Pharmacokinetics Language English Format: PDF Price - Tutorsindia

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<strong>Pharmacokinetics</strong>Additional material available from the internetAnswers to practice questionsChapter 31.Target concentration = midrange value = 200 μg/LPredicted V = 0.72 L/Kg x 65 Kg= 46.8 LD = C x V= 200μg/L x 46.8L= 9,360 μg= 9.4 mg2.Predicted V = 0.91L/Kg x 80Kg= 72.8LC = D / V= 5mg / 72.8L= 0.069 mg/L (Remember 1mg = 1000μg)= 69 μg/LUnsatisfactory – the dose is excessive.3.V = D / C= 200μg / 12.5ng/mL (Mixed mass units need to be adjusted)= 200μg / 12.5μg/L= 16L4.C = (D x S) / V= (5mg x 0.7) / 70L= 3.5mg / 70L= 0.05mg/L= 0.05 μg/mL= 50 ng/mL(Note Salt factor is included to reduce the calculated concentration)134Download free ebooks at bookboon.com
<strong>Pharmacokinetics</strong>Additional material available from the internet5.V = D / C= 0.5mg / 20ng/mL (Mixed mass units to be adjusted)= 500μg / 20μg/L= 25L6.Target concentration = midrange value = 550ng/mLPredicted V = 0.45L/Kg x 70Kg= 31.5LD = C x V= 550ng/mL x 31.5L (Mixed volume units to be adjusted)= 550μg/L x 31.5L= 17,325μg(Increasing the dose to allow for the salt factor …)Dose = 17,325μg / 0.75= 23,100μg= 23.1mgChapter 41.T_half = 0.693 / K= 0.693 / 0.0131h -1= 52.9 hours2.Cl = Q Hx E= 1.2 L/min x 0.04= 0.048 L/min= 0.048 x 60 L/h= 2.88 L/h3.K = 0.693 / 12h= 0.058 h -1Download free ebooks at bookboon.com135
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