Pros and Cons of Bayesian Pharmacometric Modeling Using BUGS

Pros and consof BUGSPros and cons of BUGSProsMuch more flexible stochastic structureNo restriction on number of levels of random effectsMany built-in distribution functions plus ability to add moreEasier to combine models for multiple types of data, e.g.:Individual patient data + summary dataPreclinical + clinical dataConsAvailability of pharmacometrics modeling tools, e.g.,BUGSModelLibrary.Lack of less computationally-demanding methods within the sameplatform to support exploratory modeling, e.g., estimation ofposterior modes.Component Pascal programming required for development ofmore complex structural models.c○2009 Metrum Institute Bayesian Modeling Using BUGS AAPS 2009 25 / 26