Chromosome - Fapesp
Chromosome - Fapesp
Chromosome - Fapesp
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ACE & Cellulosic Butanol<br />
C. thermocellum<br />
Cellulosome<br />
C. acetobutylicum<br />
Cellulosic clostridia make ethanol, not<br />
butanol<br />
They produce a ‘Cellulosome’:- a<br />
molecular nanomachine – very efficient<br />
in degrading lignocellulose<br />
The core of the complex is a modular,<br />
non-catalytic scaffoldin protein which<br />
serves to bring enzymes into close<br />
proximity via cohesin-dockerin<br />
interactions, enhance enzyme activity<br />
We seek to introduce a functional<br />
cellulosome into the genome of a noncellulolytic<br />
butanol producer using<br />
ACE technology
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