Pharmacokinetics Language English Format: PDF Price - Tutorsindia

More documents

Recommendations

Info

<strong>Pharmacokinetics</strong>Distribution: Compartments and Volume of DistributionThe volume of distribution reflects the tendency of a drug to distribute out of the blood into the tissues. A largevolume implies a strong tendency to distribute into the tissues.BloodTissues(a)Stays mainly in blood.(b)Distributes evenly.(c)Distributes stronglyinto tissue.Figure 3.10 The spectrum of possible patterns of distribution for a drug.The generation of a numerical value for V is explained via Figure 3.11.Please click the advert32Download free ebooks at bookboon.com
<strong>Pharmacokinetics</strong>Distribution: Compartments and Volume of DistributionDVC = D/VV = D/CFigure 3.11 The relationship between drug dose, volume and concentration for a bottle or a patientStart with something simpler than the human body - a bottle. The bottle in Figure 3.11 has a volume of V litres and a dose(D mg) of drug is added and allowed to dissolve and disperse evenly throughout the volume. The resultant concentration(C; in mg/L) will be:C = D/VIn an alternative scenario, we might not know the volume of the bottle, but we could determine this by adding a knowndose of drug, stirring and then removing a sample for analysis, to determine drug concentration. We then calculate thevolume by re-arranging the previous formula:V = D/CWe can perform a similar operation in a patient – inject a known dose of drug, remove a blood sample to determinedrug concentration and finally obtain a volume by the same calculation. The value we would obtain by this calculationis the volume of distribution for the drug. A simple example is shown in Figure 3.12. It doesn’t matter whether the dose(50mg) was delivered into a bottle or a patient or whether the resultant concentration (0.25 mg/L) describes a laboratorysolution or a patient’s blood sample. Either way the relevant volume is 200 Litres.DVD = 50 mgC = 0.25 mg/LV = D/C= 50mg / 0.25mg/L= 200 LitresFigure 3.12 A simple example of the relationship between drug dose, concentration and volume for a bottle or a patient33Download free ebooks at bookboon.com
Page 2 and 3: Philip RowePharmacokineticsDownload
Page 4 and 5: PharmacokineticsContentsContentsInt
Page 6 and 7: PharmacokineticsContents7.3 Determi
Page 8 and 9: PharmacokineticsContents13 Computer
Page 10 and 11: PharmacokineticsADME and Pharmacoki
Page 12 and 13: PharmacokineticsADME and Pharmacoki
Page 14 and 15: PharmacokineticsAbsorption: Absorpt
Page 24 and 25: PharmacokineticsDistribution: Compa
Page 38 and 39: PharmacokineticsElimination: Elimin
Page 48 and 49: PharmacokineticsSingle intravenous
Page 56 and 57: PharmacokineticsAnalysis of experim
Page 74 and 75: PharmacokineticsConstant intravenou
Page 82 and 83:
PharmacokineticsConstant intravenou
Page 84 and 85:
PharmacokineticsExtravascular admin
Page 86 and 87:
Page 88 and 89:
Page 90 and 91:
Page 92 and 93:
Page 94 and 95:
PharmacokineticsMultiple dosing10 M
Page 96 and 97:
PharmacokineticsMultiple dosing1614
Page 98 and 99:
PharmacokineticsMultiple dosingIn c
Page 100 and 101:
PharmacokineticsMultiple dosingCss,
Page 102 and 103:
PharmacokineticsMultiple dosing1614
Page 104 and 105:
PharmacokineticsMultiple dosing10.6
Page 106 and 107:
PharmacokineticsMultiple dosing76Co
Page 108 and 109:
PharmacokineticsMultiple dosing5. A
Page 110 and 111:
PharmacokineticsNon-linear pharmaco
Page 112 and 113:
Page 114 and 115:
Page 116 and 117:
PharmacokineticsNon-compartmental p
Page 118 and 119:
PharmacokineticsNon-compartmental p
Page 120 and 121:
PharmacokineticsComputerized analys
Page 122 and 123:
Page 124 and 125:
Page 126 and 127:
PharmacokineticsCreatinine clearanc
Page 128 and 129:
PharmacokineticsCreatinine clearanc
Page 130 and 131:
PharmacokineticsPharmacokinetic sym
Page 132 and 133:
PharmacokineticsPharmacokinetic sym
Page 134 and 135:
PharmacokineticsAdditional material
Page 136 and 137:
Page 138 and 139:
Page 140 and 141:
Page 142 and 143:
Page 144 and 145:
Page 146 and 147:
show all

Pharmacokinetics Language English Format: PDF Price - Tutorsindia

Create successful ePaper yourself

Delete template?

Save as template?