New insights into the management of severe sepsis and septic shock

Volume therapy The first parameter to target in hemodynamicoptimization is intravascular volume with theuse of fluid therapy targeting a central venouspressure of 8 to 12 mm Hg. No outcome benefit has been demonstrated inusing colloids compared to crystalloids withrespect to mortality or hospital length of stay. However, in one investigation a trend toimproved survival with the use of colloid(albumin) in sepsis was observed