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PharmacokineticsElimination: Elimination rate constant,...4.2.4 Another definition of the elimination rate constantThe definition of K presented in Section 4.1 is said to be expressed in ‘Mass terms’. K was defined as the ratio betweenthe mass of drug eliminated per unit time and the mass of drug present in the body.Figure 4.5, considers clearance in the context of the complete body along with its volume of distribution. The drug isdistributed throughout a space of 50 litres and clearance is indicated as 5 L/h. Thus, five out of fifty litres (one tenth) ofthe volume is cleared per hour, implying that one tenth of the drug present in the body will be removed per hour. So,K must be 0.1 h -1 . Clearance can therefore be expressed alternatively in ‘Volume terms’ as the ratio between the volumefrom which drug is cleared and the total volume throughout which the drug is distributed.K can be defined either as the proportion of the mass of drug that is eliminated per unit time or as the proportion ofthe volume the drug occupies that is cleared per unit time.Trust and responsibilityPlease click the advertNNE and Pharmaplan have joined forces to createNNE Pharmaplan, the world’s leading engineeringand consultancy company focused entirely on thepharma and biotech industries.Inés Aréizaga Esteva (Spain), 25 years oldEducation: Chemical Engineer– You have to be proactive and open-minded as anewcomer and make it clear to your colleagues whatyou are able to cope. The pharmaceutical field is newto me. But busy as they are, most of my colleaguesfind the time to teach me, and they also trust me.Even though it was a bit hard at first, I can feel overtime that I am beginning to be taken seriously andthat my contribution is appreciated.NNE Pharmaplan is the world’s leading engineering and consultancy companyfocused entirely on the pharma and biotech industries. We employ more than1500 people worldwide and offer global reach and local knowledge along withour all-encompassing list of services.nnepharmaplan.comDownload free ebooks at bookboon.com44