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<strong>Pharmacokinetics</strong>Additional material available from the internetC 0= C 1/ e -Kt1-0.218h-1 x 2h= 7.1mg/L / e= 7.1mg/L / e -0.436= 7.1mg/L / 0.647= 11.0 mg/LV = D / C 0= 120mg / 11.0mg/L= 10.9 L3.The answers from the spreadsheet should support those from the manual calculation.Chapter 81.LD of salt = Target x V / S= 15mg/L x 42L / 0.75= 840 mgCss = Rinf / ClRinf = Css x Cl(But allowing for use of a salt …)Rinf of salt = Css x Cl / S= 15mg/L x 5L/h / 0.75= 100mg/h2.V = 3L/Kg x 70Kg= 210 LCl = 1.1mL/min/Kg x 70Kg= 77 mL/minTarget = midrange concentration = (2+8) / 2 = 5microgram/LLD = Target x V= 5microgram/L x 210L= 1050microgram= 1.05mgDownload free ebooks at bookboon.com140
<strong>Pharmacokinetics</strong>Additional material available from the internetCss = Rinf / ClRinf = Css x Cl= 5microgram/L x 77mL/min (Convert clearance to units of L/h)= 5microgram/L x (77 x 60) mL/h= 5microgram/L x (77 x 60 / 1000) L/h= 5microgram/L x 4.62L/h= 23.1 microgram/h3.Css = Rinf / Cl= 100microgram/h / 200 mL/min (Convert clearance to units of L/h)= 100microgram/h / (200 x 60) mL/h= 100microgram/h / (200 x 60 / 1000) L/h= 100microgram/h / 12L/h= 8.3 microgram/L4.The stated concentration is half of Css and so this concentration will be achieved when the infusion has beenunderway for a time equivalent to one half-life of the drug.K = Cl/V= 12L/h / 50L= 0.24 h -1t-half = 0.693 / K= 0.693 / 0.24 h -1= 2.9hConcentration will rise to 4.15microgram/L after 2.9h of infusion.5.Css = Rinf / Cl= 10mg/h / 2L/h= 5mg/LK = Cl / V= 2L/h / 45L= 0.0444 h -1t_half = 0.693 / 0.0444 h -1= 15.6hThe time mentioned in the question (32.2h) is equivalent to two elimination half-lives. Hence concentrationwill have risen to 75% of Css.141Download free ebooks at bookboon.com
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