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Collaborative Intravenous Nursing Service (CINS) Guidelines

Collaborative Intravenous Nursing Service (CINS) Guidelines

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15Appendix 1CLASSIFICATION OF CYTOTOXIC DRUGS ACCORDING TO THEIR POTENTIAL TO CAUSE SEVERENECROSIS WHEN EXTRAVASATEDVesicants:Group 1Exfoliants:Group 2Irritants:Group 3Inflammitants:Group 4Amsacrine Aclarubicin Carboplatin EtoposideCarmustine Cisplatin (concDacarbazine>0.5mg/ml)DaunorubicinLiposomalPhosphateNeutrals:Group 5(unlikely tocause problemsif extravasated)AsparaginaseEtoposide Fluorouracil BleomycinIrinotecan Methotrexate CladribineDactinomycin Docetaxel Teniposide Raltitrexed CyclophosphamiDaunorubicinDoxorubicinLiposomaldeCytarabineDoxorubicin Floxuridine bortezomibEpirubicin Oxaliplatin FludarabineIdarubicin Topotecan GemcitabineMitomycinMitoxantroneMustinePaclitaxelPlicamycinIfosfamideMelphalanPentostatinRituximabThiotepaBeta-InterferonsStreptozocin Aldesleukin (IL-TreosulfanVinblastineVincristineVindesineVinorelbine2)TrastuzumabcisplatinalemtuzumabNb this list may not be exhaustive. It is the practitioners responsibility to know the vesicant potential of any drugnot on this list Appendix 2The CINs group hereby assert their moral rights tothe works herein in accordance with the Data Protection Act 1988.Policy review date 01/10/10

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