Nitric Oxide Mediated Signal Transduction in Networks of Human ...

Table of content
1. Introduction 1
1.1. Nitric oxide signal transduction 1
1.1.1. Discovery of NO 1
1.1.2. Synthesis of NO and activation of downstream effectors 1
1.2. NO and early stages of CNS development 3
1.2.1. Neuronal precursor proliferation 3
1.2.2. Neuronal migration 4
1.2.3. Neuronal differentiation 5
1.2.4. Synaptogenesis 6
1.3. NO and adult neurogenesis 7
1.4. NO signaling in neurodegenerative diseases 8
1.5. Human neuronal stem cells as a model of developing nerve cells 9
1.6. Hypothesis and aim of the study 11
2. Discussion 12
2.1. Nitric oxide and cGMP signal transduction positively regulates
the motility of human neuronal precursor (NT2) cells 12
2.2. Nitric oxide and cyclic nucleotide signal transduction modulates
synaptic vesicle turnover in human model neurons 13
2.3. Nitric oxide signaling as regulator of human neuronal progenitor cell migration 16
References 18
Acknowledgments 30
Summary 31
Zusammenfassung 33
3. Publications
3.1. Nitric oxide and cGMP signal transduction positively regulates the motility of human
neuronal precursor (NT2) cells, Tegenge M.A. and Bicker G. (2009), J. Neurochem. 110, 1828-1841.
3.2. Nitric oxide and cyclic nucleotide signal transduction modulates synaptic vesicle turnover in
human model neurons, Tegenge M.A. et al. (2009), J. Neurochem. 111, 1434-1446.
3.3. Nitric oxide signaling as regulator of human neuronal progenitor cell migration,
Tegenge M.A. et al. (In preparation).