New insights into the management of severe sepsis and septic shock

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Early haemodynamic optimization(resuscitation bundle) During the first 6 hours in the ED, the earlygoal-directed therapy group had significantlygreater amount of fluid therapy than thecontrol group (5.0 versus 3.5 L, respectively),RBC transfusion (64.1% versus 18.5%,respectively), and inotrope (ie, dobutamine)administration (13.7% versus 0.8%,respectively). The primary outcome variable, inhospitalmortality rate, was 46.5% in the control groupversus 30.5% in the early goal-directed therapygroup
Early haemodynamic optimization(resuscitation bundle)Subsequent studies over one decade Validated the RB and its elements Provided evidence that this therapy modulatesinflammation and decrease organ failureprogression Showed that this approach consistently saves 1out of every 6 lives presenting with severesepsis/septic shockCurrent guidelines continue to recommend EGDTpending the results of numerous ongoing trials
Page 1 and 2: Surviving Sepsis Campaign UpdatedGu
Page 3 and 4: Guide to Recommendations’ Strengt
Page 5 and 6: Definitions Severe sepsis is define
Page 7: Prognosis More than half of all sep
Page 10 and 11: Early haemodynamic optimization(res
Page 14 and 15: Components of EGDT(resuscitation bu
Page 16 and 17: Surviving Sepsis: New monitoringrec
Page 18 and 19: Surviving Sepsis: New Fluid Resusci
Page 20 and 21: Surviving Sepsis: New Recommendatio
Page 22 and 23: Inotropic therapy After adequate vo
Page 24 and 25: Decreasing oxygen consumption When
Page 27 and 28: Empirical antibiotic combinations P
Page 29 and 30: Source controlMeasures to eradicate
Page 31 and 32: Drotrecogin alfa (activated protein
Page 33 and 34: Systemic corticosteroids Despite mo
Page 35 and 36: Systemic corticosteroidsSumming up,
Page 37: Surviving Sepsis guidelines regardi

New insights into the management of severe sepsis and septic shock

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