Pros and Cons of Bayesian Pharmacometric Modeling Using BUGS

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BUGSModelLibraryDescriptionBUGSModelLibraryhttp://bugsmodellibrary.googlecode.comBUGSModelLibrary is a prototype PKPD model library for use withWinBUGS 1.4.3. The current version includes:Specific linear compartmental models:One compartment model with first order absorptionTwo compartment model with elimination from and first orderabsorption into central compartmentGeneral linear compartmental model described by a matrixexponentialGeneral compartmental model described by a system of first orderODEsOpen-source software developed and distributed free of charge byMetrum Institute.c○2009 Metrum Institute Bayesian Modeling Using BUGS AAPS 2009 13 / 26
BUGSModelLibraryDescriptionBUGSModelLibraryThe models and data format are based onNONMEM/NMTRAN/PREDPP conventions including:Recursive calculation of model predictionsThis permits piecewise constant covariate valuesBolus or constant rate inputs into any compartmentHandles single dose, multiple dose and steady-state dosinghistoriesImplemented NMTRAN data items include:TIME, EVID, CMT, AMT, RATE, ADDL, II, SSc○2009 Metrum Institute Bayesian Modeling Using BUGS AAPS 2009 14 / 26
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Pros and Cons of Bayesian Pharmacometric Modeling Using BUGS

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