New insights into the management of severe sepsis and septic shock

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Inotropic therapy After adequate volume, mean arterial pressure,and hematocrit goals are met and ScvO2 ispersistently less than 70%, dobutamine toimprove contractility, in a dosage of 2.5 to 20µg/kg/minute, titrated to achieve ScvO2greater than 70%, is recommended. Because the vasodilatory effect of dobutaminecould worsen hypotension, it should be used incombination with vasopressors for patientswith persistent hypotension.
Surviving Sepsis: New Recommendationsfor inotropic therapy Dobutamine is strongly recommended (byitself or in addition to a vasopressor) forpatients with:1. cardiac dysfunction as evidenced by highfilling pressures and low cardiac output, or2. clinical signs of hypoperfusion afterachievement of restoration of bloodpressure with effective volumeresuscitation (Grade 1C).
Page 1 and 2: Surviving Sepsis Campaign UpdatedGu
Page 3 and 4: Guide to Recommendations’ Strengt
Page 5 and 6: Definitions Severe sepsis is define
Page 7: Prognosis More than half of all sep
Page 10 and 11: Early haemodynamic optimization(res
Page 12 and 13: Early haemodynamic optimization(res
Page 14 and 15: Components of EGDT(resuscitation bu
Page 16 and 17: Surviving Sepsis: New monitoringrec
Page 18 and 19: Surviving Sepsis: New Fluid Resusci
Page 20 and 21: Surviving Sepsis: New Recommendatio
Page 24 and 25: Decreasing oxygen consumption When
Page 27 and 28: Empirical antibiotic combinations P
Page 29 and 30: Source controlMeasures to eradicate
Page 31 and 32: Drotrecogin alfa (activated protein
Page 33 and 34: Systemic corticosteroids Despite mo
Page 35 and 36: Systemic corticosteroidsSumming up,
Page 37: Surviving Sepsis guidelines regardi

New insights into the management of severe sepsis and septic shock

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