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PharmacokineticsDistribution: Compartments and Volume of DistributionT1T4BloodT2T3Figure 3.4 Basis of the two-compartmental modelThere are two principal factors that can influence the rate at which drugs move in and out of tissues. The first is thepolarity of the drug; non-polar drugs undergo passive diffusion easily and so can enter tissues more rapidly than polarones. The other major factor is blood flow; where tissues have a rich blood supply, drugs can be delivered and removedquickly, whereas significant delay is unavoidable where blood flow is sparse. For many drugs, blood flow is the criticalfactor, and for the rest of this chapter, we will focus solely on that, but it should be remembered that polarity can be anissue and we will refer to this at a later point.It is generally assumed that the rate of drug delivery to and removal from, tissues is governed by blood flow.it’s an interesting worldPlease click the advertGet under the skin of it.Graduate opportunitiesCheltenham | £24,945 + benefitsOne of the UK’s intelligence services, GCHQ’s role is two-fold:to gather and analyse intelligence which helps shape Britain’sresponse to global events, and, to provide technical advice for theprotection of Government communication and information systems.In doing so, our specialists – in IT, internet, engineering, languages,information assurance, mathematics and intelligence – get wellbeneath the surface of global affairs. If you thought the world wasan interesting place, you really ought to explore our world of work.TOPGOVERNMENTEMPLOYERwww.careersinbritishintelligence.co.ukApplicants must be British citizens. GCHQ values diversity and welcomes applicants fromall sections of the community. We want our workforce to reflect the diversity of our work.Download free ebooks at bookboon.com26