Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...

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ETV Efficacy vs.. Baseline HBV DNALevelsMedian HBV DNA Levels of nucleoside naïve, HBeAg positive andnegative patients treated with ETVBaseline HBV DNA (copies/mL)Baseline≥10 1110 10n=87n=4010 9n=14910 8n=14210 7n=97n=8010 6n=2710 5n=1310 410 310 2024 36 48 72Treatment <strong>We</strong>ekColonno RJ, 41 st EASL 2006, Vienna, # 490• ETV efficacy independent ofbaseline HBV DNA levels• 348/369 (94%) patients withbaseline HBV DNA levels
Results:Projected Ten-Year Risk: Use MarkovModelingHCC Cirrhosis Any Liver EventETV 2.9% 8% 8.8%ADV 7.5% 15.7% 17.8%Iloeje et al, EASL 2006, Abstract #497
Page 2 and 3: GPS, Road Map or Seeing EyeDog?
Page 5 and 6: Basics• For any person at risk fo
Page 7 and 8: All patients: consider• Documenti
Page 9 and 10: Should the roadmap include“health
Page 11 and 12: Should our roadmapinterpret HBV DNA
Page 13 and 14: One Idea for aRoadmap•DNA +Treat
Page 15 and 16: $$Financial GradientDNA >2,000 IULa
Page 17 and 18: Real World: Insurance and costrestr
Page 19 and 20: HBeAg seroconversion is considered
Page 21 and 22: Should the new Roadmapinclude pretr
Page 23 and 24: Changes in Size of Esophageal Varic
Page 25 and 26: How does the adefovirtreatment vehi
Page 27: ADV+LAM vs.. ADV for HBeAg- LAM-R P
Page 31 and 32: TenofovirHBeAg+ patients: % HBV DNA
Page 33 and 34: The Resistance Route if full of can
Page 35 and 36: Resistance is badResistance is comm
Page 37 and 38: Management of HBV ResistanceLamivud
Page 39 and 40: What does the roadmap say is the be
Page 41 and 42: Who is best patient for interferon?
Page 43 and 44: Roadmap to manage or prevent resist
Page 45 and 46: Ultra-Deep Pyrosequencing forHIVWan
Page 47 and 48: What is the best road map tomanage

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