Pros and Cons of Bayesian Pharmacometric Modeling Using BUGS

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Computational tools/methods for Bayesian modelingComputer programs implementing Bayesian MCMCComputer programs implementing Bayesian MCMCMore general-purpose software tools implementing MCMC forBayesian modeling include:WinBUGSSAS MCMC procedureOpenBUGSMicrosoft Infer.NETJAGSAdvantagesFlexible stochastic model structureNo limit on levels of variabilityChoice of many distributionsCan easily combine models with very different stochastic structuresDisadvantagesNo specialized support for pharmacometrics applicationsLess flexible specification of structural model (esp. for BUGSvariants)Less computationally-demanding algorithms not available within thesame platformc○2009 Metrum Institute Bayesian Modeling Using BUGS AAPS 2009 7 / 26
Computational tools/methods for Bayesian modelingBUGS language MCMC programsBUGS language MCMC programsWinBUGS, OpenBUGS and JAGS use the BUGS model specificationlanguage.BUGS = Bayesian analysis Using Gibbs SamplingSame basic syntaxSome differences in available functions and distributionsc○2009 Metrum Institute Bayesian Modeling Using BUGS AAPS 2009 8 / 26
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