Fine Lines, Wrinkles & Texture Research Update - P&G Beauty ...

Effect Of Niacinamide On Increase In Collagen Synthesis In Human Dermal Fibroblasts
particular, niacinamide supplementation
has been shown to stimulate
collagen synthesis in human dermal
fi broblasts, 47 an eff ect that would be
of particular signifi cance in aged and
photodamaged skin.
Multiple clinical studies have demonstrated
the positive eff ects of niacinamide-containing
moisturizers on the
appearance of wrinkles and fi ne lines
in aging skin. 29, 48 In one, 29 a 12-week
randomized, split-face trial, 50 female
subjects applied blind-coded product
Total protein Total collagen
Collagen: total
protein ratio
500uM niacinamide 41% 54% 35%
These data demonstrate that niacinamide treatment has a positive effect on collagen production relative to
control and that there is specifi city for collagen biosynthesis and secretion relative to other cellular proteins.
BETTER
Change in fine lines/wrinkles area vs. baseline
5.00 –
0.00 –
-5.00 –
-10.00 –
-15.00 –
-20.00
followed by image analysis. Signifi cant
improvements were seen in several
facial parameters including appearance
of fi ne lines and wrinkles (p=0.06 at
week 8 and 0.0005 at week 12).
In another study, 40 female subjects
applied blind-coded products in a
split-face design for 12 weeks. Significant
improvements in skin texture
including fi ne line appearance were
observed in niacinamide-treated skin
at both four and 12 weeks of treatment
(p