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Title of DissertationTABLE OF CONTENTSPAGEDedication 11CertificationiiiAcknowledgementAbbreviationsTable of ContentsListofTablesListof FiguresAbstractIVVIIxXVIxviuXIX-CHAPTER ONE 11.1 Introduction I1.2 Aims and objectives 221..2.1 Specific objectives 2';':i,~ , CHAPTER TWO 32.0 Review of Literature 32.1 Historical Review ofFlavivirus Infections 32.1.1 TheOrigin of Flaviviruses 32.2 The family Flaviviridae 62.2. I Flaviviruses 62.2.2. Morphology of Flaviviruses 72.2.2.3. Physical and chemical properties of Flaviviruses 72.2.4 Genome Organization ofFlaviviruses 92.2.5 Structural Proteins ofFlaviviruses 102.2.5.1 The C Protein 102.2.5.2 The prM and M Proteins 102.2.5.3 The E protein 112,2.5.4 NonstructuraI Proteins ofFlaviviruses 122,2.5.4.1 The NS3 Protein 132.2.5.4.2 The NS5 Protein 14X