Diekema.ppt [Compatibility Mode] - Institute of Medicine

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October 2011 ACIP Meeting General Recommendations Working Group Febrile Seizures Subgroup - Assessment • Unclear if risk after simultaneous administration of TIV and PCV13 is greater than with separate administration • Unclear if association between influenza vaccine and febrile seizures is unique to 2010-2011 vaccine strains • Cases with concurrent infection not excluded from analysis • Relatively small numbers of cases • Further investigation is underway to determine if other vaccines besides TIV and PCV13 may be contributing to the febrile seizures • Evaluation of confounding or effect modification by concomitant administration of DTaP with PCV13 or TIV 38
October 2011 ACIP Meeting General Recommendations Working Group Febrile Seizures Subgroup - Conclusions • Benefits of TIV and PCV13 vaccination >> risk • Education of healthcare providers and parents on the increased risk of febrile seizures and benefits of TIV and PCV13 • No change in recommendation for simultaneous administration
Page 1 and 2: Febrile Seizures Associated with Tr
Page 3 and 4: Febrile Seizure Signal Detection En
Page 5 and 6: ACIP General Recommendations Workin
Page 7 and 8: Febrile Seizures Background • Sei
Page 9 and 10: ACIP Recommendations for Influenza
Page 11: Febrile Seizures Signal in the Vacc
Page 14 and 15: Lee, ACIP June 2011
Page 16 and 17: Lee, ACIP FEB 2011 16
Page 20 and 21: Joint Signal Evaluation for TIV and
Page 26 and 27: Updated VSD Analysis, August, 2011
Page 28 and 29: VSD Analysis - Comments • Compare
Page 30 and 31: Burden of Influenza Among Children
Page 33 and 34: Febrile Seizures After Influenza In
Page 35 and 36: 13-valent Pneumococcal Conjugate Va
Page 37: October 2011 ACIP Meeting General R
Page 41 and 42: www.cdc.gov/vaccines/pubs/vis/
Page 43 and 44: Proposed Framework for Determining

Diekema.ppt [Compatibility Mode] - Institute of Medicine

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