Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...

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Pre-existing core promoter and pre-coremutants in HBV patients• In patients with HBeAg(+) disease, the presence of core promoter andpre-core mutants is common27-42% of patients with HBeAg + disease have the mutant HBV virusAll patientsHBeAg(+)HBeAg(-)80% 80Core promoter variant%707060605050404030302010 201000 A B C D AlltypesChu CJ, et al. Gastroenterology 2003;125:444–451.Pre-core variantA B C DAlltypes21
Should the new Roadmapinclude pretreatment precoreand core promoter mutationtesting in all patients who areHBV DNA positive?My recommendation is “yes”22
Page 2 and 3: GPS, Road Map or Seeing EyeDog?
Page 5 and 6: Basics• For any person at risk fo
Page 7 and 8: All patients: consider• Documenti
Page 9 and 10: Should the roadmap include“health
Page 11 and 12: Should our roadmapinterpret HBV DNA
Page 13 and 14: One Idea for aRoadmap•DNA +Treat
Page 15 and 16: $$Financial GradientDNA >2,000 IULa
Page 17 and 18: Real World: Insurance and costrestr
Page 19: HBeAg seroconversion is considered
Page 23 and 24: Changes in Size of Esophageal Varic
Page 25 and 26: How does the adefovirtreatment vehi
Page 27 and 28: ADV+LAM vs.. ADV for HBeAg- LAM-R P
Page 29 and 30: Results:Projected Ten-Year Risk: Us
Page 31 and 32: TenofovirHBeAg+ patients: % HBV DNA
Page 33 and 34: The Resistance Route if full of can
Page 35 and 36: Resistance is badResistance is comm
Page 37 and 38: Management of HBV ResistanceLamivud
Page 39 and 40: What does the roadmap say is the be
Page 41 and 42: Who is best patient for interferon?
Page 43 and 44: Roadmap to manage or prevent resist
Page 45 and 46: Ultra-Deep Pyrosequencing forHIVWan
Page 47 and 48: What is the best road map tomanage

Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...

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