Pharmacokinetics Language English Format: PDF Price - Tutorsindia

PharmacokineticsAnalysis of experimental data...Time (h)Concentration (ng/mL)4 1528 12814 7420 4428 24Table 6.2 Drug concentrations at various times following 15mg i.v. bolus injectionUse the sheet of blank semi-log graph paper (Next page) to plot the data, fit a line by eye and calculate V, K and clearance.The Practice calculations section in Chapter 13 (Section 13.2) invites you to re-analyse the data using a computerizedapproach.2) A patient received a dose of 120mg of drug by bolus i.v. injection. Blood samples were taken at 2 and 12hours post dosing and found to contain 7.1 and 0.8mg/L of drug respectively. Using formulae only (not agraph) calculate K and V for this patient.3) Repeat the calculation of question 2, using the spreadsheet available from www.phrData.co.uk. Click‘Pharmacokinetics’ and then ‘K and V from two points’. Does this agree with your manual calculation?Answers are available in the final section of the book.63Download free ebooks at bookboon.com