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Pros and Cons of Bayesian Pharmacometric Modeling Using BUGS

Pros and Cons of Bayesian Pharmacometric Modeling Using BUGS

Pros and Cons of Bayesian Pharmacometric Modeling Using BUGS

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Computational tools/methods for <strong>Bayesian</strong> modelingMore on Win<strong>BUGS</strong>Available distributions (Win<strong>BUGS</strong> 1.4.*)ContinuousDiscreteUnivariate Multivariate Univariate Multivariatebeta Dirichlet Bernoulli multinomialchi-squared normal binomialdouble exponential Student-t categoricalgamma Wishart negative binomialgeneralized gammapoissonlog-normallogistic More flexibilitynormalWin<strong>BUGS</strong> also has a large set <strong>of</strong> built-inparet<strong>of</strong>unctions.Student-tUsers may program custom functionsuniform<strong>and</strong> distribution via the WBDevWeibullpackage.c○2009 Metrum Institute <strong>Bayesian</strong> <strong>Modeling</strong> <strong>Using</strong> <strong>BUGS</strong> AAPS 2009 12 / 26

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