Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...
Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...
Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...
- No tags were found...
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Genotype-Independent Numbering Scheme f<strong>or</strong> HBV Polymerase/RTTerminalProtein1 183 349(rt1)<strong>Do</strong>mainSpacer POL/RT RNaseH692 (rt 344)845 a.a.I(G)II(F)F__V__LLAQ__ YMDDA B C D ErtL80V/I rtV173L rtM204V/I/SLMVrtL180MADV rtA181T rtN236TETV Resistance rtI169T rtL180M rtT184S/A/I/L/G/C/MrtS202C/G/I rtM204V rtM250I/VTDF Resistance rtL180M rtA181T/V rtA194T/rtM204V/I rtN236TL-dT Resistance rtA181T/V rtM204IClevudine rtL180M rtM204VThe location of the maj<strong>or</strong> antiviral drug-resistant mutations associated with lamivudine (LMV), adefovir (ADV), and entecavir (ETV), telbivudine(LdT) tenofovir (TDF) resistance. Modified from Locarnini S. 2004. Sem in Liver Dis 24 (Suppl 1):3-10.