New insights into the management of severe sepsis and septic shock

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Decreasing oxygen consumption When ScvO2 remain less than 70% after theCVP, arterial BP and haematocrit havereached the target, oxygen consumptioncan be reduced through mechanicalventilation to decrease the work ofbreathing and redistribute blood flow tovital organs
Antimicrobial therapy Administration of antibiotics within the timeof ED care and as soon as possible oncethere is a reasonable suspicion of severesepsis is likely to increase the chance offavourable outcome compared with lateradministration (Grade E) Empirical regimens should be sufficientlybroad, so there is little chance (less than5%) that the offending pathogen will not beeffectively covered
Page 1 and 2: Surviving Sepsis Campaign UpdatedGu
Page 3 and 4: Guide to Recommendations’ Strengt
Page 5 and 6: Definitions Severe sepsis is define
Page 7: Prognosis More than half of all sep
Page 10 and 11: Early haemodynamic optimization(res
Page 12 and 13: Early haemodynamic optimization(res
Page 14 and 15: Components of EGDT(resuscitation bu
Page 16 and 17: Surviving Sepsis: New monitoringrec
Page 18 and 19: Surviving Sepsis: New Fluid Resusci
Page 20 and 21: Surviving Sepsis: New Recommendatio
Page 22 and 23: Inotropic therapy After adequate vo
Page 27 and 28: Empirical antibiotic combinations P
Page 29 and 30: Source controlMeasures to eradicate
Page 31 and 32: Drotrecogin alfa (activated protein
Page 33 and 34: Systemic corticosteroids Despite mo
Page 35 and 36: Systemic corticosteroidsSumming up,
Page 37: Surviving Sepsis guidelines regardi

New insights into the management of severe sepsis and septic shock

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