Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...

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If you are going to use lamivudine, useonly in special settings• Naive: Patient– Low level of virus– Financial restrictions– Active monitoring and management• No alternative therapies• Pregnancy• Combination therapy• Historical and ongoing use and on treatment HBVDNA negative on multiple tests
HBeAg seroconversion is considered apoor therapeutic end pointTreatment-inducedseroconversionn = 116Spontaneousseroconversionn = 182P valueRemission of ALT (months) 14.13 22.44 0.0370Remission of ALT Less robust More robust -HBeAg(-) reactivation rateat 96 months* 44% 25% 0.0460HBeAg reversion at 48 months* 24.09% 11.29% < 0.0094* Adjusted for age, gender and ALT with Cox regressionLim SG, et al. Hepatol Int 2008;2:A217–A218(Abstract PE1049), and poster presentation at APASL 2008.20
Page 2 and 3: GPS, Road Map or Seeing EyeDog?
Page 5 and 6: Basics• For any person at risk fo
Page 7 and 8: All patients: consider• Documenti
Page 9 and 10: Should the roadmap include“health
Page 11 and 12: Should our roadmapinterpret HBV DNA
Page 13 and 14: One Idea for aRoadmap•DNA +Treat
Page 15 and 16: $$Financial GradientDNA >2,000 IULa
Page 17: Real World: Insurance and costrestr
Page 21 and 22: Should the new Roadmapinclude pretr
Page 23 and 24: Changes in Size of Esophageal Varic
Page 25 and 26: How does the adefovirtreatment vehi
Page 27 and 28: ADV+LAM vs.. ADV for HBeAg- LAM-R P
Page 29 and 30: Results:Projected Ten-Year Risk: Us
Page 31 and 32: TenofovirHBeAg+ patients: % HBV DNA
Page 33 and 34: The Resistance Route if full of can
Page 35 and 36: Resistance is badResistance is comm
Page 37 and 38: Management of HBV ResistanceLamivud
Page 39 and 40: What does the roadmap say is the be
Page 41 and 42: Who is best patient for interferon?
Page 43 and 44: Roadmap to manage or prevent resist
Page 45 and 46: Ultra-Deep Pyrosequencing forHIVWan
Page 47 and 48: What is the best road map tomanage

Do We Need A Roadmap or GPS?, Dr. Robert Gish - Hepatitis B ...

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