Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...

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What is the new paradigm?What is the best road map?• Treat all patients until HBsAg negative• Will need cost modeling!• Incremental cost-effectiveness ratios (ICER) perquality-adjusted life-year (QALY) key toidentifying the best road ahead
What does the roadmap say is the bestroute through “interferon” country?• Focused role– High ALT– Low to moderate HBV DNA• When patient asks for defined treatment period– A woman wishing to get pregnant in 1-2 years• Where government pays only for one year of therapy– Choose patient with• Higher ALT• Lower DNA• HBeAg negative patients– Use as first line therapy !• Especially If there is an assay for HBsAg: Architect Assay
Page 2 and 3: GPS, Road Map or Seeing EyeDog?
Page 5 and 6: Basics• For any person at risk fo
Page 7 and 8: All patients: consider• Documenti
Page 9 and 10: Should the roadmap include“health
Page 11 and 12: Should our roadmapinterpret HBV DNA
Page 13 and 14: One Idea for aRoadmap•DNA +Treat
Page 15 and 16: $$Financial GradientDNA >2,000 IULa
Page 17 and 18: Real World: Insurance and costrestr
Page 19 and 20: HBeAg seroconversion is considered
Page 21 and 22: Should the new Roadmapinclude pretr
Page 23 and 24: Changes in Size of Esophageal Varic
Page 25 and 26: How does the adefovirtreatment vehi
Page 27 and 28: ADV+LAM vs.. ADV for HBeAg- LAM-R P
Page 29 and 30: Results:Projected Ten-Year Risk: Us
Page 31 and 32: TenofovirHBeAg+ patients: % HBV DNA
Page 33 and 34: The Resistance Route if full of can
Page 35 and 36: Resistance is badResistance is comm
Page 37: Management of HBV ResistanceLamivud
Page 41 and 42: Who is best patient for interferon?
Page 43 and 44: Roadmap to manage or prevent resist
Page 45 and 46: Ultra-Deep Pyrosequencing forHIVWan
Page 47 and 48: What is the best road map tomanage

Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...

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