Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...
Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...
Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...
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Pre-existing c<strong>or</strong>e promoter and pre-c<strong>or</strong>emutants in HBV patients• In patients with HBeAg(+) disease, the presence of c<strong>or</strong>e promoter andpre-c<strong>or</strong>e mutants is common27-42% of patients with HBeAg + disease have the mutant HBV virusAll patientsHBeAg(+)HBeAg(-)80% 80C<strong>or</strong>e promoter variant%707060605050404030302010 201000 A B C D AlltypesChu CJ, et al. Gastroenterology 2003;125:444–451.Pre-c<strong>or</strong>e variantA B C DAlltypes21