Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...

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Significant Histological Findingsin Patients with Normal ALT• Study compared liver histology in CHBpts with persistently normal (n=139) andabnormal (n=135) ALT• Normal ALT group:– 24% significantfibrosis–9.4% cirrhosis• Within normal ALT range, fibrosis ratehigher in ptswith higher ALT• Age >40 years significant risk forfibrosis• No correlation with HBeAg status orHBV DNA level50403020100Risk of Fibrosis by ALT Level43.519.8Percent
Should our roadmapinterpret HBV DNA?•Is there any level of HBVDNA which is “safe” forHBV patients?–No risk for HCC or cirrhosis
Page 2 and 3: GPS, Road Map or Seeing EyeDog?
Page 5 and 6: Basics• For any person at risk fo
Page 7 and 8: All patients: consider• Documenti
Page 9: Should the roadmap include“health
Page 13 and 14: One Idea for aRoadmap•DNA +Treat
Page 15 and 16: $$Financial GradientDNA >2,000 IULa
Page 17 and 18: Real World: Insurance and costrestr
Page 19 and 20: HBeAg seroconversion is considered
Page 21 and 22: Should the new Roadmapinclude pretr
Page 23 and 24: Changes in Size of Esophageal Varic
Page 25 and 26: How does the adefovirtreatment vehi
Page 27 and 28: ADV+LAM vs.. ADV for HBeAg- LAM-R P
Page 29 and 30: Results:Projected Ten-Year Risk: Us
Page 31 and 32: TenofovirHBeAg+ patients: % HBV DNA
Page 33 and 34: The Resistance Route if full of can
Page 35 and 36: Resistance is badResistance is comm
Page 37 and 38: Management of HBV ResistanceLamivud
Page 39 and 40: What does the roadmap say is the be
Page 41 and 42: Who is best patient for interferon?
Page 43 and 44: Roadmap to manage or prevent resist
Page 45 and 46: Ultra-Deep Pyrosequencing forHIVWan
Page 47 and 48: What is the best road map tomanage

Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...

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