Diekema.ppt [Compatibility Mode] - Institute of Medicine

Proposed Framework for Determining When
Vaccine-Associated Febrile Seizures Should Lead
to a Change in ACIP Recommendations
• Benefits of vaccine(s) associated with seizures by age
group (key outcomes prevented)
• Effect of vaccine(s) on preventing febrile seizures
• Association expected to be temporary or ongoing?
• Potential for change in recommendations to result in
missed opportunities to vaccinate or unintended
decreased vaccine uptake with resulting increase in
naturally-occurring infections
• Acceptability to healthcare providers and the public of
potential options under consideration for change in
recommendations
• Programmatic implications and feasibility of making
changes in recommendations