>in</strong>cerely thank the M<strong>in</strong>istry for Science and Culture <strong>of</strong> Lower Saxony for giv<strong>in</strong>g me the Georg-Christoph-Lichtenberg scholarship throughout my PhD study. My stay <strong>in</strong> cell biology group could not be as fruitful as it is without the support and pleasant environment created by present and past colleagues <strong>in</strong> the lab. I thank Dr. Micheal Stern for his constructive comments, suggestion and discussion. I thank Saime Tan for her excellent technical support. I am also thankful to Dr. Sab<strong>in</strong>e Knipp and Dr. Grzegorz Podrygajlo for useful discussion. My thanks also go to Arne Pätschke, Andrea Gierse, Rene Eickh<strong>of</strong>f, Nicole Böger, Frank Rol<strong>of</strong>f and Christ<strong>in</strong>a Lorbeer. Last but not least I thank my family; Lydia and Betania. Thank you very much Lydia for the love, courage and support you gave me throughout this work. Betu you helped a lot by stay<strong>in</strong>g long <strong>in</strong> the k<strong>in</strong>dergarten. Thank you for your patience. 30
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